A5003624236- Diabetes Treatment and Management
- Diabetes Management and Research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Adrenal and Paraganglionic Tumors
- Circular RNAs in diseases
- Diabetes and associated disorders
- Polyamine Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Chronic Kidney Disease and Diabetes
- Colorectal Cancer Treatments and Studies
- Autophagy in Disease and Therapy
- Renal Diseases and Glomerulopathies
- Legionella and Acanthamoeba research
- Genetic factors in colorectal cancer
- Protease and Inhibitor Mechanisms
- Traditional Chinese Medicine Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nanoparticles: synthesis and applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Mosquito-borne diseases and control
Nantong University
2010-2025
Taizhou People's Hospital
2010-2025
Nanjing Medical University
2023-2025
Southeast University
2024
Guangzhou Medical University
2023
Northern Jiangsu People's Hospital
2021
Linkou Chang Gung Memorial Hospital
2020
Memorial University of Newfoundland
2014
In the present study, function of microRNA (miR)-214 on diabetic nephropathy (DN) and diabetes proximal tubular cells was investigated. Reverse transcription-quantitative polymerase chain reaction used measure expression miR-214 in rats with DN ELISA performed to oxidative stress ROS levels. Results indicated that peripheral blood significantly decreased DN. The vitro model upregulation reactive oxygen species (ROS) levels, but increased uncoupling protein 2 (UCP2), phosphorylated (p)-Akt...
Pheochromocytoma is a rare catecholamine-secreting tumor that can present with severe hypertensive episodes and other symptoms due to excessive catecholamine release. Approximately 30% of pheochromocytomas are associated hereditary syndromes, including multiple endocrine neoplasia type 2A (MEN2A), an autosomal dominant disorder caused by mutations in the RET proto-oncogene. MEN2A characterized presence medullary thyroid carcinoma, pheochromocytoma, primary hyperparathyroidism. We report case...
Diabetic nephropathy (DN) is one of the most common complications diabetes mellitus (DM), and has been demonstrated as major causes renal failure. In a previous study, it was noted that microRNA let‑7a‑5p downregulated in DN; however, underlying mechanism requires additional investigation. The aim present study to investigate roles pathogenesis DN its associated mechanism. tissues db/db db/m mice, mesangial cells treated with high concentrations glucose were obtained; reverse...
Early-onset diabetes appears to be an aggressive phenotype of type 2 (T2D). The impact the age onset T2D on albuminuria, especially high urinary albumin excretion, remains investigated.
Adrenocortical carcinoma (ACC) is a rare malignant tumor with poor prognosis. Ferroptosis, new form of cell death, differs from other forms death and plays vital role in progress. Our study aimed to establish ferroptosis-related signature prognostic value ACC. RNA-seq data corresponding clinical characteristics for ACC were downloaded TCGA GEO databases. Genes included ferroptosis risk assessed by univariable multivariable Cox regression analysis as well lasso analysis. The the was using K-M...
The present study reported on an intrinsic property of gold nanoparticles (Au‑NPs), namely their ability to inhibit the proliferation and invasion thyroid carcinoma cells. Au‑NPs various sizes (5‑60 nm) were synthesized uptake into SW579 human cell line was verified using transmission electron microscopy (TEM). viability, apoptosis, cycle distribution invasive capacity cells assessed following treatment with a Cell Counting Kit‑8 assay, flow cytometric analysis Transwell as well fluorometric...
Diabetic nephropathy (DN) is one of the late complications diabetes, which seriously affects lives patients. Baicalin (BA) a flavone glycoside that has been identified to improve renal function in patients with DN. The present study aimed investigate roles and mechanisms BA For purpose, podocytes were cultured for 48 h under conditions high glucose (HG; 30 mM D-glucose) or normal (NG; 5 D-glucose). Then, cells treated different concentrations (6.25, 12.5 25 µM) 24 h. Cell viability apoptosis...
Adrenocortical carcinoma (ACC) is a rare malignancy with dismal prognosis. Hypoxia one of characteristics cancer leading to tumor progression. For ACC, however, no reliable prognostic signature on the basis hypoxia genes has been built. Our study aimed develop hypoxia-associated gene in ACC. Data ACC patients were obtained from TCGA and GEO databases. The included risk identified using Cox regression analysis as well LASSO analysis. GSEA was applied discover enriched sets. To detect possible...
Circular RNAs (circRNAs) are correlated with the occurrence and progression of differentiated thyroid cancer (THCA). However, regulatory mechanism circRNAs in THCA is unclear. In present study, we analyzed circRNA microarray dataset (GSE93522) tumors discovered that HACE1 (circHACE1) was downregulated THCA. We detected circHACE1 expression by quantitative real-time polymerase chain reaction (qRT-PCR). Gain-of-function experiments were performed to analyze biological function cells vitro. The...
Objective: To investigate the effect of volatile organic compounds (VOCs) exposure in atmosphere on risk daily death from stroke Guangzhou. Methods: Daily average concentrations twelve atmospheric VOCs, meteorological factors, and deaths for its subtypes (including ischemic hemorrhagic stroke) Guangzhou 2020 to 2021 were collected. The time-series Poisson generalized additive model was established analyze relationship between VOCs mortality a different lag days. season, gender, age group...
The accumulation of mitochondria in thermogenic adipose tissue (i.e., brown and beige fat) increases energy expenditure, which can aid alleviating obesity metabolic disorders. However, recent studies have shown that knocking out key proteins required to maintain mitochondrial function inhibits the expenditure fat, yet knockout mice are unexpectedly protected from developing or disorders when fed a high-fat diet (HFD). In present study, non-biased sequencing-based screening revealed...
<p dir="ltr">The accumulation of mitochondria in thermogenic adipose tissue (i.e., brown and beige fat) increases energy expenditure, which can aid alleviating obesity metabolic disorders. However, recent studies have shown that knocking out key proteins required to maintain mitochondrial function inhibits the expenditure fat, yet knockout mice are unexpectedly protected from developing or disorders when fed a high-fat diet (HFD). In present study, non-biased sequencing-based screening...
<p dir="ltr">The accumulation of mitochondria in thermogenic adipose tissue (i.e., brown and beige fat) increases energy expenditure, which can aid alleviating obesity metabolic disorders. However, recent studies have shown that knocking out key proteins required to maintain mitochondrial function inhibits the expenditure fat, yet knockout mice are unexpectedly protected from developing or disorders when fed a high-fat diet (HFD). In present study, non-biased sequencing-based screening...
Abstract Background: Pheochromocytoma is a rare neuroendocrine tumor originating from chromaffin cells in the adrenal medulla, and type of secondary hypertension. It mainly synthesizes secretes excessive catecholamines, causing series clinical symptoms, such as headache, sweating, palpitations, may be life-threatening severe cases. In current case report, we describe clinically manifesting pheochromocytoma with which landed crisis. Case presentation: The authors pheochromocytoma. A...