A5003130745- Angiogenesis and VEGF in Cancer
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Neurological Disease Mechanisms and Treatments
- Pain Management and Treatment
- Cardiac Imaging and Diagnostics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Telomeres, Telomerase, and Senescence
- Acute Myocardial Infarction Research
- Cardiovascular Health and Risk Factors
- Coronary Interventions and Diagnostics
- Medical and Biological Ozone Research
- Intracranial Aneurysms: Treatment and Complications
- Apelin-related biomedical research
- Blood Coagulation and Thrombosis Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Cardiovascular Issues in Pregnancy
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
Klinikum Brandenburg
2016-2025
Brandenburg University of Technology Cottbus-Senftenberg
2020-2025
University of Potsdam
2020-2025
Medizinische Hochschule Brandenburg Theodor Fontane
2018-2025
Charité - Universitätsmedizin Berlin
2007-2018
Max Delbrück Center
2010-2011
Max Planck Institute for Heart and Lung Research
2011
Deutsches Herzzentrum der Charité
2011
Cardiovascular Research Center
2008
In the developing chicken embryo yolk sac vasculature, expression of arterial identity genes requires hemodynamic conditions. We hypothesize that flow must provide a unique signal is relevant for supporting gene and absent in veins. analyzed factors related to flow, pressure oxygenation vitelline vasculature vivo. The best discrimination between arteries veins was obtained by calculating maximal pulsatile increase shear rate relative time-averaged same vessel: pulse slope index (RPSI). RPSI...
Participants with CAD (n = 723) had 12% higher mean relative levels of nHDLox compared those invasively excluded 502, P < 0.001). Patients presenting symptoms an ACS the highest values when elective cohort (median 1.35, IQR 0.97 to 1.85, In multivariate analysis adjusted for age, sex, body mass index, and hypertension, was a strong independent predictor (P 0.001) but not > 0.05). HDL antioxidant function is reduced in patients CAD. strongly associated ACS. German Clinical Trials Register...
Positive outward remodeling of pre-existing collateral arteries into functional conductance arteries, arteriogenesis, is a major endogenous rescue mechanism to prevent cardiovascular ischemia. Collateral arterial growth accompanied by expression kinin precursor. However, the role signaling via receptors (B1R and B2R) in arteriogenesis unclear.The purpose this study was elucidate bradykinin receptor arteriogenesis.Bradykinin positively affected with contribution B1R being more pronounced than...
Physical activity is a potent way to impede vascular ageing. However, patients who suffer from peripheral artery disease (PAD) are often unable exercise adequately. For those patients, we have developed individual shear rate therapy (ISRT), which an adaptation of external counterpulsation and enhances endovascular fluid stress increase collateral growth (arteriogenesis). To evaluate the effects physical ISRT on telomere biology blood mononuclear cells (PBMCs), conducted two clinical...
Abstract Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by protease calpain, resulting in a truncated fragment strong inductor of myocardial hypertrophy. We now address question whether inhibition calpain function cardiomyocytes, and thereby prevention truncation, attenuates development Methods results generated transgenic mouse model with conditional cardiac calpastatin overexpression (CAST OE) compared their hypertrophic...
Background and aims In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates cardiovascular diseases underserved medical care, there a lack awareness regarding lipoprotein(a) [Lp(a)] as risk factor. addition, data from patients with atherosclerotic disease (ASCVD) in diverse regional backgrounds, including understudied cohort, various healthcare statuses remain insufficient. Methods this WalkByLab study, Lp(a) levels were monitored cohort ( n = 850)...
<i>Background and Purpose:</i> Restoration of cerebrovascular reserve capacity (CVRC) depends on the recruitment positive outward remodeling preexistent collaterals (arteriogenesis). With this study, we provide functional evidence that granulocyte colony-stimulating factor (G-CSF) augments therapeutic arteriogenesis in two animal models cerebral hypoperfusion. We identified an effective dosing regimen improved CVRC stimulated collateral growth, thereby improving outcome after...
Background: Angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are widely used as a first-line therapy for the treatment of cardiovascular disease. Here, ACEI modulate bradykinin (BDKRB1 BDKRB2) system NO-dependent endothelial function, thus determining health regenerative arteriogenesis. The current study aims at evaluating nitric oxide-dependent gene expression receptors in peripheral blood mononuclear cells (PBMC) from patients with or ARB...
We aimed to investigate the tolerability, safety, and effectiveness of enhanced external counterpulsation therapy (EECP) versus individual shear rate (ISRT) in patients with lower extremity atherosclerotic disease (LEAD).Eighteen (age: 73.1 ± 6 years) underwent EECP ISRT, each daily over five consecutive days a cross-over design 1 week resting period between two regimens. A quality-of-life questionnaire was used assess experience. Oxygen saturation (SO2 ), relative hemoglobin amount (rHb)...
Cerebral arteriogenesis constitutes a promising therapeutic concept for cerebrovascular ischaemia; however, transcriptional profiles important target identification have not yet been investigated. This study aims at comprehensive characterization of and morphologic activation during early-phase collateral vessel growth in rat model adaptive cerebral arteriogenesis. Arteriogenesis was induced using three-vessel occlusion (3-VO) nonischaemic hypoperfusion. Collateral tissue from growing...
Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis, with diabetes being one its most significant risk factors. Owing to medial calcification (MAC), the ankle–brachial index (ABI) not always a reliable tool for detecting PAD. Arterial Doppler flow parameters, such as systolic maximal acceleration (ACCmax) and relative pulse slope (RPSI), may serve effective surrogates detect stenosis-induced alteration. In present study, ACCmax RPSI were prospectively...
Abstract. Background: External counterpulsation therapy enhances blood flow and was shown to improve endothelial function quality of life in coronary artery disease patients. However, high pressures up 300 mmHg may lead malperfusion the ischaemic limb. To clinical outcome patients with peripheral (PAD), we adjusted external developed a novel non-invasive approach termed individual shear rate (ISRT). Patients methods: In present study, 14 Fontaine stage IIb femoral-popliteal PAD underwent 30...
We investigated the association between leukocyte telomere length, mitochondrial DNA copy number, and endothelial function in patients with aging-related cardiovascular disease (CVD). In total 430 CVD healthy persons were enrolled current study. Peripheral blood was drawn by routine venipuncture procedure. Plasma peripheral mononuclear cells (PBMCs) collected. Cell-free genomic (cfDNA) leukocytic (leuDNA) extracted from plasma PBMCs, respectively. Relative length (TL) number (mtDNA-CN)...
This study investigated the effects of acetylsalicylic acid (ASA) and clopidogrel, standardly used in secondary prevention vascular occlusions, on cerebral arteriogenesis vivo vitro. Cerebral hypoperfusion was induced by three-vessel occlusion (3-VO) rats, which subsequently received vehicle, ASA (6.34 mg/kg), or clopidogrel (10 mg/kg). Granulocyte colony-stimulating factor (G-CSF), enhanced monocyte migration an additional cell culture model, augmented cerebrovascular subgroups (40 μg/kg)....
Background In the presence of a coronary occlusion, pre-existing small collateral vessels (arterioles) develop into much larger arteries (biological bypasses) that have potential to allow certain level perfusion distal blockage. Termed arteriogenesis, this phenomenon proceeds via complex combination events, with nitric oxide (NO) playing an essential role. The aim study was investigate effects supplemental administration NO donors, i.e., short-acting nitroglycerin (NTG) or slow-release...
Abstract Aims PPAR γ stimulation improves cardiovascular ( CV ) risk factors, but without improving overall clinical outcomes. agonists interfere with endothelial cell EC ), monocyte and smooth muscle SMC activation, function proliferation, physiological processes critical for arterial collateral growth (arteriogenesis). We therefore assessed the effect of on cerebral adaptive therapeutic growth. Methods In a rat model arteriogenesis (3‐ VO were (i) in controls, (ii) after (pioglitazone 2.8...
External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid disease benefit from needs to be validated.Twenty-eight (71 ± 6.5 years, five women) asymptomatic unilateral chronic severe internal stenosis (>70%) or occlusion were randomized receive 20 min active followed by sham treatment vice versa. Cerebral blood flow (CBFV) (measured bilaterally transcranial...
In the United States in 2019, every 40 seconds someone suffers a myocardial infarction and 37 dies of cardiovascular disease (CVD).1 The annual total cost CVD was estimated to be $351.2 billion.1 There are many risk factors that can explain high CV mortality an era modern therapeutic approaches, but significant proportion this might ascribed sedentary lifestyle.2 It has been lifestyle nowadays kills more people worldwide than smoking because remarkably prevalence physical inactivity, which...
Collateral growth, arteriogenesis, represents a proliferative mechanism involving endothelial cells, smooth muscle and monocytes/macrophages. Here we investigated the role of Density-Enhanced Phosphatase-1 (DEP-1) in arteriogenesis vivo , protein-tyrosine-phosphatase that has controversially been discussed with regard to vascular cell biology. Wild-type C57BL/6 mice subjected permanent left common carotid artery occlusion (CCAO) developed significant diameter increase distinct arteries...
Individual shear rate therapy (ISRT) has been designed as a novel non-invasive treatment option for peripheral artery disease (PAD) patients and shown to improve endothelial function walking distance. The aim of this study was elucidate the impact ISRT on level nitric oxide in patient blood plasma expression related molecular markers mononuclear cells (PBMCs). Molecular diagnostic tests were performed two trials.In ISRT-1 26 healthy subjects underwent one session treadmill training...