A5100697704- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Amino Acid Enzymes and Metabolism
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Surgical Sutures and Adhesives
- Respiratory viral infections research
- Oral and gingival health research
- Tissue Engineering and Regenerative Medicine
- Natural Antidiabetic Agents Studies
- Pancreatic and Hepatic Oncology Research
- Surgical site infection prevention
- COVID-19 Clinical Research Studies
- Tendon Structure and Treatment
- Polyamine Metabolism and Applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Tryptophan and brain disorders
- Neuroendocrine Tumor Research Advances
- Dermatologic Treatments and Research
- Peripheral Neuropathies and Disorders
- Immune Response and Inflammation
- Curcumin's Biomedical Applications
Longgang Central Hospital
2017-2024
Guangdong Medical College
2020-2022
York District Hospital
2020
University of Hong Kong
2020
International Network for Cancer Treatment and Research
2020
People’s University
2020
Sun Yat-sen University
2007
The First Affiliated Hospital, Sun Yat-sen University
2007
Treatment of soft tissue wounds with bone or tendon exposure remains a tough clinical challenge for surgeons. The current approaches include various types flap reconstruction and artificial dermis grafting as well negative pressure wound therapy (NPWT), which are time-consuming often result in graft failure significant scarring. Concentrated growth factor (CGF) is novel blood extract that contains many factors, platelets fibrin to promote an orderly healing process. However, few reports have...
Bladder cancer is one of the most commonly diagnosed cancers worldwide, especially in males. Current therapeutic interventions, including surgery, radiation therapy, chemotherapy, and immunotherapy, have not been able to improve clinical outcome bladder patients with satisfaction. Recombinant human arginase (rhArg, BCT-100) a novel agent great anticancer effects on arginine-auxotrophic tumors. However, BCT-100 remain unclear. In this study,
Neuroinflammation is associated with the pathophysiology of depression. The molecular mechanism depressive-like behavior caused by sepsis-associated encephalopathy (SAE) incompletely understood. J147 (an analog curcumin) has been reported to improve memory and neuroprotective activity, but its biological function in observed SAE not known. We investigated effects on lipopolysaccharide (LPS)-induced neuroinflammatory, behaviors, toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signal...
Therapeutic effect of autologous concentrated growth factor on lower-extremity chronic refractory wounds: A case report
Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SAE). Microglia-mediated inflammatory signaling is involved anxiety, depression, during acute infection bacterial lipopolysaccharide (LPS). However, the molecular mechanisms underlying microglia activation behavioral deficits sepsis have not been fully elucidated. Based on previous research, we speculated that CD137 receptor/ligand system modulates function to mediate...
Objective: The aim of this study was to explore the effect concentrated growth factor (CGF) on wound healing potential human epidermal cells (HaCaT) in vitro and vivo. Methods: CGF extracted from venous blood using centrifugal separation method. CGF-conditioned medium prepared gel immersed Dulbecco’s Modified Eagle medium. Crystal violet staining assay were used evaluate proliferation migration HaCaT cells, respectively. Lipopolysaccharide (LPS) test anti-inflammatory function CGF. An ELISA...
Management of large jaw cyst is challenging since high risks including pathologic fracture, limited opening, and insufficient bone healing occur after enucleation. The current case concentrated growth factor (CGF) gel to fill defect enucleation rare. A 12-year-old boy with pain swelling for 4 months in the left mandible region made a medical consultation at our hospital. Computerized tomography scan indicated that cystic lesion was found region. In this case, we present patient (31 mm × 44...
Abstract Background Bladder cancer is one of the dominant cancers worldwide, especially for male. Currently, therapeutical regimen bladder based on surgery, radiation therapy, chemotherapy and immunotherapy, but clinical outcome still needed to improve. Recombinant human arginase (rhArg, BCT-100) a novel agent show great anticancer effect arginine auxotrophic tumor. However, rhArg remains unclear. Methods A panel six cell lines (BIU-87, EJ-1, J82, SCaBER, T24 5637) was employed assess...
Objectives: To investigate factors that may influence humoral immunity post-vaccination with a COVID-19-inactivated vaccine (SC2IV). Methods: 1217 and 379 healthy individuals two-dose SC2IV vaccination from the seventh affiliated hospital, Sun Yat-sen University Shenzhen Baotian Hospital were enrolled, respectively. Physical examination indices recorded. The levels of neutralizing antibody (NA), Spike IgG, receptor-binding domain (RBD) RBD IgG+IgM+IgA, nucleocapsid IgG SARS-CoV-2 measured by...
Objective To determine the significance of thymidine phosphorylase for prognosis HCC.Methods The clinical data and pathological finding 65 patients with HCC treated in our hospital were retrospectively analyzed.Immunohistochemical staining was performed to evaluate expression TP MVD count.Statistical analysis used analyze relationship between other parameters.Survival curves 54 plotted using Kaplan-Meier method.Results positive expressed rate tissues significantly higher than that normal...
Objective To study on the changes of epidermal stem cells proliferation in treatment elderly diabetic ulcer wound by negative-pressure therapy (NPWT). Methods Elderly patients with diabetes mellitus complicated chronic refractory wounds were selected from First Affiliated Hospital, Sun Yat-sen University and Shenzhen Longhua District Central Hospital January 2011 to December 2015. NPWT was used treat these wounds. Immunohistochemical method detect integrin beta 1 basal healing...