A5101438668- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Cancer therapeutics and mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Nanoparticle-Based Drug Delivery
- Environmental Quality and Pollution
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Phytochemistry and biological activities of Ficus species
- Inflammasome and immune disorders
- Heavy Metals in Plants
- Traditional Chinese Medicine Analysis
- Plant and animal studies
- Neurotransmitter Receptor Influence on Behavior
- Advanced Glycation End Products research
- Synthesis and biological activity
- Fermentation and Sensory Analysis
- DNA and Nucleic Acid Chemistry
- Parkinson's Disease Mechanisms and Treatments
- Catalytic C–H Functionalization Methods
- Immune Response and Inflammation
Southwest Forestry University
2024-2025
Huadong Hospital
2022-2025
Shanghai Jiao Tong University
2025
Jining First People's Hospital
2025
Fudan University
2022-2025
Shanghai Sixth People's Hospital
2025
Sichuan University
2012-2024
University of South China
2022-2024
Second Affiliated Hospital of Zhejiang University
2021-2024
Guiyang Medical University
2021-2023
A mitochondria-targeting nanosystem, BP@PDA–Ce6&TPP NSs, has been constructed, and exhibit excellent performance in imaging-guided synergistic photothermal photodynamic cancer therapy.
Abstract Background Sepsis is a critical disease associated with extremely high mortality. Some severe forms of sepsis can induce brain injury, thus causing behavioral and cognitive dysfunction. Pyroptosis type cell death that differs from apoptosis plays an important role in the occurrence development infectious diseases, nervous system-related diseases. A recent study has found there pyroptosis hippocampus sepsis-induced but its mechanism treatment scheme have not been evaluated. Methods...
The accumulation of abnormal aggregation amyloid-β plaques is one the most distinguishing pathologies Alzheimer's disease (AD) and highly toxic to neurons. Exosomes have demonstrated great potential for AD therapy. However, impact underlying mechanism M2 microglia-derived exosomes (M2-EXOs) in progression outcome are seldom explored. Therefore, we employed an Aβ1-42 oligomer (Aβ)-induced model neuronal HT-22 cells 7-month-old APP/PS1 mice investigate effects M2-EXOs on AD. We revealed that...
Oxidative rearrangement of 3-substituted indoles is a fundamental organic transformation for the synthesis 2-oxindole scaffolds. However, this time-consuming and complex task produces single type product via two-electron oxidation using stoichiometric chemical oxidants. Herein, we report unified efficient copper-catalyzed selective single-electron transfer strategy three reactions air (O2) as terminal oxidant, providing streamlined practical synthetic approach to access 3-hydroxyl-,...
Osteoinduction and proliferation of bone-marrow stromal cells (BMSCs) in three-dimensional (3D) poly(ε-caprolactone) (PCL) scaffolds have not been studied throughly are technically challenging. This study aimed to optimize nanocomposites 3D PCL provide superior adhesion, differentiation environment for BMSCs this scenario.BMSCs were isolated cultured a novel tissue culture scaffold coated with poly-lysine, hydroxyapatite (HAp), collagen HAp/collagen. Cell morphology was observed BMSC...
We performed studies to determine the role of high-mobility group box 1 (HMGB1) in cigarette smoke (CS)–induced pulmonary inflammation. After mice were exposed five cigarettes four times a day for 3 d, toll-like receptor 4 (TLR4) expression and TLR4-mediated signaling significantly up-regulated, HMGB1 had translocated from nucleus cytoplasm lung epithelial cells then been released into extracellular space. On CS exposure, inflammatory cell recruitment proinflammatory cytokine production...
Introduction Diabetes is a risk factor for Parkinson's disease (PD) and shares similar dysregulated insulin pathways. Glucagon-like peptide-1 (GLP-1) analogs originally designed to treat diabetes have shown potent neuroprotective activity in preclinical studies of PD. They are by inhibiting inflammation, improving neuronal survival, maintenance synapses, dopaminergic transmission the brain. Building on this, three clinical reported impressive effects patients with PD, testing exendin-4...
Magnetic gold nanoparticles (mGNPs) with uniform size and morphology synthesized by our sonication treatment method were covalently bound fluorescein isothiocyanate (FITC) molecules. Driven an external magnetic field, FITC-labelled delivered into plant cells without cell walls, evident from sectional transmission electron microscopy images. Confocal images further indicate that the green fluorescence in canola protoplasts walled indeed came FITC molecules, instead of chloroplasts’...
// Wei Liu 1 , Yuan-Hao Wu 1, 2 Lei Zhang Bin Xue Yi Wang Xiao-Ya Fang Zuo Xiao-Yan Yang Fu-Yu Chen Ran Duan Yue Cai Bo and Ji 3 Department of Rheumatology Immunology, First Teaching Hospital Tianjin University Traditional Chinese Medicine, 300193, China Institute Basic Research in Clinical Academy Medical Sciences, Beijing 100700, The 272nd People's Liberation Army, 300020, Correspondence to: Wu, email: doctor.wuyh@gmail.com Keywords: microRNA-146a; proinflammatory cytokine; fibroblast-like...
Abstract Background Excessive extracellular matrix (ECM) deposition in pancreatic ductal adenocarcinoma (PDAC) severely limits therapeutic drug penetration into tumors and is associated with poor prognosis. Collagen the most abundant protein tumor ECM, which main obstacle that hinders diffusion of chemotherapeutic drugs or nanomedicines. Methods We designed a collagenase-functionalized biomimetic drug-loaded Au nanoplatform combined ECM degradation, active targeting, immune evasion,...
The fig (the syconium of the Ficus tree) and its pollinating wasp represent exceptional examples for researching plant–insect interactions due to their remarkable specificity in species interaction mutually beneficial symbiotic relationship. However, mechanisms underlying developmental process monoecious figs response entry wasps (pollinators) metabolic changes occurring during this remain elusive. Our study employed a combination controlled experiments field LC-MS methods investigate impact...
Ficus trees (Moraceae) play a vital role in sustaining the stability of tropical and subtropical rainforests. The obligate mutualism between species their pollinating fig wasps renders them an exemplary model for investigating insect–plant coevolution. In this study, we employed hispida Linn. f., ecologically significant rainforests, to conduct wasp-introduction controlled experiment field. This method enabled us precisely delineate developmental stages figs. We collected samples at specific...
： Introduction: Many reports indicate that the occurrence of multiple myeloma (MM) is closely related to inflammation and immunity. Although survival rates have been gradually improving in recent years, cure rate still not optimistic enough. Therefore, it necessary continue exploring causes MM. Method: This study utilizes Mendelian randomization (MR) analysis establish connection between inflammatory factors, immune cells, Results: In studies, a significant correlation was observed...
Abstract Vascular dementia (VaD) is a syndrome of cognitive dysfunction caused by cerebrovascular damage. At present, VaD mainly prevented controlling vascular risk factors clinically, while there has been limited progress in therapies directly targeting its pathological mechanism. Mitochondrial plays key role the pathogenesis VaD, but are no drugs to improve regulating mitochondrial function clinical practice. In this study, semaglutide was used as an intervention therapy and results showed...
A series of novel teraryl oxazolidinone compounds was designed, synthesized, and evaluated for their antimicrobial activity toxicities. The with aromatic N-heterocyclic substituents at the 4-position pyrazolyl ring showed better antibacterial against tested bacteria than other different patterns substitution. Among all potent compounds, 10f exhibited promising safety profile in MTT assays hERG K+ channel inhibition test. Furthermore, its phosphate found to be highly soluble water (47.1...
The efficacy of immune checkpoint blockade (ICB), in the treatment hepatocellular carcinoma (HCC), is limited due to low levels tumor-infiltrating T lymphocytes and deficient this immunologically "cool" tumor. Thus, combination approaches are needed increase response rates ICB induce synergistic antitumor immunity.Herein, we designed a pH-sensitive multifunctional nanoplatform based on layered double hydroxides (LDHs) loaded with siRNA block intracellular NR2F6, together asynchronous surface...