A5100389079- Antibiotic Resistance in Bacteria
- Plant Stress Responses and Tolerance
- Chemotherapy-induced cardiotoxicity and mitigation
- Photosynthetic Processes and Mechanisms
- Bioactive natural compounds
- Cancer Treatment and Pharmacology
- Calpain Protease Function and Regulation
- Chemical Synthesis and Analysis
- Plant Gene Expression Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant biochemistry and biosynthesis
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Essential Oils and Antimicrobial Activity
- Protease and Inhibitor Mechanisms
- Ginger and Zingiberaceae research
- CRISPR and Genetic Engineering
- Cloud Computing and Resource Management
- Cardiac Imaging and Diagnostics
- Natural product bioactivities and synthesis
- Hops Chemistry and Applications
- Cancer therapeutics and mechanisms
- Plant responses to elevated CO2
- Cancer-related Molecular Pathways
First Affiliated Hospital of Hebei Medical University
2024-2025
Hebei Medical University
2024-2025
Wuhan Polytechnic University
2024-2025
Second Affiliated Hospital of Zhejiang University
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2024
Wuhan University
2023
Sichuan Agricultural University
2022-2023
Ministry of Natural Resources
2023
Fujian University of Traditional Chinese Medicine
2023
Nanjing Forestry University
2022
The global transmission of carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant and grave threat to human health. To investigate the potential relationship between hospital sewage CRAB within healthcare facilities, isolates spp. obtained from untreated samples were subjected antimicrobial susceptibility tests, genome sequencing, bioinformatic phylogenetic tree analysis, that data matched with those clinical isolates. Among 70 tested, A. was most prevalent detectable in 5...
The impact of ZnO as a feed additive on growth-performance and intestinal function Enterotoxigenic Escherichia coli (ETEC) K88-infected piglets remains unclear. Fecal scores in ETEC group were significantly increased compared to control group. K88 damages the small intestine, including reduction villus height jejunum, duodenum, ileum, decrease total superoxide dismutase activity jejunum catalase ileum jejunum. Compared group, infection elevated mRNA level gene IL-1β ileal epithelial cell...
Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that seriously harms the swine industry and human health. However, its pathogenic mechanisms are largely unknown, several virulence factors reported so far insufficient to systematically explain infectious mechanisms. In preliminary research, we identified a gene named G22 encoding hypothetical secreted protein may be closely associated with high-level pathogenicity of S. suis. this study, constructed deletion...
Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that seriously harms the swine industry and human health. However, its pathogenic mechanisms are largely unknown, few virulence factors reported so far insufficient to systematically explain infectious mechanisms. In preliminary research, we identified a gene named G22 encoding hypothetical secreted protein may be closely associated with high-level pathogenicity of S. suis. this study, constructed deletion complementation...
Abstract The extracellular matrix protein fibronectin (FN) facilitates tumorigenesis and the development of breast cancer. Inhibition FN-induced cellular response is a potential strategy for cancer treatment. In present study, we investigated effects flavonoid baicalein on epithelial–mesenchymal transition (EMT) in MCF-10A epithelial cells transgenic mouse MMTV-polyoma middle T antigen model (MMTV-PyMT). Baicalein inhibited migration, invasion, F-actin remodeling. also suppressed...
Src homology 2 (SH2) domains mediate protein–protein interactions by recognizing phosphotyrosine (pY)-containing sequences of target proteins. In all the SH2 domain–pY peptide described to date, domain binds a single pY peptide. Here, determination cocrystal structure N-terminal phosphatase SHP-2 bound class IV (VIpYFVP) revealed noncanonical 1:2 (protein–peptide) complex. The first in canonical manner with its side chain inserted usual binding pocket, while second pairs up form two...
Oxymatrine, an alkaloid extracted from the Chinese herb Sophora flavescens Aiton, possesses anti-inflammatory, anti-immune, anti-hepatic fibrosis, and anti-cancer properties. However, effects of oxymatrine on epithelial-mesenchymal transition (EMT) breast cancer cells are still unclear.The present study was performed to investigate whether reverses EMT in explore underlying molecular mechanisms.MTT assay evaluate cell viability. Wound-healing transwell chamber were used assess migration...
The combination of chemotherapy with natural products is a common strategy to enhance anticancer effects while alleviating the dose-dependent adverse cancer treatment. Oxymatrine (OMT) has been extensively reported as having activity. Doxorubicin (DOX) chemotherapeutic DNA-damaging agent used for treatment carcinoma. In this study, we investigated whether synergistic exist OMT and DOX using human colorectal cell (CRC) lines potential mechanisms involved in vitro vivo activities. MTT colony...
Alpinia zerumbet is a miao folk medicinal plant widely used in the Guizhou Province of southwest China that contains several bioactive constituents and possesses protective effects against cardiovascular diseases. In present study, we evaluated effect essential oils derived from Fructus Alpiniae (EOFAZ) on oxidized lowdensity‐lipoprotein‐ (ox‐LDL‐) induced apoptosis human aortic endothelial cells (HAECs). Following exposure to ox‐LDL, HAECs presented with classical characteristics apoptosis....
Porcine extraintestinal pathogenic
Singlet oxygen (
Due to their roles in amino acid metabolism and close evolutionary relationship, arginine lysine biosynthetic pathways represent interesting models for probing functional specialization of metabolic routes. The current knowledge with respect biosynthesis is limited haloarchaea compared that bacteria hyperthermophilic archaea.
Chemotherapy-induced cardiotoxicity poses a significant challenge in the treatment of breast cancer, potentially compromising both efficacy cancer therapy and cardiac health patients. This study aimed to enhance early detection cardiotoxic effects by integrating advanced imaging modalities biomarker analysis, thereby facilitating timely interventions mitigate risk.
Global transmission of carbapenem-resistant Acinetobacter baumannii poses a severe threat to human health. There is speculation that wastewater the key medium through which A. disseminate in both hospital and natural environment. To test this theory, spp. strains obtained from sewage samples were subjected antimicrobial susceptibility tests, genome sequencing, bioinformatic phylogenetic tree analysis, data matched with those clinical strains. The found exhibit diverse genetic profile. Among...
This study aims to explore the molecular regulation mechanism of differential accumulation flavonoids in leaves and roots Sarcandra glabra. Liquid chromatography-mass spectrometry(LC-MS) high-throughput transcriptome sequencing(RNA-seq) were employed screen out flavonoid-related metabolites differentially expressed genes(DEGs) encoding key metabolic enzymes. Eight DEGs randomly selected for qRT-PCR verification. The results showed that a total 37 between S. glabra obtained, including...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Simultaneous Binding of Two Peptidyl Ligands by Src Homology 2 DomainYanyan Zhang, Jinjin Chunhua Yuan, Ryan L. Hard, In-Hee Park, Chenglong Li, Charles Bell, and Dehua Pei*Cite this: Biochemistry 2011, 50, 39, 8519Publication Date (Web):September 6, 2011Publication History Received30 August 2011Published online6 September inissue 4 October...
Abstract Background: Endothelial Mesenchymal Transformation (EndMT) contributes to the development of cardiovascular disease. Krüpple factor 4 (KLF4) is a zinc finger transcription whose N-terminus can recruit acetyltransferase promote histone acetylation, thereby affecting activation downstream genes. Our previous studies have shown that EOFAZ has protective effects on HUVECs oxidative stress induced by TGF-β 1 . However, whether effect EndMT and it related regulation signals KLF4 not yet...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract Singlet oxygen (1O2) has a very short half-life of 10−5 s; however, it is strong oxidant that causes growth arrest and necrotic lesions on plants1–4. Its signaling pathway remains largely unknown. The Arabidopsis flu (FLUORESCENT) mutant accumulates high level 1O2 shows drastic changes in nuclear gene expression5. Only two plastid proteins, EX1 (EXECUTER 1) EX2 2), have been identified the singlet signaling6,7. Here we found transcription factor ABI4 (ABSCISIC ACID INSENSITIVE 4)...