A5042597790- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Polyomavirus and related diseases
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Ferroptosis and cancer prognosis
- Cancer therapeutics and mechanisms
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Reservoir Engineering and Simulation Methods
- Cell death mechanisms and regulation
First Affiliated Hospital of Xinjiang Medical University
2016-2025
Xinjiang Medical University
2016-2025
Peking University Shenzhen Hospital
2021-2024
China Shenhua Energy (China)
2024
Beijing Hospital of Traditional Chinese Medicine
2014-2022
Hong Kong University of Science and Technology
2022
University of Hong Kong - Shenzhen Hospital
2022
Dalian Medical University
2011-2021
National University of Singapore
2018-2021
Shenzhen University
2021
The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability such regime. Here we report evidence enhanced reliance on mitochondrial oxidative phosphorylation (OXPHOS) in cancers manifesting therapies. To that effect, describe novel OXPHOS targeting activity small molecule compound, OPB-51602 (OPB). Of note, priori with...
Tim-3 is a negative immunoregulator in anti-tumor response, but its mechanism chronic lymphocytic leukemia (CLL) not yet clear. The aim of this study was to understand the role Galectin-9/Tim-3 signaling pathway regulation CD4+ T cell subsets CLL patients. Flow cytometry results showed that number Treg cells obviously increased, and there significant Treg/Th17 imbalance In addition, overexpressed on surface Th1 levels Galectin-9 IL-10 were significantly elevated patients CLL, especially...
NIMA-related kinase 7 (NEK7) is a serine/threonine involved in cell cycle progression via mitotic spindle formation and cytokinesis. It has been related to multiple cancers, including breast cancer, hepatocellular lung colorectal cancer. Moreover, NEK7 regulated the NLRP3 inflammasome activate Caspase-1, resulting pyroptosis. In present study, we investigated whether pyroptosis of carcinoma (HCC). Interestingly, found that was significantly expression marker GSDMD HCC. We correlated with...
Abstract Digital core technology is emerging as a transformative force in the realm of reservoir engineering, offering unprecedented capabilities for conducting detailed and non-destructive analyses experiments that were previously unimaginable. Traditional approaches to constructing digital cores, such physical numerical reconstruction, have inherent limitations terms cost, time, resource utilization. To overcome these obstacles, groundbreaking intelligent construction method called...
To investigate the expression of co-inhibitory molecules TIGIT/CD155 and PD-1 on CD4+T cells Treg in peripheral blood patients with chronic lymphocytic leukemia (CLL) analyze their clinical significance. The TIGIT was detected by flow cytometry 40 CLL 20 healthy controls. Additionally, CD155 B DC enrolled subjects detected. proportions PD-1+TIGIT+CD4+T cells, PD-1+TIGIT+Treg CD155+DC were significantly higher than those controls ( P < 0.05). PD-1+TIGIT-CD4+T PD-1+TIGIT-Treg respectively Both...
The gut microbiome is essential for human health due to its effects on disease development, drug metabolism and the immune system. It may also play a role in interaction with environmental toxicants. However, effect of epoxiconazole, fungicide active ingredient from class azoles developed protect crops, abundance composition has never been studied. We put forward hypothesis that changes microbiota be early signs toxicity induced by epoxiconazole.In this study, female rats were fed...
Abstract Bcl-2 phosphorylation at serine-70 (S70pBcl2) confers resistance against drug-induced apoptosis. Nevertheless, its specific mechanism in driving drug-resistance remains unclear. We present evidence that S70pBcl2 promotes cancer cell survival by acting as a redox sensor and modulator to prevent oxidative stress-induced DNA damage execution. Increased levels are inversely correlated with chronic lymphocytic leukemia (CLL) lymphoma patient-derived primary cells well reactive oxygen...
MicroRNAs (miRNAs) and aberrant glycosylation both play important roles in tumor metastasis. In this study, the role of miR-23a N-glycosylation metastasis mouse hepatocellular carcinoma (HCC) cells was investigated. The miRNA expression array profiles that were confirmed by qPCR Western blot analyses revealed higher levels Hca-P (with lymphatic potential) than Hepa1-6 no potential), while mannoside acetylglucosaminyltransferase 3 (Mgat3) negatively associated with potential. Mgat3 is a key...
Pancreatic adenocarcinoma (PAAD) is an aggressive malignancy, with a major mortality resulting from the rapid progression of metastasis. Unfortunately, no effective treatment strategy has been developed for PAAD metastasis to date. Thus, unraveling mechanisms involved in metastatic phenotype may facilitate patients. PIK3CB oncogene implicated cancer development and but less known about whether participates Therefore, objective this study explore mechanism(s) In our study, we examined...
Rationale: Pancreatic cancer is one of the most difficult cancers to manage and its poor prognosis stems from lack a reliable early disease biomarker coupled with highly metastatic potential. Liver metastasis accounts for high mortality rate in pancreatic cancer. Therefore, better understanding mechanism(s) underlying acquisition potential desirable. Methods: Microarray analysis wild-type liver human cell lines was performed identify gene expression signatures that underlie process. We...
The prognosis for pancreatic ductal adenocarcinoma (PDAC) patients is still dismal. Elucidation of associated genomic alteration may provide effective therapeutic strategies PDAC treatment. NIMA-related protein kinase 7 widely expressed in various tumors, including breast cancer, colorectal cancer and lung promotes the proliferation liver cells vitro vivo . We investigated expression level NEK7 tumor tissues adjacent normal using immunohistochemistry 90 with PADC. Meanwhile, RNA was examined...
Previous evidence have demonstrated that p21-activated kinase PAK4 was correlated with breast cancer. The aim of this paper is to study the expression and interaction (pAK)-4 P54 protein in cancer.A total 80 patients were enrolled our (breast fibroma n = 20, noninvasive cancer early invasive advanced cancer). detected by immunohistochemical S-P method, relationship between them different pathological characteristics compared. subcellular localization vitro observed immunofluorescence...
Galectin-9 and myeloid-derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values chronic lymphocytic leukemia (CLL) not been fully elucidated. This study aimed to analyze the prognosis of MDSCs CLL. The concentrations Galectin-9, argininase-1, inducible nitric oxide synthase serum were detected by enzyme-linked immune sorbent assay. expression Tim-3 protein peripheral blood mononuclear cell was Western blot. Flow cytometry used percentages on T-cells (CD3+...
The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, regulation of Tim-3/Galectin-9 CD4 cell subsets in multiple myeloma (MM) remains unclear. aim this study was to investigate relationship by pathway clinical prognostic indicators MM. were detected flow cytometry, PCR ELISA 60 MM patients 40 healthy controls, correlation with parameters analyzed. expressions cells, mRNA PBMC level protein serum significantly elevated...
The death inhibitory proteins, cFLIP and Bcl-2, canonically act at different steps to regulate receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic means effect an increase intracellular superoxide result upregulation. Interestingly, Bcl-2 overexpression is associated with a concomitant cFLIP, reducing sensitizes overexpressing cells via downregulation of cFLIP. Moreover, inhibiting glycolytic flux overcomes resistance by superoxide-dependent...
Nonalcoholic fatty liver disease (NAFLD) is the most common metabolic globally, and incidence of NAFLD has been increasing rapidly year by year. Currently, there no effective pharmacotherapy for NAFLD. Therefore, studies are urgently needed to explore therapeutic drugs In this study, we show that isoschaftoside (ISO) dramatically reduces lipid deposition in cells. Meanwhile, ISO treatment reverses hepatic steatosis mice. Importantly, reveal suppresses expression light-chain 3-II (LC3-II)...
Abstract Relative permeability (RP) curves which provide fundamental insights into porous media flow behavior serve as critical parameters in reservoir engineering and numerical simulation studies. However, obtaining accurate RP remains a challenge due to expensive experimental costs, core contamination, measurement errors, other factors. To address this issue, an innovative approach using deep learning strategy is proposed for the prediction of rock sample directly from mercury injection...
Multi-objective optimization algorithms are crucial for addressing real-world problems, particularly with regard to optimizing well control parameters, which often computationally expensive due their reliance on numerical simulations. Surrogate-assisted models help reduce this computational burden, but effectiveness depends the quality of surrogates, can be affected by candidate dimension and noise. This study proposes a novel surrogate-assisted multi-objective framework (MOO-SESA) that...