A5100332837- Traumatic Brain Injury and Neurovascular Disturbances
- Dental Radiography and Imaging
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Dental Implant Techniques and Outcomes
- Tryptophan and brain disorders
- Genetic Mapping and Diversity in Plants and Animals
- S100 Proteins and Annexins
- Neurogenesis and neuroplasticity mechanisms
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Oral microbiology and periodontitis research
- Traumatic Brain Injury Research
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Temporomandibular Joint Disorders
- Ferroptosis and cancer prognosis
Xi'an Jiaotong University
2021-2025
Indiana University – Purdue University Indianapolis
2009-2025
University of Indianapolis
2025
Jiangxi University of Traditional Chinese Medicine
2024-2025
Massachusetts General Hospital
2018-2024
Harvard University
2018-2024
Capital Medical University
2019-2024
Shanghai Jiao Tong University
2010-2024
University of South China
2024
Chongqing Medical University
2021-2024
Abstract Traumatic brain injury (TBI) is a universal leading cause of long-term neurological disability and causes huge burden to an ever-growing population. Moderate intensity treadmill exercise has been recognized as efficient intervention combat TBI-induced motor cognitive disorders, yet the underlying mechanism still unclear. Ferroptosis known be highly implicated in TBI pathophysiology, anti-ferroptosis effects have reported other diseases except for TBI. In addition cytokine induction,...
Idiopathic rapid eye movement sleep behavior disorder is an early sign of neurodegenerative disease. This study aimed to quantitatively evaluate iron content in idiopathic patients using quantitative susceptibility mapping and examine the potential this technique identify prodromal stage α-synucleinopathies.Twenty-five patients, 32 Parkinson's disease 50 healthy controls underwent mapping. The mean magnetic values within bilateral substantia nigra, globus pallidus, red nucleus, head caudate...
Abstract Emerging evidence shows that targeting ferroptosis may be a potential therapeutic strategy for treating traumatic brain injury (TBI). Hydrogen sulfide (H 2 S) has been proven to play neuroprotective role in TBI, but little is known about the effects of H S on TBI-induced ferroptosis. In addition, it reported Wnt signaling pathway can also actively regulate However, whether inhibits via after TBI remains unclear. this study, we first found addition alleviating neuronal damage and...
Abstract Lysine demethylase 7A (KDM7A) catalyzes the removal of dimethylation from histone H3 lysine 9 and 27, both which are associated with transcription repression. Previous study indicates that Kdm7a mRNA in medial prefrontal cortex (mPFC) increases after drug exposure, yet its role drug‐related behaviors is largely unknown. In a morphine‐conditioned place preference (CPP) paradigm, these findings reveal specific increase expression mPFC 7 days withdrawal. Subsequently, results...
The rising prevalence of Alzheimer's disease (AD) underscores the urgent need for novel therapeutic agents derived from natural sources. Among flavonoids, 3',4',5,7-tetramethoxyflavone (TMF), a structural analog luteolin, has gained attention its favorable pharmacokinetics and potential neuroprotective properties. Despite significant effects TMF, efficacy mechanism action in AD remain unclear. This study explored TMF's pharmacological models, highlighting ability to improve memory cognitive...
Significance In patients with progressive vestibular schwannoma (VS), radiotherapy is associated the risk of debilitating hearing loss. There an urgent need to identify adjunct therapy that, by enhancing efficacy radiation, can help lower radiation dose and preserve hearing. our newly developed cerebellopontine angle model schwannomas that faithfully recapitulates tumor-induced loss, we demonstrate cMET blockade sensitizes (RT) in neurofibromatosis type II animal models without any adverse...
Gray leaf spot (GLS), caused by the fungal pathogen Cercospora zeina (C. zeina), is one of most destructive soil-borne diseases in maize (Zea mays L.), and severely reduces production Southwest China. However, mechanism resistance to GLS not clear few resistant alleles have been identified. Two inbred lines, which were shown be (R6) susceptible (S8) GLS, injected C. spore suspensions. Transcriptome analysis was carried out with tissue at 0, 6, 24, 144, 240 h after inoculation. Compared 0...
Drug transmission through the blood-brain barrier (BBB) is considered an arduous challenge for brain injury treatment following return of spontaneous circulation after cardiac arrest (CA-ROSC). Inspired by propensity melanoma metastasis to brain, B16F10 cell membranes are camouflaged on 2-methoxyestradiol (2ME2)-loaded reactive oxygen species (ROS)-triggered "Padlock" nanoparticles that constructed phenylboronic acid pinacol esters conjugated D-a-tocopheryl polyethylene glycol succinate...
Abstract Hu'po Anshen decoction (HPASD), a traditional Chinese medicine used to treat concussion and fracture, could regulate the expression of bone morphogenetic protein 2 (BMP2). However, whether HPASD affects fracture healing traumatic brain injury (TBI) combined with through BMP2 its downstream signals remains obscure. The chondrocyte‐specific conditional knockout mice cyclooxygenase‐2 (COX2) overexpression were generated. treated surgery, TBI, or TBI followed by different doses (2.4,...
Neurofilament light chain (NF-L) plays critical roles in synapses that are relevant to neuropsychiatric diseases. Despite postmortem evidence NF-L is decreased opiate abusers, its role and underlying mechanisms remain largely unknown. We found the microinjection of histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) into ventrolateral orbital cortex (VLO) attenuated chronic morphine-induced behavioral sensitization. The TSA blocked decrease NF-L. However, our chromatin...