A5045579032- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Contact Mechanics and Variational Inequalities
- Mechanical stress and fatigue analysis
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Dynamics and Control of Mechanical Systems
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Adhesion, Friction, and Surface Interactions
- Renal and Vascular Pathologies
- Effects and risks of endocrine disrupting chemicals
- Atomic and Subatomic Physics Research
- Coronary Interventions and Diagnostics
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Advanced X-ray and CT Imaging
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Transplantation: Methods and Outcomes
- Obesity, Physical Activity, Diet
Skellefteå Hospital
2025
Umeå University
2024
Antaros Medical (Sweden)
2019-2024
Linköping University
2001-2023
Uppsala University
1986-2019
Uppsala University Hospital
2008-2017
AstraZeneca (Sweden)
2006-2015
AstraZeneca (United Kingdom)
2014
Center for Clinical Research Dalarna
2014
Dalarna University
2014
To determine in a multicentre, multivendor trial the diagnostic performance for perfusion-cardiac magnetic resonance (perfusion-CMR) comparison with coronary X-ray angiography (CXA) and single-photon emission computed tomography (SPECT). Of 241 eligible patients from 18 centres, 234 were randomly dosed 0.01, 0.025, 0.05, 0.075, or 0.1 mmol/kg Gd-DTPA-BMA (Omniscan™, GE-Healthcare) per stress (0.42 mg/kg adenosine) rest perfusion study. Coronary artery disease (CAD) was defined as diameter...
Dapagliflozin, a highly selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycaemia and weight in patients with type diabetes mellitus (T2DM) by increasing urinary glucose excretion. Long-term glycaemic control, body composition bone safety were evaluated T2DM after 102 weeks dapagliflozin treatment.This randomized, double-blind, placebo-controlled study (NCT00855166) enrolled [mean: age 60.7 years; HbA1c 7.2%; mass index (BMI) 31.9 kg/m(2) ; 91.5 kg] inadequately...
Excess ectopic fat storage is linked to type 2 diabetes. The importance of dietary composition for in humans unknown. We investigated liver accumulation and body during overfeeding saturated fatty acids (SFAs) or polyunsaturated (PUFAs). LIPOGAIN was a double-blind, parallel-group, randomized trial. Thirty-nine young normal-weight individuals were overfed muffins high SFAs (palm oil) n-6 PUFAs (sunflower 7 weeks. Liver fat, visceral adipose tissue (VAT), abdominal subcutaneous (SAT), total...
Abstract Context Saturated fatty acid (SFA) vs polyunsaturated (PUFA) may promote nonalcoholic liver disease by yet unclear mechanisms. Objective To investigate if overeating SFA- and PUFA-enriched diets lead to differential fat accumulation in overweight obese humans. Design Double-blind randomized trial (LIPOGAIN-2). Overfeeding SFA PUFA for 8 weeks, followed 4 weeks of caloric restriction. Setting General community. Participants Men women who are or have obesity (n = 61). Intervention...
Background. Fibroblast growth factor-23 (FGF23) is a regulator of mineral metabolism and has been suggested to play role in vascular calcification chronic kidney disease (CKD). Data on the association between FGF23 atherosclerosis, both CKD community, limited. Methods. The total body atherosclerosis score (AS) was determined by magnetic resonance imaging-based angiography 306 elderly men women, representing subsample community-based PIVUS cohort. Subjects were divided into three categories...
Impaired insulin sensitivity is linked to cognitive deficits and reduced brain size. However, it not yet known whether involves regional changes in gray matter volume. Against this background, we examined the association between sensitivity, performance, volume 285 cognitively healthy elderly men women aged 75 years from Prospective Investigation of Vasculature Uppsala Seniors (PIVUS) study.Insulin was calculated fasting serum plasma glucose determinations using homeostasis model assessment...
To examine the association between dietary habits, cognitive functioning and brain volumes in older individuals, data from 194 cognitively healthy individuals who participated Prospective Investigation of Vasculature Uppsala Seniors cohort were used. At age 70, participants kept diaries their food intake for 1week. These records used to calculate a Mediterranean diet (MeDi) score (comprising habits traditionally found countries, e.g. high fruits low meat), with higher scores indicating more...
Phthalates, commonly used to soften plastic goods, are known PPAR-agonists affecting lipid metabolism and adipocytes in the experimental setting. We evaluated if circulating concentrations of phthalates were related different indices obesity using data from Prospective Investigation Vasculature Uppsala Seniors (PIVUS) study. Data both dual-energy X-ray absorptiometry (DXA) abdominal magnetic resonance imaging (MRI) used. 1,016 subjects aged 70 years investigated PIVUS Four phthalate...
In brain volumetric studies, intracranial volume (ICV) is often used as an estimate of pre-morbid size well to compensate for inter-subject variations in head size. However, if the estimated ICV biased by example gender or atrophy, it could introduce errors study results. To evaluate how two commonly methods estimation perform, computer assisted reference segmentations were created and evaluated. Segmentations 399 MRI volumes from 75-year-old subjects, with 53 these subjects having...
Abstract. Objective. To test whether leptin and adiponectin are risk markers for a first‐ever stroke. Research design, methods subjects. A nested case‐referent study identified 276 cases with stroke (234 ischaemic 42 haemorrhagic stroke). Prior to the stroke, they had participated in population‐based health surveys northern Sweden (median time between survey was 4.9 years). Referents were matched sex, age, date type of survey, geographical region. Putative including blood pressure (BP),...
In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) would have higher cognitive test scores greater brain volume than those low these fatty acids. Data were obtained from Prospective Investigation Vasculature in Uppsala Seniors (PIVUS) cohort. The EPA DHA was determined by 7-day food protocol 252 cognitively healthy (122 females) at age 70 years. At 75, participants' global function examined, their volumes...
Since bisphenol A (BPA) has been shown to induce obesity in experimental studies, we explored the associations between BPA and fat mass, distribution circulating levels of adiponectin, leptin ghrelin humans.In Prospective Investigation Vasculature Uppsala Seniors (PIVUS), mass were determined 70-year-old men women (n=890) by dual-energy X-ray absorptiometry (DXA) magnetic resonance imaging (MRI) (n=287). Serum analyzed using isotope liquid chromatography/tandem spectrometer...
Chemotherapy of solid tumors is presently largely ineffective at dosage levels that are compatible with survival the patient. Here, it argued a condition raised interstitial fluid pressure (IFP) can be observed in many major factor preventing optimal access systemically administered chemotherapeutic agents. Using prostaglandin E1-methyl ester (PGE1), which known transiently to reduce IFP, was shown 5-fluorouracil (5-FU) caused significant growth inhibition on two experimental rats but only...
In the present paper an algorithm for frictional contact between two elastic bodies is presented. The applied to calculation of evolution pressure when material being removed by fretting. To this end Archard’s law wear implemented into algorithm. It noticed that calculated pressures after a period fretting differ considerably from initial Hertz type pressures. Further, it noted numerical instabilities can occur in explicit calculations, and stability criterion suggested.
We sought to evaluate the effect of particle size and coating material various iron oxide preparations on rate rat liver clearance.The following formulations were used in this study: dextran-coated ferumoxide (size = 97 nm) ferumoxtran-10 21 nm), carboxydextran-coated SHU555A 69 fractionated 12 oxidized-starch coated materials either unformulated NC100150 15 or formulated injection nm). All administered 165 rats at 2 dose levels. Quantitative R2* values obtained during a 63-day time period....
Background Unstable implants in bone become surrounded by an osteolytic zone. This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced fluctuations fluid pressure or flow, caused implant instability.Method To understand the roles of and we describe 3-dimensional distribution lesions response flow a previously reported rat model aseptic 50 rats had piston inserted proximal tibia, designed...
Cardiovascular risk factors have different impact on arterial territories. Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure been shown to be associated an increased of cardiovascular disease, predominantly heart or cerebrovascular diseases. However, data the associations between PTH peripheral atherosclerosis are limited.Two prospective, community-based studies were used. In 306 men women, who 70 years old, from...
Visceral adipose tissue (VAT) and truncal fat predict cardiometabolic disease. Intervention trials suggest that saturated fatty acids (SFA), e.g. palmitic acid, promote abdominal liver storage whereas polyunsaturated (PUFA), linoleic prevent accumulation. Such findings require investigation in population-based studies of older individuals. We aimed to investigate the relationships serum biomarkers PUFA intake as well levels with total content. In a sample 287 elderly subjects PIVUS cohort,...