A5102951063- Gut microbiota and health
- Corporate Finance and Governance
- Financial Markets and Investment Strategies
- Clostridium difficile and Clostridium perfringens research
- Job Satisfaction and Organizational Behavior
- Metabolomics and Mass Spectrometry Studies
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Corporate Social Responsibility Reporting
- Culture, Economy, and Development Studies
- International Business and FDI
- Phytochemical Studies and Bioactivities
- Environmental Sustainability in Business
- Traditional Chinese Medicine Analysis
- Power Systems and Renewable Energy
- Firm Innovation and Growth
- Plant Gene Expression Analysis
- Botulinum Toxin and Related Neurological Disorders
- Innovation and Knowledge Management
- Cancer Immunotherapy and Biomarkers
- Plant biochemistry and biosynthesis
- Auditing, Earnings Management, Governance
- Advancements in Transdermal Drug Delivery
- Healthcare Systems and Reforms
Capital Medical University
2009-2025
Beijing Chao-Yang Hospital
2019-2025
Hainan General Hospital
2017-2025
Chinese PLA General Hospital
2017-2025
Economic Research Institute
2025
London School of Economics and Political Science
2025
Beijing University of Chemical Technology
2023-2024
Tsinghua University
2013-2024
Jiangnan University
2024
Wuxi Fourth People's Hospital
2024
Abstract The constant emergence of SARS-CoV-2 variants continues to impair the efficacy existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved epitope targeted by broad-spectrum antibody BA7535, demonstrates high neutralization potency against not only previous variants, such as Alpha, Beta, Gamma, Delta Omicron BA.1-BA.5, but also more recently emerged subvariants, including BF.7, CH.1.1, XBB.1,...
Olfactory dysfunction, one of the earliest non-motor symptoms Parkinson disease (PD), is accompanied by abnormal deposition SNCA/α-synuclein in olfactory bulb (OB). The macroautophagy/autophagy-lysosome pathway (ALP) plays an important role degrading pathological SNCA and modulating this may be a promising treatment strategy. P2RX4 (purinergic receptor P2X, ligand-gated ion channel 4), member purinergic X family, key molecule regulating ALP. Piperine (PIP) Chinese medicine with...
Blind and excessive application of fertilizers was found during the cultivation Panax notoginseng in fields, as well increase root rot disease incidence.Both "3414" orthogonal test designs were performed at Shilin county, Yunnan province, China, for NPK (nitrogen, phosphorus, potassium) mineral fertilizers, respectively. The data used to construct one-, two-, three-factor quadratic regression models. effect fertilizer deficiency on yield loss also analyzed confirm result predicted by these A...
Dysbiotic gut microbiota (GM) and disordered metabolic patterns are known to be involved in the clinical expression of atrial fibrillation (AF). However, little evidence has been reported characterizing specific changes fecal paroxysmal AF (PAF) persistent (psAF). To provide a comprehensive understanding GM dysbiosis types, we assessed signatures 30 PAF patients, 20 psAF 50 non-AF controls based on metagenomic metabolomic analyses. Compared with control subjects, similar were identified...
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report the isolation and analysis of two anti-RBD neutralizing BA7208 BA7125 mice engineered produce human antibodies. While showed broadly activity against all variants except sublineages, was potently tested (including BA.1-BA.5) Mu. By combining through knobs-into-holes technology,...
Abstract The deployment of distributed photovoltaic technology is paramount importance for developing a novel power system architecture wherein renewable energy constitutes the primary source. This paper investigates construction and operation residential storage in context current step–peak–valley tariff system. Firstly, an introduction to structure photovoltaic–energy associated will be provided. Secondly, minimize investment annual operational maintenance costs system, optimal capacity...
Abstract The employment of multiple AUVs is to perform missions while maintaining a geometric formation designated. In this paper, communication mechanism based on blackboard introduced support cooperation between AUVs, messages are typed according artificial intelligence. hierarchical control algorithm proposed, including designing level, generating behavioural evaluating level. Several patterns designed different tasks and requirements. Orderly‐Quaternion sets matrix defined for the design...
Background The aspartate aminotransferase-to-platelet ratio index (APRI) is an effective non-invasive marker for chronic liver dysfunction. Given that heat stroke patients often suffer from poor prognosis due to multi-organ involvement, with injury and coagulation dysfunction being of particular concern, this study aims investigate whether APRI can comprehensively reflect in explore its relationship 28-day mortality.
Phosphorylation of α -synuclein at serine-129 (p- -syn) is a hallmark Parkinson’s disease (PD) and constitutes nearly 90% α-synuclein in Lewy bodies, playing critical role progression. Despite its pathological significance, the molecular targets mechanisms driving p- -syn-induced toxicity, particularly mitochondrial dysfunction, remain poorly understood. In this study, we observed dysfunction primary cortical neurons derived from mice overexpressing human (h- -syn), which also exhibit...
Abstract Background The gut bacteria-derived metabolite trimethylamine-N-oxide (TMAO) has been discussed in various cardiometabolic diseases. However, evidence characterizing the microbial population responsible for TMAO accumulation patients with atrial fibrillation (AF), an increasingly prevalent arrhythmia, is yet lacking. In order to understand key microorganisms that produce AF, trimethylamine (TMA)-synthesis enzymes and metabolic pathways, as well potential TMA-producers microbiome...
Alternations of gut microbiota (GM) in atrial fibrillation (AF) with elevated diversity, perturbed composition and function have been described previously. The current work aimed to assess the association GM AF recurrence (RAF) after ablation based on metagenomic sequencing metabolomic analyses construct a GM-based predictive model for RAF. Compared non-AF controls (50 individuals), profile were significantly altered between patients recurrent (17 individuals) non-RAF group (23 individuals)....
Chondrichthyes is an important lineage to reconstruct the evolutionary history of vertebrates. Here, we analyzed genome synteny for six chondrichthyan chromosome-level genomes. Our comparative analysis reveals a slow rate chromosomal changes, with infrequent but independent fusions observed in sharks, skates, and chimaeras. The common ancestor had proto-vertebrate-like karyotype, including presence 18 microchromosome pairs. X chromosome conversed shared by all suggesting likely origin sex at...
Menopause is a significant life transition for women, impacting their physical and psychological health. The age at natural menopause (ANM) its associated factors have differed by race region. This study aimed to investigate ANM of early late among Chinese women in Zhejiang province.
The prevalence of chronic kidney disease (CKD) is on the rise, posing a significant public health challenge. Although gut microbiome dysbiosis has been implicated in impairment functions, existence pathological subtypes-linked differences remains largely unknown. We aimed to characterize intestinal microbiota patients with membranous nephropathy (MN), IgA (IgAN), minimal change (MCD), and ischemic renal injury (IRI) order investigate intricate relationship between CKD across different...
Coptis chinensis Franch. is one of the most important medicinal plants globally. However, this species contains relatively high concentrations chromium (Cr) which potentially detrimental to human health. It understand Cr localization and speciation in order evaluate its accumulation transportation mechanisms minimize transfer humans. As little previous work area has been carried out, we utilized synchrotron radiation microscopic X-ray fluorescence (SR-μXRF) laser ablation inductively coupled...
The gibberellin-responsive element binding factor (GRAS) family of proteins plays an important role in the transcriptional regulation plant development and hormone signaling. To date, there are no reports on GRAS expressed Salvia miltiorrhiza. In this study, 28 ESTs that contained domain were identified from a S. miltiorrhiza cDNA library. Of these, full-length sequences five genes cloned sequence analysis indicated all contain only one therefore, belong to family. designated GRAS1-5...
Polygonati rhizoma (PR), a traditional medicinal and edible product with various bioactive components (Polygonatum polysaccharides, saponins, phenols, flavonoids), is widely consumed in China. However, other species morphological characteristics similar to those of the actual are being used replace or adulterate PR, causing issues quality control safety. The similarity PR its substitutes makes classic identification challenging. To address this issue, DNA barcoding-based using ITS2 psbA-trnH...