A5042259471- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Arsenic contamination and mitigation
- Global Cancer Incidence and Screening
- Nanoparticles: synthesis and applications
- Bone Tissue Engineering Materials
- Neonatal Health and Biochemistry
- Time Series Analysis and Forecasting
- Heavy Metal Exposure and Toxicity
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Diabetes Management and Education
- Cholesterol and Lipid Metabolism
- Cardiovascular Health and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Health Promotion and Cardiovascular Prevention
- Advanced Computational Techniques and Applications
- Global Public Health Policies and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Forecasting Techniques and Applications
Xinjiang Production and Construction Corps
2023-2025
Shihezi University
2015-2025
Jiangxi Provincial People's Hospital
2015-2020
Institute of Endemic Disease Control in Shandong Province
2018
Renji Hospital
2013
Chinese Academy of Sciences
2012
Institute of Mountain Hazards and Environment
2012
Chengdu University
2012
Nanjing Medical University
2009
Huaian First People’s Hospital
2009
Abstract The present studies describe the fabrication and characterization of highly porous interconnected poly(α‐hydroxy acid) foam scaffolds produced using a phase separation multisolvent system, followed by sublimation process. Fabrication parameters, including solvent composition, polymer concentration, freezing temperature, type, molecular weight, were optimized to produce desired microstructure. Analyses selected samples with scanning electron microscopic images mercury intrusion...
Abstract This study was designed to determine if the surface modification of porous poly(lactic acid) (PLA) scaffolds would enhance osteogenic precursor cell (OPC) attachment, growth, and differentiation. A covalently grafted amino group (−NH 2 ), poly( L ‐lysine) (PLL), peptide arginine‐glycine‐aspartic acid (RGD) were selected for evaluation. The hypothesis that have a positive impact on cell–substratum interactions. experiment performed by OPC cells being placed PLA films modified with NH...
Abstract Understanding the burden associated with occupational asbestos exposure on a global and regional scale is necessary to implement coordinated prevention control strategies. By GBD Study 2019, we conducted comprehensive assessment of non-communicable diseases attributable exposure. In 239,330 deaths 4,189,000 disability-adjusted life years (DALYs) worldwide due occurred. 1990–2019, DALYs attributed increased by 65.65% 43.66%, respectively. Age-standardized mortality rate (ASMR)...
ABSTRACT Titanium dioxide nanoparticles (TiO 2 NPs) can induce the cell cycle arrest in spermatogonia, and JAK2/STAT3 signaling pathway plays a pivotal role progression, but specific upstream regulatory mechanisms are not completely clarified. The purpose of this study was to investigate whether CXCL13 regulated participate after mouse spermatogonia line (GC‐1) exposure TiO NPs. GC‐1 cells were treated with NPs at different concentrations (0, 10, 20, 30, 40 μg/mL) for 24 h detect viability,...
More than 90% of deaths due to breast cancer (BC) are metastasis-related complications, with invasive ductal carcinoma (IDC) the being most common pathologic type and highly susceptible metastasis distant organs. BC patients who develop metastases more likely have a poor prognosis quality life, so it is extremely important recognize diagnose whether occurred in IDC as early possible. In this study, we non-invasive classification system for detecting metastasis. We used Anaconda-Jupyter...
A tissue-engineered bone biomimetic device was developed to regenerate calvaria critical-sized defects (CSDs) in athymic rats. Well-documented evidence clearly confirms that left untreated, CSDs will not spontaneously bone. To accomplish regeneration, four candidate treatments were assessed: porous poly(D,L-lactide) and type I collagen (PLC), PLC human osteoblast precursor cells (OPCs) at 2 x 10(5) (PLC/OPCs), 50 microg of recombinant morphogenetic protein-2 (PLC/rhBMP-2), PLC/OPCs/rhBMP-2...
Two new grafted polysiloxane polymers, a copolysiloxane and terpolysiloxane, have been synthesized. Both backbones are with dialkyl disulfide chains 600 MW methoxy-terminated poly(ethylene glycol) (PEG) chains, while the terpolysiloxane also has 3400 PEG side terminated N-hydroxysuccinimide (NHS) reactive ester groups. The two polymers spontaneously form monolayers on gold surfaces estimated thicknesses of 23 31 Å, respectively. Combined analysis angle-dependent X-ray photoelectron...
To investigate the effects of grape seed proanthocyanidin extract (GSPE) on oxidative damage and arsenic (As) methylation to clarify role Nrf2 in process. L-02 cells were treated with (25 μM) GSPE (10, 25, 50 mg/L) for 24 h. Cell viability was analyzed by MTT assay. apoptosis ROS fluorescence detected flow cytometry. Oxidative stress marker levels measured using commercial kits. mRNA protein expression qRT-PCR western blotting. The cellular concentrations products HPLC-HGAFS. Arsenic ability...
Abstract Although nonviral vectors have lower transfection efficiency than viral vectors, the excellent safety profile of is appealing for gene therapy. An efficient, simple vector delivery system has been designed that includes plasmid DNA–calcium phosphate precipitates (pDNA‐CaP) and porous collagen spheres (Cultispheres™). The hypothesis this study was pDNA‐CaP would achieve efficient DNA provide a suitable carrier three‐dimensional (3D) administration. To test hypothesis, including LacZ...
Abstract Background To externally validate the Prediction for ASCVD Risk in China (PAR) risk equation predicting 5-year atherosclerotic cardiovascular disease (ASCVD) Uyghur and Kazakh populations from rural areas northwestern compare its performance with those of pooled cohort equations (PCE) Framingham score (FRS). Methods The final analysis included 3347 subjects aged 40–74 years without CVD at baseline. was calculated using PAR, PCE, FRS. Discrimination, calibration, clinical usefulness...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic in China. Our study aimed to evaluate screening value of index (FLI), hepatic steatosis (HSI), lipid accumulation product (LAP), visceral adiposity (VAI), and Zhejiang University (ZJU), as well other single indicators for MAFLD. We find optimal tool its appropriate cut-off values rural Uyghur adults.We completed a survey 14,321 adults 51 groups Kashgar, Xinjiang, 2016 using typical sampling method, with...
Background and aims Maternal malnutrition is a major global public health problem that can lead to serious maternal diseases. This study aimed analyze predict the spatio-temporal trends in burden of disorders attributable malnutrition, provide basis for scientific improvement targeted prevention disorders. Methods Data on including number deaths, disability-adjusted life years (DALYs), population fractions (PAFs), age-standardized mortality rates (ASMRs), DALY (ASDRs) were obtained from...
Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the of developing cardiovascular diseases (CVD). Previous studies that compared FRS MS have focused on high-income urban areas. This study comparison between when in nomadic minorities mountain Moreover, an applicable tool CVD was identified. 2,286 participants who were recruited from far west China followed-up a median 5.49 years. terms their ability development using Cox regression receiver operating...
This study aims to investigate association between six single nucleotide polymorphisms(SNPs) in APOA1 gene and types of obesity with the risk low level HDL-C pastoral area northwest China. A total 1267 individuals including 424 patients disease 843 health subjects were analyzed based on matched for age, sex. SNPShot technique was used detect genotypes rs670, rs5069, rs5072, rs7116797, rs2070665 rs1799837 gene. The relationship above SNPs by binary logistic regression. Carriers rs670 G allele...
Arsenic-induced respiratory inflammatory damage is an important occupational hazard in many areas of the world, particularly underdeveloped and developing countries. Effective treatments are lacking expensive. Therefore, aim study was to examine anti-inflammatory effects proanthocyanidin (PC) molecular mechanisms vivo vitro. The present showed that PC extracted from grape seed could attenuate lung a mouse model arsenic poisoning. were observed at level histology inflammasome expression. This...
To study the corresponding strategies for controlling cancer in older adults aged 60 and above China, a comprehensive assessment of disease burden is required. Therefore, we will introduce epidemiological characteristics China over recent 12 year period.The age-period-cohort model was constructed using incidence data from Chinese Cancer Registry Annual Report published 2008-2019. The annual change percentage (APC) estimated by log-linear regression to reflect time trend. GLOBOCAN 2020...
Objective: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well relationship each component of MS. Methods: A total 571 individuals which were randomly selected from 5692 Uyghur adults subdivided into two groups, including 280 patients with MS 291 control subjects, using group-matching method after matching for gender. We detected (rs5882, rs1800775, rs3764261, rs12149545, rs711752, rs708272) by Snapshot method. Results: (1) Significant differences...