A5001979794- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Medical and Health Sciences Research
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Angiogenesis and VEGF in Cancer
- Uterine Myomas and Treatments
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Pregnancy-related medical research
- Pregnancy and Medication Impact
- Cell Adhesion Molecules Research
- COVID-19 Impact on Reproduction
- Cancer Risks and Factors
- Complementary and Alternative Medicine Studies
- Urticaria and Related Conditions
- Sperm and Testicular Function
- Lymphatic System and Diseases
- Reproductive tract infections research
- Reproductive Physiology in Livestock
- Ethics and Legal Issues in Pediatric Healthcare
- Reproductive Health and Contraception
Düsseldorf University Hospital
2012-2024
Heinrich Heine University Düsseldorf
2015-2024
Hochschule Düsseldorf University of Applied Sciences
2021
Universitäts Frauenklinik
2018-2020
Klinik für Frauenheilkunde
2013-2018
Olgahospital
2014
Abstract Aim The aim of this official guideline published by the German Society Gynecology and Obstetrics (DGGG) coordinated with Urology (DGU) Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained evaluating relevant literature, on counseling fertility preservation for prepubertal girls boys as well patients reproductive age. Statements recommendations women are presented below. or men not focus guideline. Methods This S2k was developed at suggestion...
The molecular signature of endometrial receptivity still remains barely understood, especially when focused on the possible benefit therapeutical interventions and implantation-related pathologies. Therefore, protein composition tissue isolated primary cells (endometrial stromal cells, ESCs) from scratchings ART (Assisted Reproductive Techniques) patients with repeated implantation failure (RIF) was compared to volunteers proven fertility during time embryo (LH + 7). Furthermore, an analysis...
Abstract Purpose Infertility is a debilitating situation that millions of women around the world suffer from, but causal relationship between infertility and endometriosis still unclear. We hypothesize immune cell populations uterine natural killer cells (uNK) plasma (PC) which define chronic endometritis could differ in patients with or without therefore be link to endometriosis-associated infertility. Methods Our retrospective study includes 173 underwent an endometrial scratching...
Abstract The cryopreservation of ovarian tissue with subsequent transplantation the represents an established method fertility protection for female patients who have to undergo gonadotoxic therapy. procedure can be performed at any point in cycle and thus generally does not lead delay oncological With aid this procedure, more than 130 births date worldwide been able recorded. birth rate is currently approximately 30% it assumed that will increase through further optimisation surgical...
Successful embryonic implantation depends on a synchronized embryo-maternal dialogue. Chemokines, such as chemokine ligand 1 (CXCL1), play essential roles in the maternal reproductive tract leading to morphological changes during decidualization, mediating acceptance towards semi-allograft embryo and induction of angiogenesis. Chemokine binding their classical G-protein coupled receptors is essentially supported by syndecan (Sdc) family heparan sulfate proteoglycans. The aim this study was...
Abstract Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic therapeutic challenge. The first German/Austrian/Swiss interdisciplinary S2k guideline on “Diagnosis Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. This developed the context of guidelines program German Society Gynecology Obstetrics (DGGG) cooperation Swiss (SGGG) Austrian (OEGGG). Aims One third causes involuntary...
Abstract Background As of today, the effect coronavirus disease 2019 (COVID-19) on male fertility remains unclear. Studies published so far have partly contradictory results, likely due to very small sample sizes and heterogeneous populations. To gain a deeper understanding impact COVID-19 fertility, we performed prospective case–control study, in which examined ejaculate 37 subjects, including 25 subjects acute phase mild 12 who did not suffer from COVID-19. Determination semen parameters,...
Abstract Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic therapeutic challenge. The first German-language interdisciplinary S2k guideline on “Diagnosis Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. developed the context of guidelines program German Society Gynecology Obstetrics (DGGG) cooperation Swiss (SGGG) Austrian (OEGGG). Aim In one third cases, cause involuntary...
Endometrial epithelial cells are known to undergo apoptosis during trophoblast invasion. We postulate that the cell surface molecule Syndecan-1 which is expressed on endometrial and syncytiotrophoblast important for implantation in general especially induction of maternal invasion because Syndecan-1's influence apoptotic susceptibility cancer already described literature. Using human line RL95-2, a new stable with knockdown was generated. Via antibody array analysis, significant decrease...
Successful implantation of the embryo into human receptive endometrium is substantial for establishment a healthy pregnancy. This study focusses on role Syndecan-1 at embryo-maternal interface, multitasking coreceptor influencing ligand concentration, release and receptor presentation, cellular morphology. CXC motif 1, being involved in chemotaxis angiogenesis during implantation, special interest as Syndecan-1. Human endometrial stromal cells with without knock-down were decidualized...
Human embryo invasion and implantation into the inner wall of maternal uterus, endometrium, is pivotal process for a successful pregnancy. Whereas disruption endometrial epithelial layer was already correlated with programmed cell death, role apoptosis subjacent stromal cells during indistinct. The aim to clarify whether plays in characterize if apoptotic susceptibility embryonic stimuli influenced by decidualization Syndecan-1. Therefore, immortalized human line St-T1 used first generate...
: In this observational prospective cohort study, conducted at the Fertility Centre of University Hospital, Duesseldorf Germany, spontaneous reversal capacity and effect waiting time on an adverse vaginal microbiome profile in subfertile patients were investigated.
Introduction: Patients receiving fertility treatment in Germany appear to be disadvantaged comparison those other countries due the restrictive Embryo Protection Act ("Embryonenschutzgesetz, ESchG"), which prohibits selection of a "top" embryo. The so-called German Middleway ("Deutscher Mittelweg, DMW") now provides for liberal interpretation ESchG by allowing culture numerous pronuclear stages (2PN stage). Materials and Methods: Retrospective cohort study 2 assisted reproduction cycles n =...
Displaced endometrial receptivity has been discussed as a possible cause of recurrent implantation failure in patients undergoing assisted reproductive technology. The aim this study was to document our experience with the analysis failure.This retrospective cohort study, conducted at Fertility Centre University Hospital, Duesseldorf Germany, presents results 67 and compares clinical outcome between these who underwent personalized frozen-thawed embryo transfer guided by 32 performed...
A successful implantation of a mammalian embryo into the maternal endometrium depends on highly synchronized fetal-maternal dialogue involving chemokines, growth factors, and matrix-modifying enzymes. growing body evidence suggests an important role for proteinases playing in matrix degeneration enhancing embryo's invasive capacity influencing mother's immunological status favor conceptus. This study focused expression cathepsin S (CTSS) its inhibitors murine interface as well detection...
Syndecan-1 is a heparan sulfate proteoglycan acting as co-receptor for cytokines and growth factors mediating developmental, immunological angiogenic processes. In human, the uteroplacental localization of its reduced expression in pregnancy-associated pathologies, such intrauterine restriction, suggests an influence embryo-maternal interactions. The aim present study was to identify effect on reproductive phenotype mice their progenies.Reproductive characteristics have been investigated...