A5071230552- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects of Natural Compounds
- Medical Research and Treatments
- Hepatitis B Virus Studies
- MRI in cancer diagnosis
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Mycobacterium research and diagnosis
- Anesthesia and Sedative Agents
- Bacterial Infections and Vaccines
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Microbial Metabolism and Applications
- Advanced MRI Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
- Acute Lymphoblastic Leukemia research
- Bacteriophages and microbial interactions
- T-cell and B-cell Immunology
- Anesthesia and Neurotoxicity Research
- Gestational Trophoblastic Disease Studies
Westmead Institute for Medical Research
2025
Sichuan Agricultural University
2012-2024
Ningbo First Hospital
2024
Ningxia Medical University
2024
Ningxia Medical University General Hospital
2024
Dongguan People’s Hospital
2013-2024
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Nanyang Institute of Technology
2023
Henan University of Science and Technology
2004-2022
Abstract Angiotensin (Ang) A is formed by the decarboxylation of N terminal residue AngII. The present study determined whether this one amino acid change impacted effects AngII on abdominal aortic aneurysm (AAA) formation in mice. Computational analyses implicated that AngA had comparable binding affinity to both type 1 and 2 receptors as To compare these two octapeptides vivo, male low-density lipoprotein receptor (Ldlr) or apolipoprotein E (Apoe) deficient mice were infused with either (1...
The pharmacokinetic analysis of dynamic-contrast-enhanced (DCE) MRI data yields K trans and k ep , two parameters independently measuring the capillary wall contrast reagent transfer rate. almost universally used standard model (SM) embeds implicit assumption that equilibrium transcytolemmal water exchange is effectively infinitely fast. In analyses routine DCE-MRI from 22 patients with suspicious breast lesions initially ruled positive by institutional screening protocols, SM values for...
The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through region-of-interest affects tissue (1)H(2)O relaxation and thus MR image intensity. For longitudinal [R(1) identical with (T(1))(-1)], the CR must have transient molecular interactions water. Because water molecules are never uniformly distributed in histological-scale compartments, kinetics equilibrium compartmental interchange competitive. In particular, condition trans cytolemmal exchange NMR system sorties...
Regulatory T cells (Tregs) help protect against autoimmune renal injury. The use of agonist antibodies and antibody/cytokine combinations to expand Tregs in vivo may have therapeutic potential for disease. Here, we investigated the effects administering IL-2/IL-2Ab complexes mice with adriamycin nephropathy, a model proteinuric kidney disease that resembles human focal segmental glomerulosclerosis. Injecting before or, lesser extent, after induction promoted expansion Tregs. Furthermore,...
Objective— AGT (Angiotensinogen) is the unique precursor of renin-angiotensin system that sequentially cleaved by renin and ACE (angiotensin-converting enzyme) to produce Ang II (angiotensin II). In this study, we determined how these components interact with megalin in kidney promote atherosclerosis. Approach Results— AGT, renin, ACE, were present renal proximal convoluted tubules wild-type mice. Hepatocyte-specific deficiency abolished protein accumulation diminished concentrations kidney,...
Multidrug-resistant bacteria such as Staphylococcus aureus (MRSA) cause infections that are difficult to treat globally, even with current available antibiotics. Therefore, there is an urgent need search for novel antibiotics tackle this problem. Endophytes a potential source of bioactive compounds; however, the harnessing pharmacological compounds from endophytes infinite. study was designed identify endophytic fungi (from Ageratina adenophora) antibacterial activity against...
ABSTRACT Aim CD8 + regulatory T cells (Tregs) are cross‐protective across multiple animal models of autoimmunity. Recently, specific peptides from a yeast‐peptide‐major histocompatibility complex library that expanded Tregs in murine experimental sclerosis were reported. Whether these also expand and protect against Heymann nephritis (HN), an model membranous nephropathy is unknown. We aimed to assess the efficacy peptide vaccination induce HN. Methods Lewis rats immunised with Fx1A/complete...
Objective . The present study was designed to determine whether dexmedetomidine (DEX) exerts cardioprotection against myocardial I/R injury in diabetic hearts and the mechanisms involved. Methods A total of 30 rats induced by high-glucose-fat diet streptozotocin (STZ) were randomly assigned five groups: sham-operated group (DM-S), (DM-I/R), DEX (DM-D), + Wort (DM-DW), (DM-W). Another 12 age-matched male normal SD divided into two (S) (I/R). All subjected min ischemia followed 120 reperfusion...
Eicosanoid and related docosanoid polyunsaturated fatty acids (PUFAs) their oxygenated derivatives have been proposed as noninvasive lipidomic biomarkers of nonalcoholic steatohepatitis (NASH). Therefore, we investigated associations between plasma eicosanoids liver fibrosis to evaluate utility in diagnosing monitoring NASH-related fibrosis.Our analysis used baseline eicosanoid data from 427 patients with biopsy-confirmed disease (NAFLD), longitudinal measurements along staging 63 NASH stage...
The traditional spontaneous solid-state fermentation of Chinese strong-flavor liquor is a complex and unique ecosystem with few abundant many rare taxa. However, the keystone taxa fermented grains (FGs) during are still not completely clear. In this study, we used Illumina MiSeq sequencing to investigate succession fungi fermentation. results showed that changes in alpha beta diversity were significantly different There 9 fungal genera 176 fermentation, dominant changed from Thermoascus...
Endomorphins (EMs) have important roles in the body with regards to analgesia, feeding behavior, gastrointestinal movement and inflammatory reaction. Recent studies reported that EMs may also participate chronic hypoxia protection of rat myocardial ischemia/reperfusion; however, mediator underlying mechanisms remain be elucidated. The aim present study was investigate effects EM‑1 postconditioning on ischemia/reperfusion injury (MIRI) cell apoptosis a model, assess its likely mechanisms. A...
The aim of this study was to investigate the effects Ageratina adenophora on intestines morphology and integrity in rat. Rats were randomly divided into two groups fed with 10 g/100 g body weight (BW) basal diet BW experimental diet, which a mixture A. powder 3:7 ratio. feeding experiment lasted for 60 days. At days 28 experiment, eight rats/group/timepoint selected, weighed, sacrificed, then blood intestinal tissues collected stored further analysis. results showed that caused pathological...
Abstract Studies examining the associations between interleukin‐6 ( IL‐6 ) rs1800795 and rs1800796 gene polymorphisms risk of coronary artery disease (CAD) remain controversial. Our aim was to evaluate accurately determine role these two in CAD risk. PubMed, Embase, VIP, Wan fang China National Knowledge Infrastructure databases were searched. The odds ratios (ORs) 95% confidence intervals (CIs) calculated. trial sequential analysis (TSA) conducted, bioinformatics tools employed. A total...
The increasing number of multi-drug resistant (MDR) bacteria in companion animals poses a threat to both pet treatment and public health. To investigate the characteristics MDR Escherichia coli ( E . ) from dogs, we detected antimicrobial resistance (AMR) 135 isolates diarrheal dogs by disc diffusion method (K-B method), screened antibiotic genes (ARGs), virulence-associated (VAGs), population structure (phylogenetic groups MLST) polymerase chain reaction (PCR) for 74 strains, then further...
Abstract Introduction Bovine viral diarrhoea virus (BVDV) can cause (BVD) in an animal herd, leading to heavy economic losses. There are limited drugs available for treating and controlling BVD. This research aims investigate the antiviral immunoregulatory effects of two traditional Chinese herb extracts against BVDV infection. The matrine icariin, which have been proved immunostimulant effects. Material Methods A cell counting kit-8 assay was used analyse toxicity icariin Madin–Darby bovine...
The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men women with acute aortic dissection (AAD) is needed. We aimed investigate whether sex disparities are found in patients AAD, study complications, mortality in-hospital, long-term.
Objective Obesity has been associated with impaired immunity and increased susceptibility to bacterial infection. It also exerts protective effects against mortality secondary acute lung injury. The of obesity on immune responses injury induced by Escherichia coli were investigated determine if the above‐mentioned differences in its related infection severity. Methods Diet‐induced (DIO) lean control mice received intranasal instillations 10 9 or CFUs E. . examined at 0 h (uninfected), 24 h,...
Delta‑like ligand 4 (Dll4)‑Notch signaling is important in tumor angiogenesis; however, the prognostic value of D114 detection patients with clear cell renal carcinoma (CCRCC) remains unclear. The present study aimed to determine whether presence high Dll4 expression levels was correlated poor prognosis CCRCC following curative resection. four paired samples tissues and adjacent normal were assayed by western blotting. Surgical specimens comprised 121 tissue 65 samples, obtained from CCRCC....
It is widely accepted that maintenance of microbial diversity essential for the health respiratory tract; however, there are limited reports on correlation between starvation and tract diversity. In present study, saline/β-hydroxybutyric acid (BHBA) intravenous injection after dietary restriction was used to imitate different degrees starvation. A total 13 healthy male yaks were imposed restrictions injections, their nasopharyngeal microbiota profiles obtained by metagenomic shotgun...