A5056674081- Axon Guidance and Neuronal Signaling
- HER2/EGFR in Cancer Research
- Renal Diseases and Glomerulopathies
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- T-cell and B-cell Immunology
- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Computational Drug Discovery Methods
- interferon and immune responses
- RNA Interference and Gene Delivery
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Cellular Mechanics and Interactions
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Cell death mechanisms and regulation
- Wound Healing and Treatments
- Cancer-related Molecular Pathways
Sanofi (United States)
2024-2025
AVEO Oncology (United States)
2024
The University of Sydney
2012-2021
Centenary Institute
2019-2021
Merrimack Pharmaceuticals (United States)
2017-2019
Yale University
2006-2017
Children's Hospital at Westmead
2012-2017
University of Alabama at Birmingham
2003-2016
Boston Children's Hospital
2012
London School of Economics and Political Science
2003
Nanopatterning of biomaterials is rapidly emerging as a tool to engineer cell function. Bulk metallic glasses (BMGs), class biocompatible materials, are uniquely suited study nanopattern-cell interactions they allow for versatile fabrication nanopatterns through thermoplastic forming. Work presented here employs nanopatterned BMG substrates explore detection nanopattern feature sizes by various types, including cells that associated with foreign body response, pathology, and tissue repair....
Regulatory T cells (Tregs) help protect against autoimmune renal injury. The use of agonist antibodies and antibody/cytokine combinations to expand Tregs in vivo may have therapeutic potential for disease. Here, we investigated the effects administering IL-2/IL-2Ab complexes mice with adriamycin nephropathy, a model proteinuric kidney disease that resembles human focal segmental glomerulosclerosis. Injecting before or, lesser extent, after induction promoted expansion Tregs. Furthermore,...
Abstract Cell-cell fusion is fundamental to a multitude of biological processes ranging from cell differentiation and embryogenesis cancer metastasis biomaterial-tissue interactions. Fusogenic cells are exposed biochemical biophysical factors, which could potentially alter behavior. While inducers such as cytokines kinases have been identified, little known about the regulation cell-cell fusion. Here, we designed experiments examine using bulk metallic glass (BMG) nanorod arrays with varying...
Autoreactive T cells play a pivotal role in the pathogenesis of autoimmune kidney disease. cell vaccination (TCV) may limit disease and induce CD8+ regulatory (Tregs). We used Heymann nephritis (HN), rat model human membranous nephritis, to study effects TCV on harvested CD4+ from renal tubular antigen (Fx1A) -immunized rats activated these vitro express MHC Class Ib molecule Qa-1. Vaccination Lewis with autoreactive Fx1A-induced protected against HN, whereas control-primed did not. Rats...
Interferons (IFN) are pleiotropic cytokines essential for defense against infection, but the identity and tissue distribution of IFN-responsive cells in vivo poorly defined. In this study, we generate a mouse strain capable reporting IFN-signaling activated by all three types IFNs investigate spatio-temporal dynamics IFN-responding following IFN injection influenza virus infection. Despite ubiquitous expression receptors, cellular responses to highly heterogenous determined anatomical site,...
Abstract CAR T-cells have set a new standard of clinical activity in patients with hematologic malignancies but there are several barriers to broader patient access. Currently, the genetic modification patients' T cells produce CAR-T cell therapies is carried out ex vivo before infusing back into patient, using methods that complex and hinder widespread use. Here we share targeted lipid nanoparticle (LNP) encapsulating mRNA reprogram circulating human vivo, designed overcome significant...
Objective To evaluate the pharmacokinetics and safety of a boosted saquinavir (SQV)/ritonavir (RTV) combination, administered as either hard gelatin capsule (HGC) or soft (SGC) formulation SQV, in 24 healthy volunteers. Methods This was single‐centre, open‐label, randomized, 2 × crossover study. Twelve subjects were randomized to receive SQV/RTV 1000 mg/100 mg twice daily (BID) orally for 10 days, HGC SGC formulation. The pharmacokinetic profile SQV determined on day 10. Subjects then...
AbstractTartrate resistant acid phosphatase (TRAP) activity of bone is a suitable biochemical marker for osteoclastic resorption. Qualitatively, the histochemical distribution TRAP has been used to identify osteoclasts responsible resorption; however, there have few attempts quantify localization. We describe method evaluating resorption by quantifying area percentages positive localization using image analysis. Mouse tibiae were paraffin embedded following demineralization in disodium...
Objective. The brain foreign body response (FBR) is an important process that limits the functionality of electrodes comprise brain-machine interface. Associated events in this include leakage blood–brain barrier (BBB), reactive astrogliosis, recruitment and activation microglia, neuronal degeneration. Proper BBB function also integral to maintaining health function. Previous attempts characterize integrity have shown homogeneous macromolecules up 10 nm size. In study, we describe a new...
Aim: Inflammatory myeloid lineage cells mediate neotissue formation in tissue-engineered vascular grafts, but the molecular mechanism is not completely understood. We examined role of vasculogenic PDGF-B graft development. Materials & methods: Myeloid cell-specific knockout mice (PDGF-KO) were generated using bone marrow transplantation, and scaffolds implanted as inferior vena cava interposition grafts either PDGF-KO or wild-type mice. Results: After 2 weeks, from had more remaining...