The molecular mechanism of how the histone deacetylase HDA6 participates in maintaining transposable element (TE) silencing Arabidopsis (Arabidopsis thaliana) is not yet defined. In this study, we show that a subset TEs was transcriptionally reactivated and TE reactivation associated with elevated H3 H4 acetylation as well increased H3K4Me3 H3K4Me2 hda6 mutants. Decreased DNA methylation also detected mutants, suggesting silences by regulating status TEs. Similarly, transcripts some these...

Lactobacillus rhamnosus GG (LGG) has been regarded as a safe probiotic strain. The aim of this study was to investigate whether dietary LGG supplementation could alleviate diarrhea via improving jejunal mucosal barrier function in the weaned piglets challenged by RV, and further analyze potential roles for apoptosis cells intestinal microbiota. A total 24 crossbred barrows at 21 d age were assigned randomly 1 2 diets: basal diet supplementing diet. On day 11, all pigs orally infused RV or...

ASYMMETRIC LEAVES 1 (AS1) is a MYB-type transcription repressor that controls leaf development by regulating KNOX gene expression, but the underlying molecular mechanism still unclear. In this study, we demonstrated AS1 can interact with histone deacetylase HDA6 in vitro and vivo. The genes were up-regulated hyperacetylated hda6 mutant, axe1-5, indicating may regulate expression through deacetylation. Compared single mutants, as1-1/axe1-5 as2-1/axe1-5 double mutants displayed more severe...

Abstract The intestine plays key roles in maintaining body arginine (Arg) homoeostasis. Meanwhile, the is very susceptible to reactive oxygen species. In light of this, study aimed explore effects Arg supplementation on intestinal morphology, transporters and metabolism, potential protective mechanism piglets under oxidative stress. A total thirty-six weaned were randomly allocated six groups with replicates fed a base diet (0·95 % Arg,) or supplemented 0·8 1·6 l- for 1 week, respectively....

Abstract Background Foxtail millet [ Setaria italica (L.) P. Beauv.] is an excellent crop known for its superior level of drought tolerance across the world. Especially, less water needed during germination period than other cereal crops. However, knowledge mechanisms underlying abiotic stress effects on seed foxtail largely unknown. Results The uptake pattern seeds was ploted period, according to which time course separated into three phases. We sequenced transcriptome seeds, were treated...

With the increasing of global mean surface air temperature, heat stress (HS) induced by extreme high temperature has become a key factor restricting poultry industry. Liver is main metabolic organ broilers, HS induces liver damage and disorders, which impairs health broilers affects food safety. As an essential trace element for animals, selenium (Se) involves in formation antioxidant system, its biological functions are generally mediated selenoproteins. However, mechanism Se against...

Oxidative stress is detrimental to animals. Previous studies have indicated that arginine (Arg) may function as a potential substance against oxidative stress. The present study was conducted explore the mechanisms behind Arg-induced protective effects in piglets. A total of thirty-six piglets were randomly allocated six groups with replicates per group. Piglets subjected three dietary treatments (namely two treatment) week 1 and fed basal diet (ArgL) or supplemented 0.8% (ArgM) 1.6% (ArgH)...

This experiment was conducted to investigate the effects of benzoic acid, Bacillus coagulans and oregano oil combined supplementation on growth performance, immune status intestinal barrier integrity piglets. In a 26-d experiment, 25 piglets were randomly assigned 5 treatments: 1) basal diet, negative control (NC), 2) NC added with antibiotics, positive (PC); 3) acid at 3,000 g/t 400 (AB); 4) (AO); 5) (ABO). On d 27, all euthanized obtain jejunal mucosa measure integrity. Results showed that...

The skeletal muscle of pigs is vulnerable to oxidative damage, resulting in growth retardation. Selenoproteins are important components antioxidant systems for animals, which generally regulated by dietary selenium (Se) level. Here, we developed the stress (DOS)-inducing pig model investigate protective effects selenoproteins on DOS-induced retardation.Dietary caused porcine damage and retardation, accompanied mitochondrial dysfunction, endoplasmic reticulum (ER) stress, protein lipid...

Hydroxymethionine manganese (MnHMet), as a novel organic trace element additive, has demonstrated significant effects on improving meat quality, enhancing antioxidant capacity, and lipid metabolism. However, its specific Cherry Valley ducks remain unclear. This study explored the of dietary MnHMet metabolism in ducks. In 35-day study, 560 1-day-old male were randomly assigned to seven groups: six groups supplemented at 0, 30, 60, 90, 120, 150 mg/kg, group was 120 mg/kg MnSO 4 . Results...

The aim of the present study was to determine whether early weaning-induced growth retardation could be attenuated by increased consumption methionine as dl -methionine (DLM) or -2-hydroxy-4-methylthiobutyrate (HMTBA) in both lactating sows and weaned piglets. Therefore, diets containing DLM HMTBA at 25 % total sulphur-containing amino acids (AA) control (CON) diet were fed piglets their responses evaluated. Compared with CON diet-fed sows, exhibited a tendency ( P < 0·10) towards higher...

This study was to investigate the effects of dietary supplementation Bacillus coagulans (BC) and yeast hydrolysates (YH) on growth performance, antioxidant activity, cytokines intestinal microflora growing-finishing pigs. Thirty-six barrows (initial BW = 26.87 ± 2.65 kg) were assigned randomly 3 treatments with 4 replicates, pigs per replicate. Pigs in control group (CON) fed a basal diet, diets for other 2 groups diet plus BC at 200 mg/kg YH 3,000 mg/kg. The trial lasted 104 d. Compared...

This study was conducted to determine the effects of different dietary protein levels and amino acids supplementation patterns in low diets on growth performance, carcass characteristics nitrogen excretion growing-finishing pigs.Forty-two barrows (25.00 ± 0.39 kg) were randomly assigned 7 diets. Diet 1: high crude diet with balanced for 10 essential (EAAs). 2: medium 2% (approx) decreased level 1 EAAs. 3: 4% The 4, 5, 6 same as that 3. 4 only lysine (Lys), methionine (Met), threonine (Thr)...

Abstract The present study compared the protective effect of sodium selenite (SS) and selenomethionine (SeMet) on heat stress (HS)-invoked porcine IPEC-J2 cellular damage integrate potential roles corresponding selenoprotein. Cells were cultured at 37°C until 80 % confluence then subjected to four different conditions for 24 h: (control), 41·5°C (HS), supplied with 0·42 µmol Se/L SS (SS), or SeMet (SeMet). HS significantly decreased cell viability, up-regulated mRNA protein levels shock 70...

Tryptophan can alleviate stress and improve intestinal health, but the precise mechanism has not been fully elucidated. This study aimed to examine effects of tryptophan supplementation on antioxidant status, inflammation, endoplasmic reticulum (ER) stress, apoptosis, pyroptosis signaling pathway in intestine piglets after Escherichia coli lipopolysaccharide (LPS) challenge. Thirty-two weaning were allotted four treatments including: non-challenged control, LPS-challenged LPS + 0.2% 0.4%...

Intestinal inflammation is the main risk factor causing intestinal barrier dysfunction and lipopolysaccharide (LPS) can trigger inflammatory responses in various eukaryotic species. Yeast hydrolysate (YH) possesses multi-biological effects received remarkable attention as a functional ingredient for improving growth performance promoting health animals. However, there still inconclusive on protective of dietary YH supplementation piglets. This study was conducted to investigate attenuate...

The thymus and spleen, the main reservoirs for T lymphocytes, modulate innate immune response. Oxidative stress, excessive inflammation abnormal pyroptosis can cause dysfunction of these organs. This study aimed to examine whether tryptophan supplementation improve growth performance mitochondrial function via adenosine 5'-monophosphate-activated protein kinase (AMPK)/sirtuin1 (Sirt1)/peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) signalling pathway decrease...

Plant cell walls are mainly composed of polysaccharides such as cellulose and callose. Callose exists at a very low level in the wall; however, it plays critical roles different stages plant development well defence against unfavorable conditions. is accumulated plate, plasmodesmata male female gametophytes. Despite important callose plants, mechanisms its synthesis regulatory properties not understood. CALLOSE SYNTHASE (CALS) genes, also known GLUCAN SYNTHASE-LIKE (GSL), comprise family 12...

Impaired intestinal barrier integrity plays a crucial role in the development of many diseases such as obesity, inflammatory bowel disease, and type 2 diabetes. Thus, protecting from pathological disruption is great significance. Tryptophan can increase gut integrity, enhance absorption, decrease inflammation. However, mechanism tryptophan decreasing damage response remains largely unknown. The objective this study was to test hypothesis that epithelial mediated by calcium-sensing receptor...