A5053569612- Microscopic Colitis
- Cancer, Hypoxia, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Liver physiology and pathology
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Heat shock proteins research
- Cancer Immunotherapy and Biomarkers
Zhengzhou University
2022
High mobility group protein 1 (HMGB1) is a highly conserved DNA-binding nuclear that participates in the occurrence and development of silicosis. HMGB1 binds to its specific receptor activates phosphatidylinositol 3-kinase (PI3K)/protein kinase B, (PKB; Akt)/mammalian target rapamycin (mTOR) pathway. Brahma-related genes (BRG1; SMARCA4) core subunit SWI/SNF. Akt pathway through BRG1 promote proliferation prostate cancer. Glycyrrhizic acid new pharmacological inhibitor HMGB1, which may...
Background: Excessive accumulation of extracellular matrix is a key feature pulmonary fibrosis (PF), and myofibroblasts are the main producers matrix. Fibroblasts major source myofibroblasts, but mechanisms transdifferentiation unclear. Methods: In vitro, transforming growth factor-β1 was used to induce NIH-3T3 cell transdifferentiation. DMOG increase hypoxia-inducible factor-1α subunit (HIF-1α) expression. KC7F2 siRNA decreased HIF-1α vivo, silica particles were PF in C57BL/6N mice, reduce...
The purpose of this study was to investigate the expression immune checkpoint cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T cell immunoglobulin mucin domain 3 (TIM-3) in peripheral blood lymphocytes medical radiologists. incorporated 100 male radiologists 107 healthy controls. expressions CTLA-4 TIM-3 among CD4+ CD8+ were detected by flow cytometry. levels CD4+T cells radiation workers lower than those controls (p < 0.05). Correlation analysis showed that CD8+CTLA-4 level...