A5069405019- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Biochemical and Structural Characterization
- Inflammation biomarkers and pathways
- Barrier Structure and Function Studies
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Immune Response and Inflammation
- Berberine and alkaloids research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Flavonoids in Medical Research
- Antimicrobial Peptides and Activities
Nanjing University of Chinese Medicine
2016-2024
Queen's University Belfast
2018
Abstract Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized by recurrent eczematous lesions. Interleukin (IL)−33, cytokine of the IL-1 family, was found to play an important role in pathogenesis AD. As key component inflammasome, NLRP3 has been mostly described myeloid cells that mediate inflammasome activation conducted proinflammatory production family. However, AD, as well IL-33 processing are highly controversial. Whether can expression and...
Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is pivotal pathological feature of asthma. The relationship between claudin1 expression EGFR still poorly understood. In this report, we showed that correlated with asthma stage, both patients house dust mite (HDM)-induced mouse model. knockdown MUC5AC overexpression 16HBE cells airways. addition, negatively severity as demonstrated...
Objective Bile reflux plays a key role in the development of gastric intestinal metaplasia (GIM), an independent risk factor cancer. Here, we aimed to explore biological mechanism GIM induced by bile rat model. Methods Rats were treated with 2% sodium salicylate and allowed freely drink 20 mmol/L deoxycholate for 12 weeks, was confirmed histopathological analysis. Gastric microbiota profiled according 16S rDNA V3–V4 region, transcriptome sequenced, serum acids (BAs) analyzed targeted...
Abstract Allergic asthma is a common chronic lung inflammatory disease and seriously influences public health. We aim to investigate the effects of formononetin (FMN) calycosin (CAL), 2 flavonoids in Radix Astragali, on allergic elucidate possible therapeutic targets. A house dust mite (HDM)-induced mouse model TNF-α Poly(I:C) co-stimulated human bronchial epithelial cell line (16HBE) were performed respectively vivo vitro. The role G protein-coupled estrogen receptor (GPER) was explored by...
Background: Currently no specific treatments are available for sepsis and the associated syndromes including acute lung injury (ALI). Jinhong Decoction (JHD) is a traditional Chinese prescription, it has been applied clinically as an efficient safe treatment sepsis, but underlying mechanism remains unknown. The aim of study was to explore potential mechanisms JHD ameliorating concurrent ALI. Methods: cecum ligation puncture (CLP)- induced murine model established determining efficacy...
Public health is confronting the threat caused by antibiotic resistance and this means new antibacterial strategies must be developed urgently. Antimicrobial peptides (AMPs) have been considered as promising therapeutic candidates against infection in post-antibiotic era. In paper, we dismissed significance of "Rana box" natural nigrocin-HL identified from skin secretion Hylarana latouchii comparing its activity with nigrocin-HLD without motif. By substituting sequence an amidated...
Atopic dermatitis (AD) is a prevalent inflammatory skin disease characterized by its chronic nature and relapse. Ample evidence suggests that non-coding RNAs play major role in AD pathogenesis. However, the mechanism remains unknown, particularly recurrence. Dynamic morphological cytokine changes were measured throughout whole course of an FITC-induced recurrence murine model. Microarray assay integrative analysis performed to comprehensively explore long RNA (lncRNA), messenger (mRNA),...
Pudilan antiphlogistic oral liquid (PDL) is a commercial traditional Chinese medicine widely used in the treatment of variety inflammatory diseases. However, specific mechanisms PDL's anti-inflammatory effects have not been fully understood. In this research, five classic models and network pharmacology-based strategy were utilized to evaluate its efficacy elucidate multicomponent multitarget mode mechanism. A systems pharmacology approach was carried out via holistic process active compound...
Abstract To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model allergic contact dermatitis (ACD). AS-IV administered sensitization phase, rather than elicitation dramatically alleviated symptoms inflammation. We hypothesized that exerts by regulating production key pro-allergic cytokines based on fact interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) levels increase significantly initial stage phase. ACD inhibited TSLP IL-33...
Clinically, the treatments against asthma like β2 agonist focus on controlling symptoms rather than inhibiting recurrence radically. This study aims to evaluate efficacy and mechanism of a potent Chinese prescription Yu-Ping-Feng-San (YPFS) recurrence. We here established an optimized house dust mite (HDM)-induced mice model with typical asthmatic responses such as significantly augmented airway hyperresponsiveness (AHR), elevated serum IgE, pulmonary type 2 cytokines IL-5 IL-13 levels,...
Background: Recent works imply that immune memory might be expanded to group 2 innate lymphoid cells (ILC2s), but the cellular and molecular bases are largely unknown. Here, we investigated migrating properties of Lin KLRG1 IL-17RB ILC2s (herein referred as mILC2s) their contribution asthma relapse. Methods: Clinical asthmatic subjects HDM-induced mice models were applied investigate memory-like characteristics mILC2s including greater effector cytokine-producing potential in vivo...