A5100457575- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cholesterol and Lipid Metabolism
- Hormonal Regulation and Hypertension
- Chronic Lymphocytic Leukemia Research
- Peroxisome Proliferator-Activated Receptors
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Diabetes and associated disorders
- Renin-Angiotensin System Studies
- Helicobacter pylori-related gastroenterology studies
- Immune Response and Inflammation
- Esophageal and GI Pathology
- Chronic Kidney Disease and Diabetes
- Hernia repair and management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Renal Diseases and Glomerulopathies
- Growth Hormone and Insulin-like Growth Factors
Peking University
2016-2025
Beijing Dao Pei Hospital
2024-2025
Peking University People's Hospital
2016-2025
Xi'an Jiaotong University
2024
Macao Polytechnic University
2024
Tianjin Medical University
2024
Second Hospital of Tianjin Medical University
2024
Jiangnan University
2024
Academy of Military Medical Sciences
2023
UK Dementia Research Institute
2023
In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces weight loss, colon length, and alleviated microscopic appearances colitis induced by dextran sulfate sodium. This compound also decreases levels TNF-α, IL-6, IL-1β in intestinal tissue mice with a concentration-dependent manner. treatment epithelial cells increases expression antimicrobial peptides survival intracellular Salmonella typhimurium. These results...
Colorectal surgery is associated with high rates of surgical site infection (SSI). We investigated SSI in radical resection colon or rectal carcinoma and its epidemiological distribution 26 hospitals China.We conducted prospective surveillance patients who underwent selected from January 2015 to June 2016.An information system monitored all the inpatients. Infection control professionals observed inpatients suspected had been screened by at bedside. The status incisions was followed up...
Venetoclax (Ven) and posaconazole (PSZ) are commonly co-administered in patients with hematological diseases, including acute myeloid leukemia, chronic lymphocytic other related conditions. Due to CYP3A inhibition by PSZ, Ven plasma concentrations (ConcVen) elevated, necessitating dose adjustments. This study aimed quantitatively characterize the relationship between PSZ exposure pharmacokinetics through retrospective analysis of data from receiving concurrent therapy. We examined...
Abstract The purpose of the study was to evaluate relationship between arginine-levodopa-induced growth hormone (GH) secretion and nonalcoholic fatty liver disease (NAFLD) in obese children. This includes a total 84 43 normal weight subjects are divided into two groups based on presence or absence NAFLD. Clinical examination, anthropometric laboratory examinations, ultrasonography assessed for all participants. group had significantly lower peak stimulated GH (p<0.001) insulin-like factor...
Laparoscopic procedures for pediatric inguinal hernia (PIH) have numerous techniques and continue to evolve, with a trend toward increasing use of extracorporeal knotting decreasing working ports endoscopic instruments. Single-port laparoscopic percutaneous extraperitoneal closure (SPLPEC) variable devices seems be one the most simple reliable methods. Here authors describe evaluate applicable effects SPLPEC using an innovative two-hooked core apparatus.Between June 2008 October 2011, 72...
Sex differences in hypertension are not well known. The present study was undertaken to detect the association of nine lipid-related gene polymorphisms and blood pressure variation beween men women Bai Ku Yao population. Genotyping ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low-density lipoprotein receptor (LDL-R) AvaII, hepatic lipase (LIPC) –250G>A, endothelial (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR)...
Abstract Aims Alström syndrome (AS) is a rare recessive disorder characterised by diabetes, obesity, insulin resistance (IR), and visual hearing impairments. Mutations in the ALMS1 gene have been identified as causative agents of AS. This study aimed to explore relationship between variants clinical features Chinese patients with early‐onset type 2 diabetes (age at diagnosis ≤40 years; EOD). Materials Methods sequencing was performed 611 individuals EOD, 36 postprandial hyperinsulinemia, 47...
miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause might involved in development primary liver neoplasm. Differences miR-122 among different types have not been studied. This study aimed investigate differences serum levels Chinese patients forms diabetes, including T2DM, 1 (T1DM), variant-induced (HNF1A-DM), glucokinase...
Abstract Background ABCC8 variants cause neonatal diabetes, maturity onset diabetes of the young (MODY), and hyperinsulinemic hypoglycemia because activating or inactivating variants. In this study we used targeted exon sequencing to investigate genetic phenotypic features in Chinese patients with early (EOD). Methods A cross‐sectional 543 EOD was recruited exons them were conducted sequencing. The pathogenicity defined according American College Medical Genetics Genomics Association for...
This research investigated whether the psychoacoustics of simultaneous masking, which are integral to a model-checking-based method, previously developed for detecting perceivability problems in alarm configurations, could predict when IEC 60601-1-8-compliant medical sounds audible.The tonal nature prescribed by 60601-1-8 makes them potentially susceptible masking: where concurrent render one or more inaudible due human sensory limitations. No work has experimentally assessed masking...
We propose an artificial-pancreas-like algorithm (AP-A) that could automatically determine the preprandial insulin dose based on intermittently scanned continuous glucose monitoring (isCGM) data trajectories in multiple injection (MDI) therapy.
Nanosized metallo-supramolecular compounds, [Ni2 L3 ](4+) and [Fe2 , can not only strongly inhibit Aβ aggregation but also reduce the peroxidase activity of Aβ-heme. Further studies demonstrate that through blocking heme-binding site, these two compounds suppress Aβ-induced biosynthesis heme iron uptake in PC12 cells. This work provides new insights into molecular mechanisms inhibitors on Aβ-mediated neurotoxicity.
Purpose: We aimed to ascertain the association between thyrotropin (TSH) levels in euthyroid state and prevalence of metabolic syndrome (MetS) a community-based Chinese population. Participants Methods: Based on large well-characterized community cohort Beijing, China, 1831 men 1742 women with serum TSH within reference range (0.50– 4.78 μIU/mL) were stratified by quartiles (Q1-4). MetS was identified according criteria International Diabetes Federation guidelines. Poisson regression models...
Abstract Background The rapid and accurate detection of thyroid-stimulating hormone (TSH) receptor antibodies has always been an urgent need for the clinical diagnosis management Graves’ disease (GD). We aimed to evaluate use automated immunoglobulin (TSI) bridge immunoassay in GD analyze relationship between TSI degree hyperthyroidism. Methods A total 227 new-onset patients, 29 Hashimoto thyroiditis, 43 non-autoimmune thyroid diseases 37 euthyroid controls were consecutively recruited. All...