A5101406012- Transportation Planning and Optimization
- Railway Systems and Energy Efficiency
- TGF-β signaling in diseases
- Metaheuristic Optimization Algorithms Research
- Advanced Multi-Objective Optimization Algorithms
- Railway Engineering and Dynamics
- Kruppel-like factors research
- Advanced Algorithms and Applications
- Urban and Freight Transport Logistics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cloud Computing and Resource Management
- Software System Performance and Reliability
- Cancer-related molecular mechanisms research
- IoT and Edge/Fog Computing
- Wnt/β-catenin signaling in development and cancer
Central South University
2006-2025
Xiangya Hospital Central South University
2016
Peking University
2012
Hunan University of Science and Engineering
2008
Central South University of Forestry and Technology
2008
// Xiaodan Fu 1, 2 , Yimin Li Ayesha Alvero 3 Juanni Qihui Wu Qing Xiao Yulong Peng Yongbin Hu Xiang Wenguang Yan 5 Ke Guo 6 Wenjuan Zhou 7 Yong Wang 8 Junwen Liu 9 Yu Zhang 4 Gil Mor Jifang Wen Gang Yin 1 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China School Basic Medical Sciences, Obstetrics, Gynecology and Reproductive Immunology Unit, Yale University Medicine, New Haven, CT, USA Gynecology, Rehabilitation, The Third Internal...
In the transportation organization optimization of high-speed railway (HSR), optimizations such as line planning, ticket pricing, and seat allocation are generally studied separately. However, in reality, when passengers choose trains, they need to consider multiple factors train routes, stop plans, prices, availability, departure times. Therefore, there is an urgent for integrated method simultaneously make decisions regarding these factors. This study constructs a nonlinear model planning...
This paper is devoted to designing a mixed-integer linear programming solve the simultaneous line planning and timetabling problem. A directed graph first constructed represent combinational travel network for both candidate trains passengers. Through this graph, it easy simultaneously describe trains' operation choices, passengers' their restrictive relations. Based on it, model with many binary non-negative integer decision variables built optimize plan, timetable, passenger which can be...
Estimating the cost is important for cloud application developers to services in clouds, and becomes even when it needs remaining a certain service level at same time. Though currently much work has been down predict performance of applications, most them perform either before design or after construction, which leads imprecise estimation irreparable fault. In this paper, we propose an approach estimate running typical applications Amazon Web Service (AWS) during phase. We UML...
Recently particle swarm optimization (PSO) algorithm gained popularity and employed in many engineering applications because of its simplicity efficiency. The performance the PSO can further be improved by using hybrid techniques. There are various algorithms published literature where researchers combine benefits with other heuristics algorithms. In this paper, we propose a cooperative line search (CLS-PSO) integrating local technique basic (B-PSO). proposed algorithm, examined through four...
Line planning problems and differential pricing are complementary processes in the railway system, but these two were generally considered separate most of existing literature. This paper studies a time-dependent line problem with passenger train choice high-speed networks under elastic origin-destination-period demand. After clearly flexibly describing organization cost operators, price cost, time passengers physical infrastructure-based directed graph, non-linear joint optimization model...
This paper is devoted to developing a line-planning approach for high-speed railway networks merging newly built lines, which result in the change of network’s original structure and some passengers’ travel routes. In order exactly describe choice time-varying passengers operation trains, passenger network with time information constructed based on pre-generated candidate train set. Following this, optimization model optimizing trains both existing merged new line established under...
Recently, variants of hybrid PSO algorithms are presented, but Optimization technique combining classical local line search with is less focused on. In this paper, we proposed a new cooperative evolutionary algorithm by integrating and basic PSO. The performance our tested using four typical nonlinear optimization problems reported compared that Results show CLS-PSO much better than PSO, has considerable steady robust.
Objective To investigate the role of extracellular signal-regulated kinase (ERK)/activator protein-1 (AP-1) signaling pathway in SiO2-induced plasminogen activators inhibitor-1 (PAI-1) protein expression human lung epithelial cells A549. Methods A549 were cultured and then stimulated with 200 μg/ml SiO2 for 0-24 h. prevent AP-1 activity,Curcumin was added into culture medium before incubated transient TAM-67 tranfection performed. In addition, PD98059 pretreated to ERK activity. The PAI-1...