A5082077288- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- Toxoplasma gondii Research Studies
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- interferon and immune responses
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- SARS-CoV-2 detection and testing
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Effects of Exercise
- Herpesvirus Infections and Treatments
Tianjin Agricultural University
2024
First Affiliated Hospital of Guangzhou Medical University
2023-2024
State Key Laboratory of Respiratory Disease
2023-2024
Guangzhou Medical University
2023-2024
Southern University of Science and Technology
2023
Abstract The constant emergence of SARS-CoV-2 variants continues to impair the efficacy existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved epitope targeted by broad-spectrum antibody BA7535, demonstrates high neutralization potency against not only previous variants, such as Alpha, Beta, Gamma, Delta Omicron BA.1-BA.5, but also more recently emerged subvariants, including BF.7, CH.1.1, XBB.1,...
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report the isolation and analysis of two anti-RBD neutralizing BA7208 BA7125 mice engineered produce human antibodies. While showed broadly activity against all variants except sublineages, was potently tested (including BA.1-BA.5) Mu. By combining through knobs-into-holes technology,...
The ryanodine receptor 2 (RyR2) is essential for cardiac muscle excitation-contraction coupling; dysfunctional RyR2 participates in the development of inherited arrhythmogenic disease. In this study, a novel mutation A690E identified from patient with family inheritance sudden death, and we aimed to investigate pathogenic basis mutation.We generated mouse model that carried mutation. Mice were characterized by adrenergic-induced ventricular arrhythmias similar clinical manifestation patient....