A5101765890- Plant Molecular Biology Research
- Arsenic contamination and mitigation
- Plasmonic and Surface Plasmon Research
- Plant Gene Expression Analysis
- Heavy Metal Exposure and Toxicity
- Fluoride Effects and Removal
- Gold and Silver Nanoparticles Synthesis and Applications
- Photosynthetic Processes and Mechanisms
- Nanowire Synthesis and Applications
- Photonic and Optical Devices
- Histone Deacetylase Inhibitors Research
- Phonocardiography and Auscultation Techniques
- Molecular Junctions and Nanostructures
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- Ginkgo biloba and Cashew Applications
- Neonatal and Maternal Infections
- Heavy metals in environment
- Plant Parasitism and Resistance
- Neonatal and fetal brain pathology
- Bone and Dental Protein Studies
- Genomics, phytochemicals, and oxidative stress
- Control and Dynamics of Mobile Robots
- Robotics and Automated Systems
- Advanced Glycation End Products research
Affiliated Hospital of Guizhou Medical University
2016-2025
National Taiwan University
2010-2024
Institute of Molecular Biology, Academia Sinica
2018-2024
Fujian Normal University
2023-2024
Tri-Service General Hospital
2020-2023
National Defense Medical Center
2020-2023
Inner Mongolia Agricultural University
2019-2022
Ministry of Agriculture and Rural Affairs
2022
Guiyang Medical University
2013-2022
Shenyang University of Technology
2017-2018
Post-translational modifications of histones, including acetylation, play a key role in modulating dynamic changes chromatin structure and gene activity.Histone acetylation is modulated through the action histone acetyltransferases deacetylases.HDA6 RPD3-type deacetylase Arabidopsis.The Arabidopsis HDA6 mutant, axe1-5, RNAinterfering (HDA6-RNAi) plants displayed higher levels acetylated H3 compared with wild-type, suggesting that affects globally.The expression jasmonate responsive genes,...
Abstract Histone acetylation and deacetylation play an important role in epigenetic controls of gene expression. HISTONE DEACETYLASE6 (HDA6) is a REDUCED POTASSIUM DEPENDENCY3-type histone deacetylase, the Arabidopsis (Arabidopsis thaliana) hda6 mutant axe1-5 displayed late-flowering phenotype. axe1-5/flc-3 double mutants flowered earlier than plants, indicating that phenotype was FLOWERING LOCUS C (FLC) dependent. Bimolecular fluorescence complementation, vitro pull-down,...
Abstract The seed maturation genes are specifically and highly expressed during late embryogenesis. In this work, yeast two-hybrid, bimolecular fluorescence complementation, coimmunoprecipitation assays revealed that HISTONE DEACETYLASE19 (HDA19) interacted with the HIGH-LEVEL EXPRESSION OF SUGAR-INDUCIBLE GENE2-LIKE1 (HSL1), zinc-finger CW [conserved Cys (C) Trp (W) residues] domain of HSL1 was responsible for interaction. Furthermore, we found mutations in HDA19 resulted ectopic expression...
Abstract In nature, plants are exposed to a fluctuating environment, and individuals contrasting environmental factors develop different histories. Whether histories alter plant responses current stress remains elusive. Here, we show that history modulates the response microbial pathogens. Arabidopsis thaliana repetitive heat, cold, or salt were more resistant virulent bacteria than grown in stable environment. By contrast, long-term exposure high concentrations of NaCl did not provide...
The molecular mechanism of how the histone deacetylase HDA6 participates in maintaining transposable element (TE) silencing Arabidopsis (Arabidopsis thaliana) is not yet defined. In this study, we show that a subset TEs was transcriptionally reactivated and TE reactivation associated with elevated H3 H4 acetylation as well increased H3K4Me3 H3K4Me2 hda6 mutants. Decreased DNA methylation also detected mutants, suggesting silences by regulating status TEs. Similarly, transcripts some these...
Summary The acetylation level of histones on lysine residues regulated by histone acetyltransferases and deacetylases plays an important but under‐studied role in the control gene expression plants. With aim characterizing Arabidopsis RPD 3/ HDA 1 family deacetylase 5, we present evidence showing that 5 displays activity. Mutants defective displayed a late‐flowering phenotype. Expression flowering repressor genes FLC MAF was up‐regulated hda5 mutants. Furthermore, activation markers, H3 H3K4...
ASYMMETRIC LEAVES 1 (AS1) is a MYB-type transcription repressor that controls leaf development by regulating KNOX gene expression, but the underlying molecular mechanism still unclear. In this study, we demonstrated AS1 can interact with histone deacetylase HDA6 in vitro and vivo. The genes were up-regulated hyperacetylated hda6 mutant, axe1-5, indicating may regulate expression through deacetylation. Compared single mutants, as1-1/axe1-5 as2-1/axe1-5 double mutants displayed more severe...
Abstract Background Although histone deacetylases from model organisms have been previously identified, there is no clear basis for the classification of under RPD3/HDA1 superfamily, particularly on plants. Thus, this study aims to reconstruct a phylogenetic tree determine evolutionary relationships between six different plants representing dicots with Arabidopsis thaliana, Populus trichocarpa, and Pinus taeda , monocots Oryza sativa Zea mays lower Physcomitrella patens . Results Sixty two...
Histone deacetylases (HDACs) play important roles in regulating gene expression. In yeast and animals, HDACs act as components of multiprotein complexes that modulate transcription during various biological processes. However, little is known about the interacting proteins plant HDACs. To identify HDAC proteins, we developed an optimized workflow using immunopurification coupled to mass spectrometry-based proteomics Arabidopsis thaliana We found histone deacetylase HDA6 can interact with...
Currently, most arsenic (As) studies in populations are concerned with water-borne arsenicosis. However, residents Xingren County of Guizhou Province, Southwest China, represent a unique case arsenicosis which is related to indoor combustion high As-containing coal. This study aimed assess the alterations As levels and its risk factors coal-borne during past 20 years. Four follow-up investigations were selected from year 1998 2017, total 245, 272, 584, 309 involved four investigations,...
Galactolipids monogalactosyl diacylglycerol (MGDG) and digalactosyl (DGDG) constitute c. 50% 30% of chloroplast membrane lipids, respectively. They are important for photosynthesis stress tolerance. Mutations in DGD1, the major DGDG-synthesizing enzyme, severely reduce DGDG content induce jasmonic acid (JA) overproduction, resulting stunted growth. However, how reduction leads to JA overproduction is unknown. We introduced an inducible microRNA (ami-MGD1) into Arabidopsis dgd1 mutant MGDG...
Liver damage is the most severe complication of heat stress (HS). Hydrolyzed camel whey protein (CWP) possesses bioactive peptides with obviously antioxidant and anti-inflammatory activities. The current study aims to investigate whether CWP that hydrolyzed by a simulated gastrointestinal digestion process, named S-CWP, protects BRL-3A hepatocytes from HS-induced via mechanisms. cells were pretreated S-CWP before being treated at 43 °C for 1 h, levels cellular oxidative stress, inflammation,...
Parental involvement in homework is a crucial aspect of family education, but it often leads to emotional strain and conflicts that can severely impact well-being. This paper presents findings from 4-week situ study involving 78 families China, where we collected analyzed 602 valid audio recordings (totalling 475 hours) daily surveys. Leveraging large language models (LLMs) analyze parent-child conversations, gained nuanced understanding behavioural dynamics overcomes the limitations...
FVE/MSI4 is a homolog of the mammalian RbAp48 protein. We found that FVE regulates flowering time by repressing FLC through decreasing histone H3K4 trimethylation and H3 acetylation. Furthermore, interacts with deacetylase HDA6 demethylase FLD, suggesting these proteins may form protein complex to regulate time. To further investigate function FVE-FLD-HDA6 complex, we compared gene expression profiles fve, fld hda6 mutant plants using RNA-seq analysis. Among mis-regulated genes in fve...
β-Glucan from Saccharomyces cerevisiae has been described to be effective antioxidants, but the specific antioxidation mechanism of β-glucan is unclear. The objectives this research were determine whether could regulate oxidative stress through Dectin-1/Nrf2/HO-1 signaling pathway in lipopolysaccharides (LPS)-stimulated RAW264.7 cells. In study, we examined effects on enzyme activity or production indicators LPS-stimulated cells by biochemical analysis and protein expression key factors...
Wireless sensor networks (WSNs) are one of the most important ingredients in Internet Things. Thus it is vital to design a good power saving protocol, which operates at medium access control (MAC) layer, for WSN since sensors generally battery-powered. On other hand, organizing into coronas centered sink simple effective technique achieve low-overhead routing where every needs neither broadcast beacons nor maintain routing/neighbor tables. Hence this paper, we propose an optimal and...
To save manufacturing cost, most color digital video cameras employ a single-sensor technology with red-green- blue (RGB) filter array (CFA) to capture real-world scenes. Due only one primary measured at each pixel location, the captured videos are usually referred as mosaic videos. For purposes of economical storage and transmission, it is very important achieve good tradeoff between quality bitrate when compressing different RGB-CFA structures. In this paper, based on mathematical...
Long-term manganese exposure causes a neurodegenerative disorder referred to as poisoning, but the mechanism remains unclear and no specific treatment is available. Oxidative stress widely recognised one of main manganese-induced neurotoxicity. In recent years, role histone acetylation in diseases has been concerned. curcumin natural polyphenol compound extracted from rhizome turmeric exhibits both antioxidant neuroprotective properties. Therefore, we aimed investigate whether how protects...
The effect of coupled mode surface plasmon polaritons (SPPs) on the active emission a nanostructure grating with organic semiconductor material, Alq(3), was investigated in this study. We report (SPGCE) from excited layer metal both organic/metal (2-Layer) and organic/metal/organic/metal (4-Layer) structures. dispersion relation obtained angle-resolved photoluminescence measurement. resultant intensity can have up to 6 times enhancement 4- Layer device Full-Width Half-Maximum (FWHM) is less...