Abstract Background Although histone deacetylases from model organisms have been previously identified, there is no clear basis for the classification of under RPD3/HDA1 superfamily, particularly on plants. Thus, this study aims to reconstruct a phylogenetic tree determine evolutionary relationships between six different plants representing dicots with Arabidopsis thaliana, Populus trichocarpa, and Pinus taeda , monocots Oryza sativa Zea mays lower Physcomitrella patens . Results Sixty two...

Class II histone deacetylases in humans and other model organisms undergo nucleocytoplasmic shuttling. This unique functional regulatory mechanism has been well elucidated eukaryotic except plant systems. In this study, we have paved the baseline evidence for cytoplasmic nuclear localization of HDAs as their mRNA expression patterns. RT-PCR analysis on different vegetative parts developmental stages reveal that are ubiquitously expressed all tissues with minimal specificity. Moreover, stable...

Acquired drug resistance is a primary obstacle for effective cancer therapy. The correlation of point mutations in class III β-tubulin (TUBB3) and the prominent overexpression ATP-binding cassette P-glycoprotein (ABCB1), multidrug gene, have been protruding mechanisms to microtubule disruptors such as paclitaxel (PTX) many cancers. However, precise underlying mechanism rapid onset cross-resistance an array structurally functionally unrelated drugs PTX-resistant cancers has poorly understood....

Abstract Mercury-binding peptides from roots, stems, and leaves of Hg-treated Chromolaena odorata plants were isolated partially characterized using RP-HPLC ESI-MS. Upon exposure C. to high concentrations 1.0 2.0 μᴍ Hg(NO 3 ) 2 treatments 0-28 days, they accumulated as much 125 mg/g (dry wt) Hg in the 15.280 0.800 indicating that has a potential phytoremediation agent inorganic mercury. The plant’s ability accumulate sequester ions was primarily attributed production Hgbinding peptides,...

With its high nutritional and bioactive content, bee pollen is recognized as a functional food. However, composition highly dependent on range of factors, such geographical location. In this research, we used DPPH to determine the antioxidant activity several stingless (Tetragonula biroi) samples sourced from five different areas in Philippines compare their phenolic flavonoid content. Additionally, compared two extraction methods: maceration (or soaking samples) for three days sonication 30...

The first species of the genus Neurigona is described from Philippines. diagnosis, description and molecular data based on partial DNA sequence mitochondrial cytochrome oxidase subunit I gene were documented. exhibits distinct characteristics, including a sub-apical dorsal stylus resembling an arista, peduncle seventh abdominal segment, flat postcranium, elongated legs devoid prominent setae or bristles, distinctive rectangular bend in wing vein M. Based analysis, unknown 90.06% similar to...

The Philippines is the second biggest source of skipjack tuna (Katsuwonus pelamis), contributing to country’s economic development. However, its sustainability faces challenges due overfishing and a lack proper management practices. Otoliths are important tools for managing fish stocks, but their analysis time-consuming requires high level expertise. In this paper, we explored use convolutional neural networks (CNNs) recognize patterns classify them according developmental stages. results...

Abstract Breast cancer is considered as one of the three most common cancers around world and second leading cause deaths among women. Coix lachrymal jobi, commonly known Job’s tears or adlay has been reported to possess anti-cancer properties. Despite evidences provided by clinical data, usage lacryma-jobi in treating cancer, particularly breast scarce. Thus, this study was conducted determine pharmacological mechanisms underlying its anti-breast property using various network pathway...

Rhizospheric bacteria (PGPR) associated with 5 banana cultivars planted in SOCCSKSARGEN were studied. Microbial population newly established and old plantation was compared. Bacteria purified their beneficial characteristics determined. This study able to collect one hundred twenty (120) bacterial isolates, 20 (17%) of which nitrogen-fixers, nineteen (19/20) phosphate solubilizers seventeen (17/20) IAA producers. From this study, five isolates coded PE05, RS10, PE11, PE13, PE18 found...

ABSTRACT Light is an essential environmental cue that determines the overall growth and development of plants. However, molecular mechanisms underpinning light signaling network are obscured by epigenetic machinery where reversible acetylation deacetylation play crucial roles in modulating light-regulated gene expression. In this paper, we demonstrate HDA15 represses COP1, master switch network, deacetylation, protein interaction, sub-compartmentalization. hda15 T-DNA mutant lines exhibited...

A new fly species, Chrysosoma nellyae, has been recently discovered in Bohol, Philippines. Aside from the metallic blue head with black antennae which are reminiscent of its thorax is a greenish and brown prescutellar patch, scutellum brown, green border hair like bristle. In addition, based on similarity male genitalia, cercus morphology, legs, species appears to be related C. crinicorne. To increase accuracy identification, DNA barcoding mitochondrial cytochrome oxidase I gene was employed...

Abstract Light is an essential environmental cue that determines the overall growth and development of plants. However, molecular mechanisms underpinning light signaling network are obscured by epigenetic machinery where reversible acetylation deacetylation play crucial roles in modulating light-regulated gene expression. In this paper, we demonstrate HDA15 represses COP1, master switch network, deacetylation, protein interaction, sub-compartmentalization. hda15 T-DNA mutant lines exhibited...

ABSTRACT Philippine scombrids have been among the top priorities in fisheries research due primarily to their economic value worldwide. Assessment of number studies under general themes (diversity, ecology, taxonomy and systematics, diseases parasites, conservation) provides essential information evaluate trends gaps research. This study presents a bibliometric evaluation temporal from 2000-2019 on scombrid Seven out nine tuna species SREA values equal or higher than 1 with Thunnus albacares...

There has been a concerning increase in the incidence of autoimmune diseases following SARS-CoV-2 infection, with molecular mimicry proposed as potential mechanism. Our study identified nine fertility-associated proteins (AMH, BMP2, CUBN, DNER, ERCC1, KASH5, MSLN, TPO, and ZP3) that exhibit MHC-II epitopes (N, ORF1A, ORF1AB, S). We screened for based on silico binding using DR-, DQ-, DP-haplotypes predispose susceptible individuals to diseases. systematic analysis revealed 41 countries...

Herbal teas are widely consumed for their health benefits. In this study, the phenolic content and antioxidant capacity of six commercially available banaba (Lagerstroemia speciosa) sambong (Blumea balsamifera) herbal were analyzed. The activity was measured using DPPH ABTS assays, with L. speciosa exhibiting higher than B. balsamifera teas. determined Folin-Ciocalteu method showed a direct correlation activity. market prices based on unit varied different brands sold online indicating need...

Abstract Diabetes mellitus (DM) is the most common endocrine disorder and among top 10 leading diseases causing death worldwide. Coicis semen [CS] ( Coix lacryma-jobi ), also known as adlay have been reported to display anti-diabetic properties. Unfortunately, studies on pharmacological mechanisms involving for treatment of diabetes are nil. Thus, this study was conducted evaluate interactions bioactive compound targets in using network analysis. Adlay compounds potential target genes were...