A5081943499- Childhood Cancer Survivors' Quality of Life
- Breast Cancer Treatment Studies
- Acute Lymphoblastic Leukemia research
- Family Support in Illness
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Palliative Care and End-of-Life Issues
- Breast Implant and Reconstruction
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer survivorship and care
- Nutrition and Health in Aging
- Neuroblastoma Research and Treatments
- Frailty in Older Adults
- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Adolescent and Pediatric Healthcare
- Heart Failure Treatment and Management
- Cancer Risks and Factors
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Clinical practice guidelines implementation
- Cancer Treatment and Pharmacology
- Ovarian cancer diagnosis and treatment
- Advances in Oncology and Radiotherapy
- Reproductive Biology and Fertility
Princess Máxima Center
2017-2025
Stichting Kinderoncologie Nederland
2017-2024
University of Amsterdam
2023
Amsterdam University Medical Centers
2023
Stichting HIV Monitoring
2023
Amsterdam UMC Location University of Amsterdam
2017
University of Groningen
2017
University Medical Center Groningen
2017
The Netherlands Cancer Institute
2016-2017
Emma Kinderziekenhuis
2017
Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term of SMNs in a well-characterized cohort 5-year CCSs, with particular focus on individual chemotherapeutic agents and solid risk. Methods The Dutch Cancer Oncology Group-Long-Term Effects After includes 6,165 CCSs diagnosed between 1963 2001 Netherlands. were identified by linkages Netherlands Registry, Pathology medical chart review. calculated standardized...
Background Heart failure is one of the most important late effects after treatment for cancer in childhood. The goals this study were to evaluate risk heart failure, temporal changes by periods, and factors childhood survivors ( CCS ). Methods Results DCOG‐LATER (Dutch Childhood Oncology Group–Long‐Term Effects After Cancer) cohort includes 6,165 5‐year diagnosed between 1963 2002. Details on prior diagnosis collected nationwide cohort. Cause‐specific cumulative incidences obtained. Cardiac...
Childhood cancer survivors face late health problems; despite advances in research, details on risk remain unclear. We describe the methodological aspects of Dutch Cancer Survivor Study (DCCSS) cross-sectional clinical study (LATER 2 study).From multi-center DCCSS LATER cohort 6165 five-year diagnosed during 1963-2001, we invited 4735 eligible 2016, as well siblings and parents survivors. Gaps evidence identified development surveillance guidelines were translated into research questions for...
Abstract Background Because the occurrence of metabolic syndrome (MetS) might contribute to childhood cancer survivor’s excess risk cardiovascular disease, authors assessed prevalence and determinants MetS in Dutch Childhood Cancer Survivor Study (DCCSS‐LATER2) cohort. Methods In total, 2338 adult survivors (CCS) were cross‐sectionally for MetS, using Lifelines cohort ( N = 132,226 adults without a history cancer) as references. The was clinically existing classifications, well an...
This study was conducted to determine the impact of neoadjuvant chemotherapy (NAC) on likelihood breast-conserving surgery (BCS) performed for patients with invasive lobular breast carcinoma (ILC) and ductal (IDC). Female a diagnosis ILC or IDC in The Netherlands between July 2008 December 2012 were identified through population-based Cancer Registry. A total 466 received NAC compared 3622 patients. Downstaging by seen 49.7 % 69.6 IDC, pathologic complete response (pCR) observed 4.9 20.2...
Childhood cancer survivors at risk for heart failure undergo lifelong echocardiographic surveillance. Previous studies reported the limited diagnostic accuracy of N-terminal pro–B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) in detecting left ventricular (LV) dysfunction. However, potential enhanced through combination biomarkers clinical characteristics has been suggested. The aim this study was to develop internally validate a model that combines...
There is much debate on the necessity of regionalization ovarian cancer care. We investigated association between hospital type and survival patients with in The Netherlands. A retrospective, population-based cohort study was performed all Dutch diagnosed from January 1, 1996, through December 31, 2003. used data Netherlands Cancer Registry that were linked to mortality Statistics database obtain date cause death. Five-year relative ratios, defined as ratio observed patient population...
Which treatment-related factors are (dose-dependently) associated with abnormal hormonal and ultrasound markers of ovarian reserve in female childhood cancer survivors (CCSs)?Cyclophosphamide, procarbazine, a composite group 'other alkylating agents', dactinomycin, doxorubicin, mitoxantrone, spinal radiotherapy (RT), abdominal/pelvic RT total body irradiation were multivariably markers, dose-effect relationships being established for procarbazine RT.Female at an increased risk reduced...
Purpose The aim of this study was to evaluate contemporary rates local recurrence (LR) and regional (RR) in young patients with breast cancer relation tumor biology as expressed by biomarker subtypes. Patients Methods Women < 35 years age who underwent surgery for primary unilateral invasive between 2003 2008 were selected from the Netherlands Cancer Registry. categorized according subtypes on basis hormone receptor (HR) human epidermal growth factor 2 (HER2) status. 5-year risks...
Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma factors with emphasis on independent and joint effects CrRT dose, exposed volume, exposure age, chemotherapy.The Dutch Cancer Oncology Group-Long-Term Effects after Childhood (DCOG-LATER) cohort includes 5-year childhood cancer survivors (CCSs) whose cancers were diagnosed in 1963-2001. Histologically confirmed benign meningiomas identified from the population-based Pathology Registry (PALGA;...
Childhood cancer survivors (CCS) are at risk for cardiotoxicity.We sought to assess how cardiac dysfunction measurements in CCS overlap and differentially influenced by factors.This cross-sectional Dutch Cancer Survivor Study evaluated echocardiograms of 1,397 ≥5-year 277 siblings. Of CCS, n = 1,254 received cardiotoxic (anthracyclines/mitoxantrone/radiotherapy involving the heart region [RTheart]) 143 potentially (cyclophosphamide, ifosfamide, or vincristine) therapy. We assessed...
This study aimed to increase our understanding of the psychosocial well-being young adult childhood cancer survivors (YACCS) as well positive and negative impacts cancer.YACCS (aged 18-30, diagnosed ≤ 18, time since diagnosis ≥ 5 years) cross-sectionally filled out "Pediatric Quality Life Inventory Young Adults" (PedsQL-YA), "Hospital Anxiety Depression Scale" (HADS), "Checklist Individual Strengths" (CIS-20R) measure fatigue survivor-specific "Impact Cancer - Childhood Survivors" (IOC-CS),...
Cancer-related fatigue is a debilitating late effect after treatment for childhood cancer. The prevalence of in cancer survivors (CCSs) and associated factors has varied widely previous studies. Two important aspects cancer-related fatigue, its severity chronicity, are often not assessed. This study investigated the of, risk for, severe chronic (CF) national cohort Dutch CCSs.In this study, 2810 CCSs (5-year all malignancies diagnosed between 1963 2001 with current age 12-65 years) 1040...
Abstract Background Childhood cancer survivors are at risk for developing long‐term adverse health outcomes. To identify the of and factors specific outcomes, well‐established cohorts needed with detailed information on childhood diagnosis, treatment, We describe design, methodology, characteristics, data availability Dutch Cancer Survivor Study LATER cohort (1963–2001) part 1; questionnaire linkage studies. Methods The includes 5‐year survivors, diagnosed in period 1963–2001, before age 18...
Studies about support needs of young adult childhood cancer survivors (YACCS) previously focused mainly on information needs. This study assessed and associated factors (sociodemographic, medical, psychosocial functioning) in Dutch YACCS.YACCS (aged 18-30, diagnosed ≤ 18 years, time since diagnosis ≥ 5 years) cross-sectionally filled out a questionnaire regarding their need for various types (concrete information, personal counseling, peer contact) eight domains (physical consequences...
Abstract Context/Objective Diabetes mellitus (DM), a possible adverse effect of childhood cancer treatment, is strongly associated with cardiovascular disease and early mortality in adult survivors (CCS). Here, we assess the prevalence determinants DM our nationwide CCS cohort. Design/Methods In this cross-sectional study, was assessed 2,338 CCS, using Lifelines cohort (n=132,226 adults no history cancer) as reference. defined through serum glucose measurement (fasting ≥7.0mmol/L or...
Abstract Purpose To explore putative causal relations for chronic fatigue (CF) in childhood cancer survivors (CCS) using structural equation modeling (SEM). Methods Interrelationships between factors that were previously associated with CF and their relation investigated SEM discovery methodology. A bootstrap method was used to ascertain how robust each finding was, presenting the percentage of times discovered edge found 1000 samples as a measure confidence (with > 50% needed be...