A5036811574- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
Nanjing University of Chinese Medicine
2022-2023
Jiangsu Provincial Academy of Traditional Chinese Medicine
2023
Myocardial ischemia/reperfusion injury (MIRI) is related to ferroptosis and apoptosis elicited by reactive oxygen species (ROS). In this research, we investigated the protective effect of salvianolic acid B (SAB) as a natural antioxidant on in MIRI process, discussed mechanism inhibiting ubiquitin-proteasome degradation glutathione peroxidase 4 (GPX4) c-Jun N-terminal kinases (JNK) signal pathway. We observed that occurred rat model vivo H9c2 cardiomyocyte hypoxia/reoxygenation (H/R) damage...
Abstract Vascular endothelial cells (VECs) are located between the blood plasma and vascular tissue, ferroptosis (iron‐dependent programmed cell death) of VECs can lead to a range cardiovascular diseases. Icariin is main active ingredient Epimedium brevicornum Maxim., which improve dysfunction. In present study, protective effects icariin on oxidised low‐density lipoprotein (ox‐LDL)‐treated high‐fat diet‐fed Apolipoprotein E‐deficient mice were investigated. Inflammatory fibrosis in tissues...
Myocardial fibrosis leads to cardiac remodeling and dysfunction. Curcumae Rhizoma has been utilized in clinical trials treat a variety of cardiovascular illnesses, although its role myocardial is unknown.The purpose current study was explore the potential mechanism action anti-myocardial effects treatment with Rhizoma.The chemical components aqueous extract from were identified using GC-MS analysis. A prediction network describing relationship between MF established based on information...