A5076853872- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Meningioma and schwannoma management
- Childhood Cancer Survivors' Quality of Life
- Myasthenia Gravis and Thymoma
- Adrenal and Paraganglionic Tumors
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Adrenal Hormones and Disorders
- Neuroendocrine regulation and behavior
- Vitamin K Research Studies
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Head and Neck Surgical Oncology
- Cancer survivorship and care
- Chromatin Remodeling and Cancer
- Child and Animal Learning Development
- Genetic Syndromes and Imprinting
- Hair Growth and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Testicular diseases and treatments
- Diverse Legal and Medical Studies
- Neuroscience of respiration and sleep
- Congenital Ear and Nasal Anomalies
Klinikum Oldenburg
2015-2024
Carl von Ossietzky Universität Oldenburg
2021-2024
Uniwersytecki Szpital Dziecięcy
2021
Srinakharinwirot University
2021
Universitätsklinikum Würzburg
2021
Southern Medical University
2021
Nanfang Hospital
2021
University of Münster
2021
Hypothalamic syndrome (HS) in childhood is a rare condition. Its epidemiology not well known because incidence and prevalence are related to very underlying diseases. In addition, different criteria for the used across studies. Recognizing HS may be difficult, due its rareness variety of symptoms. Having diagnostic signs symptoms hypothalamic dysfunction aid early recognition diagnosis, reporting understanding etiology, predicting course management. We aimed define score presence...
Objective Childhood craniopharyngiomas (CP) are often diagnosed after a long duration of history (DOH). Tumor size, hypothalamic involvement (HI), and obesity associated with reduced overall survival (OS) functional capacity (FC). The effect DOH specific symptoms in on presentation at initial diagnosis long-term prognosis unknown. Design Retrospective analysis patients' records prospective longitudinal follow-up. Methods Histories 411 CP patients recruited HIT Endo, KRANIOPHARYNGEOM 2000...
Quality of life (QoL) is frequently impaired in childhood-onset craniopharyngioma (CP) by hypothalamic syndrome. The debate, whether pretreatment involvement (HI) has apriori prognostic impact or surgical lesions (HL) determine outcome, controversial.Survival and outcome CPs recruited between 2007 2014 KRANIOPHARYNGEOM were analyzed with regard to reference-confirmed presurgical HI HL.Radiological findings, BMI QoL assessed at diagnosis during follow-up. was using Pediatric Life (PEDQOL)...
Abstract Objective Craniopharyngiomas (CP) are rare malformational tumors. Clinical presentation and outcome of pediatric patients with CP specific regard to age at diagnosis is not clear. The aim this cohort study was determine clinical in these diagnosed different ages diagnosis. Design Seven hundred nine were recruited from 1999 2021 HIT-Endo KRANIOPHARYNGEOM 2000/2007/Registry 2019 prospectively observed. Methods Age categorized as infants toddlers (<2 years), early childhood (2-6...
Quality of survival, prognosis and long-term outcome are often severely impaired in childhood-onset craniopharyngioma patients (CP). Identification risk factors for sequelae such as growth hormone (GH) deficiency is important appropriate treatment rehabilitation.In a cross-sectional study, 79 CP recruited HIT-Endo before 2000 were analyzed according to GH substitution: a. never GH-treated (noGH); b. only during childhood (pedGH); c. under GH, initiated at adulthood (adultGH); d. continued...
Abstract In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult pediatric differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 by sequencing DNA methylation profiling. Histologically, the series was dominated meningioma subtypes with aggressive behavior, 70% patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18...
Background Proton beam therapy (PBT) is being increas16ingly used to treat residual craniopharyngioma (CP) after hypothalamus-sparing surgery. Compared photon-based radiation (XRT) with PBT, less irradiation in the penumbra reduces scattered dose critical organs neighboring but outside area of treatment, minimizing risk sequelae. Patients and methods Between 2007 2019, 99 290 (34%) childhood-onset CP patients recruited KRANIOPHARYNGEOM received external (RT) (65% 35% XRT). Outcome was...
Summary Background Patients with childhood‐onset craniopharyngioma (CP) often suffer from tumour or treatment‐related hypothalamic lesions (HL). These may alter production of oxytocin, which plays a major role in the regulation eating behaviour and body composition. Objective In CP different degrees HL, we investigated associations between behaviour/eating attitudes, oxytocin saliva concentrations (OSC). Methods cross‐sectional case‐control study on 34 73 healthy controls, OSC were measured...
Abstract Quality of life (QoL) is a critical component aftercare in survivors childhood-onset craniopharyngioma (CP). Visual impairment adversely affects QoL after CP. This study assessed the frequency visual patients with CP and its association QoL. analyzed vision-related recruited 2000–2019 prospective cohort studies KRANIOPHARYNGEOM 2000/2007. Ophthalmologic examinations were performed at diagnosis, three, 12, 36 months, respectively diagnosis. The (PEDQOL) scores, also evaluated...
Background: Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare. Study Design: Observational study pregnancy rate in CP patients recruited KRANIOPHARYNGEOM 2000/2007 since 2000. Results: A total 451 (223 female) have been recruited, 269 (133 were postpubertal at study. Six 133 (4.5%) with a median age 14.9 years diagnosis had 9 pregnancies, giving birth to 10 newborns. Three achieved complete surgical resections. No patient...
Objectives: The current study aimed to investigate whether childhood-onset craniopharyngioma patients are impaired in social-cognitive skills, and individual differences task performance modulated by the neurohormone oxytocin. Study design: We tested 31 adamantinomatous with without hypothalamic lesions 35 age- gender-matched healthy controls. To test for between-group we experimentally assessed participants' abilities interpret social signs or dispositions understand others' thoughts,...
Background Craniopharyngiomas (CP) are histologically benign (WHO grade 1), embryonal malformations which related to remnants of the Rathke’s pouch and located in (peri)sellar region. Already before CP diagnosis, many patients show a reduced growth velocity tend present with weight gain. However, it is unknown whether develop an increased head circumference (HC) could be useful early diagnostic indicator. Patients methods For cohort 83 recruited multicenter studies KRANIOPHARYNGEOM 2000...
Cerebral infarction (CI) is a known vascular complication following treatment of suprasellar tumors. Risk factors for CI, incidence rate, and long-term prognosis are unknown patients with childhood-onset craniopharyngioma (CP). MRI 244 CP patients, recruited between 2007 2019 in KRANIOPHARYNGEOM 2007, were reviewed CI. CI outcome after analyzed. Twenty-eight (11%) presented based on reference assessment MRI. One occurred before initial surgery one case release intracystic pressure by cyst...
Background Craniopharyngiomas (CPs) are rare embryonic tumors. Clinical presentation and outcome of patients perinatally diagnosed with congenital CP (cCP) not clear refer mainly to a few case reports in the literature. The aim this study was analyze clinical cCP. Study design Three hundred sixty-one adamantinomatous were recruited 2007–2022 KRANIOPHARYNGEOM 2007/Registry 2019 prospectively observed. In two cases, cCP prenatally one on second day life. Pre- perinatal diagnostic findings,...
Abstract Hypothalamic obesity caused by childhood-onset craniopharyngioma results in long-term cardiovascular morbidity. Knowledge about clinical markers and risk factors for morbidity is scarce. A cross-sectional study on transthoracic echocardiographic parameters was performed to determine the associations with anthropometric 36 patients. BMI correlated thickness of interventricular septum diastole (IVSd) ( r = 0.604, p < 0.001) left ventricular posterior wall (LVPWd) 0.460, 0.011). In...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)