A5004364449- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Chronic Kidney Disease and Diabetes
- Telomeres, Telomerase, and Senescence
- Cardiac electrophysiology and arrhythmias
- Apelin-related biomedical research
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Nuclear Receptors and Signaling
- Renin-Angiotensin System Studies
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Risk Factors
- Hydrogen's biological and therapeutic effects
- Biomarkers in Disease Mechanisms
- Mitochondrial Function and Pathology
- Perfectionism, Procrastination, Anxiety Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Inflammatory mediators and NSAID effects
North China University of Science and Technology
2021-2025
Humboldt-Universität zu Berlin
2021-2024
Charité - Universitätsmedizin Berlin
2021-2024
Freie Universität Berlin
2021-2024
Klinikum Brandenburg
2021-2024
Community Health Center
2024
Max Delbrück Center
2023
Medizinische Hochschule Brandenburg Theodor Fontane
2023
This study aimed to explore the relationship between trajectory of triglyceride-glucose (TyG) index and occurrence major adverse cardiovascular cerebrovascular events (MACCE) in patients with atrial fibrillation (AF).This prospective included 1979 AF, who were initially selected from Kailuan study. Patients AF split into four groups according value TyG index. The clinical endpoint was MACCE, including myocardial infarction ischemic stroke. Cox proportional hazard models employed examine...
Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammatory and extra-articular involvement. Patients with RA are at increased risk of developing cardiovascular diseases. This retrospective cohort study aimed to determine whether acetylsalicylic acid (aspirin [ASA]) protects against major ischemic vascular events in patients diagnosed RA. Methods were recruited from population 118, 500 participants who enrolled into the Kailuan Cohort Study...
To investigate the effect of atrial fibrillation (AF) on risk for new-onset chronic kidney disease (CKD) and all-cause mortality in a sample Chinese population. A total 1,432 patients with AF were propensity matched (1 : 4) 5,722 individuals without (non-AF group). Clinical endpoints included CKD or mortality. The cumulative incidence two groups was compared using Kaplan-Meier curve analysis. association between assessed Cox proportional hazards model. During 5.9-year follow-up, 190 641...
Few studies have been conducted to investigate the association between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and major adverse cardiac cerebrovascular events (MACCEs) in a predominantly male cohort from China. A prospective study was on total 95,837 individuals (males account for 79.67) extracted Kailuan study. All were grouped according TG/HDL-C quartile. The endpoints of this composite MACCEs its subtypes [non-fatal myocardial (MI), non-fatal stroke all-cause...
Background: Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease that characterized by persistent joint inflammation. RA patients experience considerably increased risk of cardiovascular-related morbidity mortality. The current study investigated the association between triglyceride glucose (TyG) index major adverse cardiovascular events (MACEs) in predominantly male cohort patients. Methods: A total 1613 (81.53% male) were selected from Kailuan study. TyG was calculated as...
Background and aims In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates cardiovascular diseases underserved medical care, there a lack awareness regarding lipoprotein(a) [Lp(a)] as risk factor. addition, data from patients with atherosclerotic disease (ASCVD) in diverse regional backgrounds, including understudied cohort, various healthcare statuses remain insufficient. Methods this WalkByLab study, Lp(a) levels were monitored cohort ( n = 850)...
Abstract Background The association between the triglyceride glucose (TyG) index and risk of early-onset atherosclerotic cardiovascular disease (ASCVD) events or all-cause mortality in young middle-aged people is not fully elucidated. Methods present study included 64,489 who participated 2006 Kailuan Study physical examination. Multivariate Cox proportional hazards models restricted cubic spline curves were used to assess TyG with ASCVD mortality. Results During a median 11-year follow-up,...
Background: Angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are widely used as a first-line therapy for the treatment of cardiovascular disease. Here, ACEI modulate bradykinin (BDKRB1 BDKRB2) system NO-dependent endothelial function, thus determining health regenerative arteriogenesis. The current study aims at evaluating nitric oxide-dependent gene expression receptors in peripheral blood mononuclear cells (PBMC) from patients with or ARB...
We investigated the association between leukocyte telomere length, mitochondrial DNA copy number, and endothelial function in patients with aging-related cardiovascular disease (CVD). In total 430 CVD healthy persons were enrolled current study. Peripheral blood was drawn by routine venipuncture procedure. Plasma peripheral mononuclear cells (PBMCs) collected. Cell-free genomic (cfDNA) leukocytic (leuDNA) extracted from plasma PBMCs, respectively. Relative length (TL) number (mtDNA-CN)...
Atrial fibrillation (AF) and myocardial infarction (MI) share common cardiovascular risk factors, therefore coexistence of AF MI is very common, in addition, both aggravate exacerbate each other through multiple pathological processes. The aim this study to investigate whether increases the new-onset MI.In total 171,086 participants from an industrial city North China were selected enrolled prospective cohort study, divided into group or non-AF according their medical history. 1542...
Arteriogenesis constitutes the most efficient endogenous rescue mechanism in cases of cerebral ischaemia. The aim this work was to investigate whether angiotensin-converting enzyme inhibitors (ACEi) stimulates, and angiotensin II receptor type 1 blockers (ARB) inhibits collateral growth by applying a three-vessel occlusion (3-VO) model rat.Cerebral measured post 3-VO (1) assessing blood flow using cerebrovascular reserve capacity (CVRC) technique, (2) vessel diameters posterior artery (PCA)...
Abstract Background The role of autophagy and autophagy-related genes in peripheral arterial disease (PAD) remains unknown may be diagnostic prognostic value. aim this study is to investigate the relationship between PAD, identify potential or biomarkers for medical practice. Methods Differentially expressed PAD were explored from GSE57691 validated our WalkByLab registry participants by quantitative real-time polymerase chain reaction (qRT-PCR). level blood mononuclear cells (PBMCs) was...
<title>Abstract</title> <bold>Background and purpose</bold>The triglyceride-glucose (TyG) index serves as a convenient surrogate marker for insulin resistance in patients with type 2 diabetes mellitus (T2DM). It is unknown whether TyG may potentially predict CKD the general population. Therefore, current study, we aimed to characterize role of prediction new-onset large community-based prospective cohort study.<bold>Methods/patients</bold>The study encompassed total 85,569 individuals from...
Background: Aspirin (ASA), the mainstay antiplatelet treatment in patients with cardiovascular disease (CVD), has been received by a considerable number of AF patients. This study sought to examine association between ASA monotherapy and risk major adverse cardiac cerebrovascular events (MACCE) atrial fibrillation (AF). Methods: A total 850 were identified from community-based Kailuan study. All assigned two groups according their medicine history: an aspirin therapy group (ASA group) (n =...
The current study aims to investigate the association between endothelial function and lower extremity perfusion in patients with peripheral artery disease (PAD).
Summary: Background: A potential independent association between arterial stiffness (AS) and the development of new-onset chronic kidney disease (CKD) has not been thoroughly examined. Patients methods: total 6929 participants were collected from Kailuan study. All free CKD at baseline. The divided into four groups based on their brachial-ankle pulse wave velocity (baPWV) values. Cox regression models used to analyze relationship baPWV values risk CKD. Results: Over course a 10.06-year...
Purpose: The present study assessed the correlation between anxiety and depression in young middle-aged Chinese patients with coronary artery disease (CAD). Patients Methods: This included 313 diagnosed premature CAD at Department of Cardiology January July 2023. Zung Self-Rating Anxiety/Depression Scale (SAS/SDS) was used as a standardized scale to assess mental health symptoms. A binary logistic regression model (backward) analyze CAD. Results: Anxiety observed 154 persons prevalence...
Abstract This retrospective study explored the association between circulating cell-free plasma telomere length (cf-TL) and coronary artery disease (CAD) heart failure (HF). Data from 518 participants were collected, including clinical laboratory data. cf-TL was measured in samples machine learning (ML) classification models developed to differentiate CAD, HF control conditions. Our results showed that significantly prolonged patients compared controls, but no significant difference observed...
We investigated the pleiotropic effects of an angiotensin receptor-neprilysin inhibitor (ARNi) on collateral-dependent myocardial perfusion in a rat model coronary arteriogenesis, and performed comprehensive analyses to uncover underlying molecular mechanisms.A arteriogenesis was established by implanting inflatable occluder left anterior descending artery followed 7-day repetitive occlusion procedure (ROP). Coronary collateral measured using particle infusion technique. The putative...