Abstract In the present study, we examined factors affecting survival of women with inflammatory breast cancer (IBC) and constructed validated a nomogram to predict overall (OS) in these patients. The cohort was selected from Surveillance, Epidemiology, End Results (SEER) program between 1 January 2004 31 December 2013. Univariate multivariate Cox proportional hazards regression models were constructed. A developed based on significant prognostic indicators OS. discriminatory predictive...

It has previously been demonstrated that multiple microRNAs (miRNAs or miRs) are aberrantly expressed in retinoblastoma (RB) and contribute to RB initiation progression. miR‑382 revealed be therefore exhibits a key role the progression of various types cancer. However, expression pattern, functional roles underlying molecular mechanism remain unknown. The present study investigated levels its effects on cells regulatory action. was downregulated tissues cell lines. Upregulation inhibited...

Background: Long noncoding RNA (lncRNA) deleted in lymphocytic leukemia 1 (DLEU1) was reported to be involved the development and progression of multiple cancers. However, accurate expression pattern, biological function potential molecular mechanism DLEU1 glioma are not yet known. The present study investigated role DLEU glioma, as well played by glioma. Materials methods: levels DLEUI tissues cell lines were examined using quantitative real-time PCR. effects on proliferation, mobility,...

Both wrapper and hybrid methods in feature selection need the intervention of learning algorithm to train parameters. The preset parameters dataset are used construct several sub-optimal models, from which final model is selected. question how evaluate performance these models? What effects different evaluation on result selection? Aiming at problem predictive models selection, we chose a algorithm, FDHSFFS, conducted comparative experiments four UCI datasets with large differences dimension...

Abstract The prognostic role of marital status on colorectal signet ring cell carcinoma (SRCC) has not been studied. In this study, the correlation with prognosis SRCC was analyzed. Eligible subjects were extracted from Surveillance, Epidemiology, and End Results (SEER) dataset 2004 to 2015, followed by comparison cancer-specific survival (CSS) overall (OS) between married unmarried group. 3152 patients identified including 1777 (56.38%). Married populations tended be more aged < 65,...

We aimed to evaluate the prognostic value of clinical and pathologic factors in rectal squamous cell carcinomas (SCC) construct a nomogram for their outcome prediction.The study cohort was selected from Surveillance, Epidemiology, End Results (SEER) program between January 2004 December 2013. Univariate multivariate analyses were performed using Cox proportional hazards regression model involved variables. All combined predict overall survival (OS), followed by discrimination as well...

Marriage has been reported as a beneficial factor associated with improved survival among cancer patients, but conflicting results have observed in cervical adenocarcinoma (AC). Thus, this study is aimed to examine the relationship between prognosis of AC and marital status. Eligible patients were selected from 2004 2015 using surveillance, epidemiology end (SEER) database. Cancer-specific (CSS) overall (OS) compared married unmarried groups. A total 3096 had identified, ones accounting for...

Abstract To construct and validate a nomogram to predict the overall survival (OS) of colorectal signet ring cell carcinoma (SRCC). The potentially eligible cases were obtained against SEER database from 2004 2015. Log-rank test Cox analysis conducted identify independent prognostic factors for predicting OS. identified later integrated construction an OS prediction nomogram. Altogether 2904 identified, median time was 18 (range: 0–155) months. As suggested by multivariate analysis, age,...

Zoledronic acid is used to treat patients with bone metastasis, but the optimal dosing interval remains controversial. We therefore performed a systematic review and meta-analysis compare efficacy safety of 12-week zoledronic standard 4-week interval. Three randomized controlled trials comprising 2650 were analyzed. Using random-effects model, pooled risk ratios (RRs) 95% confidence intervals (CIs) calculated. No differences in occurrence skeletal-related events (SREs: RR = 0.98; CI...

Studies have demonstrated that a number of microRNAs (miRNAs) are dysregulated in pancreatic ductal adenocarcinoma (PDAC), and alterations their expression may affect the onset progression PDAC. Therefore, patterns, biological functions associated molecular mechanisms miRNAs PDAC should be elucidated for development novel therapeutic methods. Previous studies reported significant miRNA‑874 (miR‑874) dysregulation multiple types human cancer. However, pattern, possible roles underlying...

The survival benefit of postmastectomy radiotherapy (PMRT) has not been fully proven in inflammatory breast cancer (IBC). Thus, the present research, we aimed at elucidating effects PMRT on IBC patients.Eligible patients were collected from Surveillance, Epidemiology, and End Results (SEER) dataset between 2010 2013. Kaplan-Meier method along with log-rank test was utilized for comparison both overall (OS) andthe cancer-specific (CSS) undergoing or not. Additionally, multivariate analysis...

The aim was to construct and verify a nomogram-based assessment of cancer-specific survival (CSS) in patients with colorectal signet ring cell carcinoma after surgery. Patients were collected from Surveillance, Epidemiology, End Results program between 2004 2015. Independent prognostic indicators determined the training cohort by Cox regression model. We identified 2217 eligible patients, who further categorized into set (n = 1693) as well validation 524). Multivariate analysis revealed that...

Abstract Objectives The effect of marital status on the prognosis intrahepatic cholangiocarcinoma (ICC) has not been strictly studied. Therefore, present study focused exploring whether was related to ICC prognosis. Methods This chose cases from Surveillance, Epidemiology, and End Results (SEER) database during 2004–2015 period. Cancer - specific survival (CSS) overall (OS) were compared between married unmarried groups. We enrolled 4550 eligible cases, among them, 2760 (60.66%). Married...

This study aimed to develop and validate a nomogram for predicting the overall survival of cervical adenocarcinoma (CAC) patients using large database comprising with different ethnicities. We enrolled primary CAC cases complete clinicopathological data from Surveillance, Epidemiology, End Results program during 2004 2015. For training set samples, this work applied Cox regression model obtain factors independently associated patient prognosis, which could be incorporated in constructing...

Objective To investigate the effects of angle external jugular vein on incidence PICC complications. Methods A total 212 patients with tube from August 2013 to November 2015 were divided into acute type (100 cases) and obtuse (112 according by X-ray. complications two groups evaluated. Results There 4 cases mechanical phlebitis, 2 thrombosis 0 case infection in group, while group there 19 9 infection. Statistically significant differences observed between (χ2=13.01, 5.58, 4.57;...

Abstract In recent years, structural optimization design and computer-aided methods have achieved long-term development. order to achieve innovation, improve product performance, reduce production costs, enterprise pay more attention the new methods. Optimization has become key process of Especially in fields aerospace, automobile that focus on lightweight fuel saving, scope depth topology is rapidly developing. this paper, been applied aircraft flip spreader, using ANSYS Workbench software...

Abstract Objective: To evaluate the prognostic value of age on colorectal signet ring cell carcinoma (SRCC) and identify prognosis factors patients aged ≥ 65 years. Methods : Patients were recruited from Surveillance, Epidemiology, End Results (SEER) database. We ensured that all characteristics well balanced through adopting propensity score matching (PSM) method. In addition, evaluated by Cox proportional hazardous model. Altogether 3305 cases enrolled, including 1564 in elderly group...

Abstract Due to the significant speed advantage, air freight has become preferred long-distance transportation method for precision electronic instruments and other high-value products. In order avoid impact of load conditions on safety cargo aircraft, it is necessary calculate check carrying capacity package. this paper, finite element analysis been applied design an Firstly, make force analyze, use maximum static solve stress distribution. Then, modal random vibration obtain 3σ...