A5102975316- Thyroid Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Dietary Effects on Health
- Nutritional Studies and Diet
- Respiratory viral infections research
- RNA regulation and disease
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Cancer Research and Treatments
- Machine Learning in Bioinformatics
- S100 Proteins and Annexins
- Atrial Fibrillation Management and Outcomes
- Immune Response and Inflammation
- Peripheral Neuropathies and Disorders
- Virus-based gene therapy research
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Myocardial Infarction Research
- Artificial Intelligence in Healthcare and Education
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Zhejiang Chinese Medical University
2024
Sun Yat-sen University
2023-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2023-2024
Guangdong University of Technology
2023
Shanghai Sixth People's Hospital
2019-2022
Shanghai Jiao Tong University
2019-2022
Abstract Purpose Lung metastasis (LM) is one of the most frequent distant metastases thyroid cancer (TC). This study aimed to develop a machine learning algorithm model predict lung for providing relative information in clinical decision‐making. Methods Data comprising demographic and clinicopathological characteristics patients with were extracted from National Institutes Health (NIH)’s Surveillance, Epidemiology, End Results (SEER) database between 2010 2015, which employed six models...
Background. The BRAF V600E mutation is an important genetic event in papillary thyroid cancer (PTC). This study aimed to provide additional information regarding the association of with PTC prognosis. Methods. A retrospective single-center based on a Chinese population was performed analyze several clinicopathological features. Kaplan–Meier survival curves and Cox proportional hazards regression analysis were applied implement analysis. Results. present 1102 (87.7%) 1257 patients...
Background New-onset atrial fibrillation (NOAF) is prognostic in acute myocardial infarction (AMI). The timely identification of high-risk patients essential for clinicians to improve patient prognosis. Methods A total 333 AMI were collected who underwent percutaneous coronary intervention (PCI) at Zhejiang Provincial People's Hospital between October 2019 and 2020. Least absolute shrinkage selection operator regression (Lasso) multivariate logistic analysis applied pick out independent risk...
Parkinson's disease (PD) characterized by inflammation and protein erroneous deposition, whose pathological mechanisms have not been elucidated. NcRNA plays important role in PD, especially when circRNA sponges miRNA, which leads to the breakdown of downstream regulation. The aim this study is investigate dynamic changes between upregulated downregulated miRNA during pathogenesis PD their impact on targets. We conducted bioinformatics sequencing data substantia nigra (SN) striatum,...
Abstract Objective The aim of this study was to evaluate the efficacy and safety modified fasting therapy, a retrospective conducted analyze changes in clinical indicators hospitalized patients. Methods A total 2054 patients were enrolled observational study. All participants underwent 7 days therapy. biomarkers, indicators, body composition measured before after fasting. Results therapy reduced weight, BMI, abdominal circumference, systolic blood pressure, diastolic pressure significantly....
<title>Abstract</title> <bold>Objective</bold>: This study aimed to develop a matrix prediction model based on weight loss and improvement in CVD risk factors evaluate the cardiovascular benefits of modifiedfasting therapyin overweight/obese patients with hyperglycemia.<bold>Methods</bold>: CVD-related clinical predictors were extracted from group 3449 hospitalizedindividuals after therapy using logistic regression. Matrix models formulated, corresponding scoring system was developed...
Objective: Papillary thyroid carcinoma (PTC) accounts for 80% of malignancy, and the occurrence PTC is increasing rapidly. The present study was conducted with purpose identifying novel important gene panels developing an early diagnostic model by combining artificial neural network (ANN) random forest (RF). Methods results: Samples were searched from Gene Expression Omnibus (GEO) database, expression datasets (GSE27155, GSE60542, GSE33630) collected processed. GSE27155 GSE60542 merged into...
To investigate the inhibitory effect of hepatitis B virus (HBV) preS2 mini-antibody (mPreS2) against HBV infection, HBV-associated liver injury and hepatic carcinogenesis.A recombinant adenovirus vector with human survivin promoter mPreS2 gene, Ad5SVP-mPreS2, was constructed. Fluorescence microscopy examination TCID 50 analysis were utilized to determine specific proliferation in cancer cells. Western blot used expression levels. Enzyme-linked immunosorbent assay (ELISA) examine HBsAg levels...
Objectives: To investigate factors that may influence humoral immunity post-vaccination with a COVID-19-inactivated vaccine (SC2IV). Methods: 1217 and 379 healthy individuals two-dose SC2IV vaccination from the seventh affiliated hospital, Sun Yat-sen University Shenzhen Baotian Hospital were enrolled, respectively. Physical examination indices recorded. The levels of neutralizing antibody (NA), Spike IgG, receptor-binding domain (RBD) RBD IgG+IgM+IgA, nucleocapsid IgG SARS-CoV-2 measured by...
Abstract Background: Lymph node metastasis is the most common associated with papillary thyroid carcinoma (PTC). There are few data on gene mutations lymph from PTC. At present, mechanism underlying of PTC still poorly understood.Methods: Whole exome sequencing (WES) was performed for 10 primary tumor tissues and (non-match) mutations. Gene ontology (GO) analysis used to study biological functions processes related metastasis. Sanger verify these genes in group.Results: A total 2772 were...