A5057764252- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Blood Coagulation and Thrombosis Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiovascular Issues in Pregnancy
- Ovarian function and disorders
- Ectopic Pregnancy Diagnosis and Management
- Medical and Health Sciences Research
- Sperm and Testicular Function
- Reproductive Health and Technologies
- Estrogen and related hormone effects
- Gynecological conditions and treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Endometriosis Research and Treatment
- Menopause: Health Impacts and Treatments
- Pregnancy and Medication Impact
- Gestational Trophoblastic Disease Studies
- S100 Proteins and Annexins
- Chromosomal and Genetic Variations
- Reproductive Health and Contraception
- Birth, Development, and Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hormonal and reproductive studies
- Animal Genetics and Reproduction
Ludwig-Maximilians-Universität München
2015-2024
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2014-2024
LMU Klinikum
2008-2024
Klinik für Frauenheilkunde
2014-2024
Klinikum rechts der Isar
2016-2022
Weatherford College
2021
Leipzig University
2015
University Hospital Heidelberg
2015
University Hospital Schleswig-Holstein
2015
University of Tübingen
2015
Abstract Purpose Official guideline of the German Society Gynecology and Obstetrics (DGGG), Austrian (ÖGGG) Swiss (SGGG). The aim this was to standardize diagnosis treatment couples with recurrent miscarriage (RM). Recommendations were based on current literature views involved committee members. Methods Based literature, members developed statements recommendations in a formalized process which included DELPHI rounds formal consensus meeting. for patients RM compiled international...
PROBLEM: Thrombophilic predisposition may be one of the underlying causes recurrent spontaneous abortions (RSA). We studied prevalence five thrombophilic gene mutations in patients with RSA. METHOD OF STUDY: 102 two or more consecutive and 128 women without miscarriage were analyzed for factor V Leiden mutation (FVL), prothrombin G20210A (PTM), C677T 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene, glycoprotein IIIa (GPIIIa) C1565T polymorphism, β‐fibrinogen G‐455A polymorphism by...
A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit questionable.To determine whether LMWH increases ongoing and live-birth rates in RPL.Controlled, multicenter trial randomization using minimization conducted from 2006 2013. (ClinicalTrials.gov: NCT00400387).14 university hospitals perinatal care centers Germany Austria.449 at least 2 consecutive early miscarriages or 1...
Could the protamine-1 to protamine-2 mRNA ratio serve as a biomarker estimate fertilizing capacity of sperm from men taking part in an IVF/ICSI programme? The protamine clearly discriminates between fertile and subfertile with normal exhibit higher IVF/ICSI. Aberrant ratios are associated male factor infertility is comparable protein (due transcriptional stop elongating spermatids). study population was drawn men, whose female partners participated IVF or ICSI programmes September 2010...
Are ten-eleven-translocation (TET) 1-3 family enzymes involved in human spermatogenesis and do they impact male fertility?TET1, TET2 TET3 are successively expressed at different stages of spermatogenesis, their expression levels associate with fertility.Spermatogenesis is a complex cell differentiation process accompanied by drastic epigenetic remodeling. TET1-3 dioxygenases essential for active DNA demethylation the paternal pronucleus embryonic stem cells.Expression mRNAs proteinss...
Background: The use of different definitions and diagnostic approaches polycystic ovary syndrome (PCOS) recurrent miscarriage (RM) has led to a wide range prevalence rates in the literature. Despite persistent controversy about factual PCOS RM, vast number studies have revealed evidence their association with each other. goals this study were evaluate ovarian morphology within RM population, performing meta-analyses obtained data from study, together previous reports on topic evaluating...
Are unexplained recurrent miscarriages associated with abnormal protamine-1 and protamine-2 mRNA levels in spermatozoa?Both as well the to ratio spermatozoa from men whose female partners experienced two or more consecutive were significantly different compared those both healthy control subfertile couples undergoing IVF/ICSI.Aberrant sperm protamine ratios are known be male-factor infertility. Data this study suggest that may additionally affect early embryo development.The population was...
Abstract Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic therapeutic challenge. The first German/Austrian/Swiss interdisciplinary S2k guideline on “Diagnosis Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. This developed the context of guidelines program German Society Gynecology Obstetrics (DGGG) cooperation Swiss (SGGG) Austrian (OEGGG). Aims One third causes involuntary...
Problem Recurrent miscarriage (RM) affects 1–3% of couples. So far, diagnostic procedures are performed only in female patients. However, the main part placentary perfusion is encoded by both maternal and paternal genome. Method study In this case–control study, German couples with two ( n = 49) or three more RM 102) 157 control were analyzed for factor V‐Leiden 1691G>A mutation (FVL), prothrombin (PT) 20210G>A substitution, 677C>T replacement 5,10‐methylenetetrahydrofolate...
<b>Purpose:</b> Official guideline coordinated and published by the German Society of Gynecology Obstetrics (DGGG). Aim was to standardize diagnosis treatment patients with recurrent miscarriage (RM). Recommendations were proposed, based on current national international literature experience involved physicians. Consistent definitions, objective assessments standardized therapy applied. <b>Methods:</b> Members different societies developed a consensus in an informal process literature. The...
BackgroundWe recently demonstrated the increased abundance of anti-trophoblast antibodies (ATAB) in sera patients with unexplained recurrent miscarriages (uRM). Further, ATAB-positive bound to JEG-3 human choriocarcinoma cells vitro, resulting decreased productions β-human chorionic gonadotropin (β-hCG) and progesterone these cells. However, specific antigenic epitopes ATAB have remained unknown. Therefore, it was aim this study determine targets uRM patients.MethodsPotential were analyzed...
Abstract Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic therapeutic challenge. The first German-language interdisciplinary S2k guideline on “Diagnosis Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. developed the context of guidelines program German Society Gynecology Obstetrics (DGGG) cooperation Swiss (SGGG) Austrian (OEGGG). Aim In one third cases, cause involuntary...
Background Over the past decades, assisted reproductive technologies (ART) have gained remarkable influence in treatment of infertility and account for more than 2 % births European countries nowadays. Accumulating evidence suggests ART to cause cardiovascular alterations, including left ventricular (LV) dysfunctions, within its offspring. The aim this study was assess LV systolic function subjects conceived through comparison spontaneously peers. Methods For assessment morphology function,...
Problem We report on a successful ovarian stimulation and pregnancy in patient with ‘resistant ovary syndrome’ ( ROS ) antigonadotrophin antibodies. is characterized by high endogenous gonadotrophins, low estradiol, normal antral follicle counts antimuellerian hormone values. Method of Study After cyclical treatment, downregulation Gn RH analogue ICSI procedure followed. Granulosa cells were treated LH , FSH or hMG expression receptors for oestrogen receptor beta ER b) progesterone A PR‐A...
The endothelial glycocalyx (EGX) plays an important role in vascular integrity. Recently, increased levels of EGX components were detected the circulating blood healthy pregnant women and related to tendency edema formation during gestation. However, has not yet been systematically studied non-pregnant ovulatory cycles.Serum syndecan-1, heparan sulfate, hyaluronan (n = 16) at 3 phases cycle (early follicular phase, ovulation, mid-luteal phase) compared with a control group men 10). Using...
Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed evaluate whether subtle differences in LV diastolic can be observed echocardiographically between young ART subjects and their spontaneously peers. The echocardiographic assessment included the measurement of dimensions, mitral inflow velocities, myocardial velocity at early diastole (E', cm/s) wall...
This study presents sample size considerations derived from the Efficacy of Thromboprophylaxis as an Intervention during Gravidity (EThIGII) trial (ClinicalTrials.gov: NCT00400387) to address question low-molecular-weight heparin (LMWH) treatment in women with recurrent pregnancy loss (RPL) depending on M2/ANXA5 haplotype. To evaluate possible influence such miscarriage rates participants, a post hoc analysis ANXA5 promoter genotypes light ( RPRGL3) distribution was performed using logistic...