A5043466702- Advanced biosensing and bioanalysis techniques
- Plasmonic and Surface Plasmon Research
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Photonic and Optical Devices
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Optical Coatings and Gratings
- Molecular Junctions and Nanostructures
- Analytical Chemistry and Sensors
- Graphene research and applications
- Carbon and Quantum Dots Applications
- Monoclonal and Polyclonal Antibodies Research
- Gas Sensing Nanomaterials and Sensors
- Acoustic Wave Resonator Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Nonlinear Optical Materials Studies
- SARS-CoV-2 detection and testing
- Electrochemical Analysis and Applications
- Advanced Chemical Sensor Technologies
- ECG Monitoring and Analysis
- SARS-CoV-2 and COVID-19 Research
- Nanofabrication and Lithography Techniques
- Extracellular vesicles in disease
National Taiwan Normal University
2015-2024
Electro Optical Systems (Germany)
2011-2018
National Taiwan University
2004-2017
Optica
2010-2011
National Taiwan University Hospital
2010
National Yang Ming Chiao Tung University
2010
We report that gold/zinc oxide (Au/ZnO) nanocomposite films were effectively employed to enhance the performance of surface plasmon resonance (SPR) for detection tumor markers. Carbohydrate antigen 15.3 (CA15-3), a marker breast cancer, was chosen as model analyte. analyzed intensity response samples at various concentrations (0.0125 U/mL 160 U/mL) in pleural fluid evaluate capability SPR biosensor based on Au/ZnO thin films. The linear range extended from 1 40 with correlation coefficient...
Due to educational, social and economic reasons, more women are delaying childbirth. However, advanced maternal age is associated with several adverse pregnancy outcomes, in particular a high risk of Down's syndrome (DS). Hence, it increasingly important be able detect fetal (FDS).We developed an effective, highly sensitive, surface plasmon resonance (SPR) biosensor biochemically amplified responses using carboxyl-molybdenum disulfide (MoS2) film. The use carboxylic acid as modifier MoS2...
This work develops a highly sensitive immunoassay sensor for use in graphene oxide sheet (GOS)-based surface plasmon resonance (SPR) chips. sensing film, which is formed by chemically modifying GOS surface, has covalent bonds that strongly interact with the bovine serum albumin (BSA), explaining why it higher sensitivity. film-based SPR chip BSA concentration detection limit 100 times than of conventional Au-film-based sensor. The affinity constants (K A) on and μg/ml are 80.82 × 10(6) M(-1)...
We constructed a novel surface plasmon resonance (SPR) detection assay using carboxyl-functionalized molybdenum disulfide (carboxyl-MoS2) nanocomposites as signal amplification sensing film for the ultrasensitive of lung cancer-associated biomarker cytokeratin 19 fragment (CYFRA21-1). The experiment succeeded in MoS2 reacted with chloroacetic acid giving carboxyl-MoS2 reaction product. additional shoulder C 1s and O peaks carboxyl-MoS2, which were increased X-ray photoelectron spectroscopy,...
Since graphene was first isolated in 2004, research related to graphene-based 2D material for surface plasmon resonance (SPR) biosensor applications has increased. Recently, other types of materials such as Transition Metal Dichalcogenides have also been investigated. This exceptional optical and electronic properties can be utilized improve the performance biosensors. The SPR biosensors determined based on their sensitivity detection accuracy (DA). To find out DA, simulation approach done....
The use of functionalized graphene oxide (fGO) has led to a new trend in the sensor field, owing its high sensitivity with regards sensing characteristics and easy synthesis procedures.In this study, we developed an ultra-sensitive carboxyl-graphene (carboxyl-GO)-based surface plasmon resonance (SPR) aptasensor using peptides detect human chorionic gonadotropin (hCG) clinical serum samples. carboxyl-GO based SPR provided affinity stronger binding peptides, which are great importance allow...
We report a novel design wherein high-refractive-index zinc oxide (ZnO) intermediary layers are used in anti-symmetrically structured surface plasmon resonance (SPR) devices to enhance signal quality and improve the full width at half maximum (FWHM) of SPR reflectivity curve. The (SP) modes ZnO layer were excited by irradiating both sides Au film, thus inducing high electric field Au/ZnO interface. demonstrated that an improvement (002) crystal orientation led decrease FWHM curves. optimized...
In this study, we propose a modified gold nanoparticle-graphene oxide sheet (AuNP-GO) nanocomposite to detect two different interactions between proteins and hybrid nanocomposites for use in biomedical applications. GO sheets have high bioaffinity, which facilitates the attachment of biomolecules carboxyl groups has led its development sensing mechanisms. When are decorated with AuNPs, they introduce localized surface plasmon resonance (LSPR) energy transfer spectral changes. Our results...
This letter is intended to demonstrate the effect of coupled active long-range surface plasmon polaritons (SPPs) on plasmonics response a lamellar grating nanostructure with organic material surface. The phenomenon nano-optics gives rise selective spectral and local field enhancement. authors’ fabricated device consists organic/metal specific width symmetric dielectric structure. interaction between interface SPPs can allow directional emission rather than isotropic emission. authors present...
The effect of coupled mode surface plasmon polaritons (SPPs) on the active emission a nanostructure grating with organic semiconductor material, Alq(3), was investigated in this study. We report (SPGCE) from excited layer metal both organic/metal (2-Layer) and organic/metal/organic/metal (4-Layer) structures. dispersion relation obtained angle-resolved photoluminescence measurement. resultant intensity can have up to 6 times enhancement 4- Layer device Full-Width Half-Maximum (FWHM) is less...