A5045319191- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Contact Dermatitis and Allergies
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Ion Channels and Receptors
- Psoriasis: Treatment and Pathogenesis
- Pediatric health and respiratory diseases
- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
Guangzhou Medical University
2019-2024
State Key Laboratory of Respiratory Disease
2020-2024
Second Affiliated Hospital of Guangzhou Medical University
2020-2023
Spinal astrocytes contribute to chronic itch via sensitization of itch-specific neurons expressing gastrin-releasing peptide receptor (GRPR). However, whether microglia-neuron interactions remains unclear. In this study, we aimed explore how microglia interact with GRPR+ and promote itch.RNA sequencing, quantitative real-time PCR, western blot, immunohistochemistry, RNAscope ISH, pharmacologic genetic approaches were performed examine the roles spinal NLRP3 (The NOD-like family,...
Staphylococcal enterotoxin A (SEA) is a well-known superantigen and stimulates human peripheral blood mononuclear cells (PBMCs) involving in the pathogenesis of inflammatory disorders cancer.To better understand biological activities SEA possible intracellular mechanisms by which plays its roles conditions like staphylococcal and/or autoimmune immunotherapy.Recombinant (rSEA) was expressed prokaryotic expression system effects on cytokine chemokine production examined Enzyme-linked...
Background: Recurrent and intractable chronic itch is a world-wide problem but mechanisms, especially the neural underlying still remain unclear. In this study, we investigated peripheral spinal mechanisms responsible for prolonged in mouse model of allergic contact dermatitis induced by squaric acid dibutylester (SADBE). Methods: Behavioral tests combination to genetic, pharmacological, neurotoxic approaches were performed on models. Immunohistochemistry, RNAscope situ hybridization assay,...
Abstract Pseudomonas aeruginosa induced acute lung injury is such a serious risk to public health throughout the world, but pathological regulation remains unclear. Here, we reported that P. ae mediated epithelial necroptosis leads subsequent immune responses and plays an important role in pulmonary process. Pharmacological genomic ablation of signaling ameliorate inflammation. Our results further proved NLRP3 inflammasome involve ALI. Mechanism investigation revealed cross-talking patterns...