A5075141324- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Urticaria and Related Conditions
- Inflammatory Bowel Disease
- Immune cells in cancer
- Liver Disease and Transplantation
- Glycosylation and Glycoproteins Research
- Psoriasis: Treatment and Pathogenesis
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Antifungal resistance and susceptibility
- Pain Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
- Immunodeficiency and Autoimmune Disorders
- Spinal Cord Injury Research
- Diet and metabolism studies
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Studies
Lishui Central Hospital
2025
Wenzhou Medical University
2025
Harbin Medical University
2023-2025
Fourth Affiliated Hospital of Harbin Medical University
2023-2025
Nanjing University of Chinese Medicine
2015-2024
Institute of Subtropical Agriculture
2021-2023
University of Chinese Academy of Sciences
2021-2023
Anhui Medical University
2022-2023
Union Hospital
2023
Fujian Medical University
2023
Signal transducer and activator of transcription 3 (STAT3) triggered production Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark chronic mucocutaneous candidiasis (CMC). In patients with autosomal dominant CMC, we others previously reported defective Th17 responses underlying gain-of-function (GOF) STAT1 mutations, but how this affects STAT3...
We determine if LBP contributes to the recovery from spermatogenic dysfunction in diabetic individuals.
Abstract Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized by recurrent eczematous lesions. Interleukin (IL)−33, cytokine of the IL-1 family, was found to play an important role in pathogenesis AD. As key component inflammasome, NLRP3 has been mostly described myeloid cells that mediate inflammasome activation conducted proinflammatory production family. However, AD, as well IL-33 processing are highly controversial. Whether can expression and...
<b><i>Background:</i></b> Recent data suggest that major depression is potentially associated with dysregulated cytokine production. However, the roles of T helper (Th) cells and their subsets in development still remain to be determined. The present study assessed changes Th cell cytokines during a mouse model. <b><i>Methods:</i></b> Chronic unpredictable mild stress (CUMS) was used simulate behavior mice. open field test, sucrose preference,...
Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is pivotal pathological feature of asthma. The relationship between claudin1 expression EGFR still poorly understood. In this report, we showed that correlated with asthma stage, both patients house dust mite (HDM)-induced mouse model. knockdown MUC5AC overexpression 16HBE cells airways. addition, negatively severity as demonstrated...
Chronic heat stress (HS) induces oxidative damage, low immunity, and intestinal flora disturbance of fish, posing great challenges to the aquaculture industry. As an important plant extract, mulberry leaf extract (MLE) has been shown have antioxidant immune-boosting properties. This study evaluated protective effect dietary MLE on HS-induced liver injury in Largemouth bass ( Micropterus salmoides ) based damage parameters, immune composition. Fish were randomly assigned into three groups:...
Background Canopy FGF signalling regulator 3 (CNPY3) is involved in immune regulation, tumorigenesis and development, nevertheless, its role glioma remains largely unexplored. Our study aimed to explore the regulatory of CNPY3 as a prognostic biomarker human cell migration, invasion infiltration. Methods Bioinformatics analysis clinical relevance public databases was performed. COX regression performed assess relationship between prognosis. GO Kyoto Encyclopedia Genes Genomes analyses were...
Background & Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation Th17-dependent responses warrants further study. Inhibition retinoic acid-related orphan receptor gamma (RORɣt), master regulator Th17 signature, is currently being explored inflammatory diseases. Our aim was to determine effect a novel oral RORɣt antagonist (BI119) human CD and on an experimental model intestinal inflammation. Methods: 51 patients 11 healthy subjects were...
Spinal cord injury (SCI) is a devastating condition affecting hundreds of thousands people worldwide annually. SCI results in activation the inflammatory response and apoptosis, generates oxidative stress, which has deleterious effects on recovery motor function. Apocynin, an inhibitor NADPH oxidase, been demonstrated to improve neuronal functional rat models SCI. However, efficacy apocynin treatment post-SCI not investigated. The aim this study was observe repair acute spinal damage rats...
This study investigated the anti-inflammatory and analgesic activities of indigo in mice explored possible related mechanisms.
Atopic march refers to the phenomenon wherein occurrence of asthma and food allergy tends increase after atopic dermatitis. The mechanism underlying progression allergic inflammation from skin gastrointestinal (GI) tract airways has still remained elusive. Impaired barrier was proposed as a risk factor for sensitization. Claudin-1 protein forms tight junctions is highly expressed in epithelium skin, airways, GI tract, thus, downregulation claudin-1 expression level caused by CLDN-1 gene...
Abstract Allergic asthma is a common chronic lung inflammatory disease and seriously influences public health. We aim to investigate the effects of formononetin (FMN) calycosin (CAL), 2 flavonoids in Radix Astragali, on allergic elucidate possible therapeutic targets. A house dust mite (HDM)-induced mouse model TNF-α Poly(I:C) co-stimulated human bronchial epithelial cell line (16HBE) were performed respectively vivo vitro. The role G protein-coupled estrogen receptor (GPER) was explored by...
The purpose of this study was to investigate the possible protective effect N-acetylserotonin (NAS) against acute hepatic ischemia-reperfusion (I/R) injury in mice. Adult male mice were randomly divided into three groups: sham, I/R, and I/R + NAS. model generated by clamping artery, portal vein, common bile duct with a microvascular bulldog clamp for 30 min, then removing allowing reperfusion 6 h. Morphologic changes hepatocyte apoptosis evaluated hematoxylin-eosin (HE) terminal...