A5100774456- Ovarian function and disorders
- Endometriosis Research and Treatment
- Nutrition, Genetics, and Disease
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Corrosion Behavior and Inhibition
- Sperm and Testicular Function
- Metal Extraction and Bioleaching
- Ginseng Biological Effects and Applications
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Connective Tissue Growth Factor Research
- Phytoestrogen effects and research
- Blood Coagulation and Thrombosis Mechanisms
- Biosimilars and Bioanalytical Methods
- Pregnancy and preeclampsia studies
- Cancer-related gene regulation
- Omental and Epiploic Conditions
- Pregnancy-related medical research
- Endometrial and Cervical Cancer Treatments
- Gut microbiota and health
- Pharmacological Effects and Toxicity Studies
- Cancer, Hypoxia, and Metabolism
Lanzhou University
2007-2024
First Hospital of Lanzhou University
2018-2024
Third Xiangya Hospital
2020-2021
Central South University
2017-2021
Xiangya Hospital Central South University
2021
Second Military Medical University
2020
Eastern Hepatobiliary Surgery Hospital
2020
Ministry of Education of the People's Republic of China
2020
First Affiliated Hospital of Anhui Medical University
2019
Anhui Medical University
2019
Aim Sarcopenia and sarcopenic obesity are significant associative factors for functional impairment related to aging. The main aim of the present study was investigate prevalence sarcopenia obesity, their associations with status among men aged 80 years older in B eijing. Methods A total 75 young healthy volunteers, 101 participated study. Demographic characteristics, anthropometry, skeletal muscle mass measured by dual X ‐ray absorptiometry ( DXA ), 6‐m gait speed handgrip strength were...
Purpose: MicroRNAs (miRNAs) are key regulators of the growth and development a wide range cancer types such as colorectal (CRC). A number previously studies have observed that levels miR-365a-3p expression dysregulated in many cancers, but specific role this miRNA CRC its association with patient prognosis remains unclear. Methods: The tissues cell lines was detected by Real-time Quantitative polymerase chain reaction (RT-qPCR), while relationship between clinicopathological characteristics...
RBMS3, a gene encoding glycine-rich RNA-binding protein, belongs to the family of c-Myc single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in diverse range solid tumors and played critical role tumor progression. However, it remains unclear whether inhibits progression human breast cancer. Thus, aim this study investigate cancer explore underlying mechanism Our results showed, for first time, expression at both mRNA protein...
The association between suboptimal pre-pregnancy body mass index (BMI) and small-for-gestational-age (SGA) infants is not well defined. We investigated the BMI risk of SGA in a Chinese population. performed cohort study among 12029 mothers with pregnancy. This consisted pregnant women that were: normal-weight (62.02%), underweight (17.09%), overweight (17.77%) obese (3.12%). Birth sizes were reduced groups compared group. Linear regression analysis indicated birth size was positively...
Endometriosis (EMS) is a common gynecological disease. Prostaglandin E2 (PGE2), which induces chronic pelvic inflammation and cell pyroptosis, form of programmed death based on inflammasome activation, are involved in EMS, but the extent their involvement roles remain unclear. The present study aimed to evaluate PGE2-induced pyroptosis EMS influence PGE2 progression. Using western blotting, it was found that expressions pyroptosis-related proteins (NLRP3, cleaved caspase-1, interleukin...
This study aimed to investigate the impact of intrauterine adhesions (IUA) therapy and endometrial receptivity by implanting autologous bone marrow mesenchymal stem cells (BMSCs) into Interceed subsequently placing them in uterine cavity rats. Fifty rats were divided 5 groups according random number table method (10 each group). Following development IUA model through mechanical injury, animals categorized different treatment groups: (intrauterine perfusion saline), placement Interceed),...
The genetic variability among 32 Chinese Acidithiobacillus spp. environmental isolates and four reference strains representing three recognized species of the genus was characterized by using a combination molecular methods, namely restriction fragment length polymorphisms PCR-amplified 16S rRNA genes 16S-23S gene intergenic spacers, repetitive element PCR, arbitrarily primed PCR sequence analyses. sequences revealed that all could be assigned to seven groups, which encompassed ferrooxidans...
The complete sequences of 32 intergenic spacer regions (ISR) from Acidithiobacillus strains, including 29 field strains isolated coal, copper, molybdenum mine wastes or sediment different geoclimatic in China, reference strain ATCC19859 and the type two species were determined. These data, together with other available GenBank database, used to carry out first detailed assessment inter- intraspecific genomic variability ISR infer phylogenetic relationships within genus. total length 16S-23S...
This study aimed to explore the possibility of miR-423-5p modified adipose-derived stem cell (ADSCs) therapy on streptozotocin (STZ)-induced diabetes mellitus erectile dysfunction (DMED) rats. MiR-423-5p was knocked down in ADSCs. ADSCs, NC-miR-ADSCs and miR-ADSCs were co-cultured with human umbilical vein endothelial cells (HUVECs). Normal high glucose media supplemented. The supernatant HUVECs collected for assessment eNOS VEGFa expression, proliferation, apoptosis. ADSCs or exhibited...
Metformin, a drug used to treat type 2 diabetes, has gained attention for its multiple therapeutic applications. However, little is known about effects on human sperm function at therapeutically relevant concentration.The aim of this study was elucidate the in vitro actions metformin and explore underlying mechanism any effects.Human ejaculated spermatozoa were treated with concentrations (0.25, 5, 10, 20, 40, 80 µM) vitro. Fertilization-essential functions examined, including viability,...
To explore the effects of miR-21 on rats with proliferative diabetic retinopathy by regulating transforming growth factor-beta (TGF-β) signaling pathway.A total 36 Sprague-Dawley were randomly divided into normal group (n=12), model and inhibitor (TGF-β inhibitor) (n=12). No treatment was performed in group, established after intraperitoneal injection inhibitor. Then, materials sampled for detection. In each retinal morphology observed via hematoxylin-eosin (HE) staining, expressions TGF-β1...
Premature ovarian insufficiency is characterized by reduced function in a young woman, resulting an earlier menopause compared with women normal function. It term that reflects the variable nature of condition and substantially less emotive than formerly used ‘premature failure’, which suggested single event time. Tripterygium glycosides can damage cause infertility. This case report describes 33-year-old female patient (gravida 0, parity 0) who presented premature after being treated...
The purpose of the present study was to evaluate associations between seven tagging single nucleotide polymorphisms (tSNPs) and risk breast cancer assessed by tumor pathological characteristics body mass index (BMI).Seven tSNPs four susceptibility genes were analyzed in 734 Chinese women with 672 age-matched healthy controls; then, association clinicopathological characteristics, BMI, molecular subtype, TNM (T, tumor; N, lymph node; M, metastasis) staging node status determined unconditional...
Despite progress achieved in cancer chemotherapy recent decades, adverse effects remain a limiting factor for number of patients with colorectal cancer, suggesting the requirement novel therapeutic strategies. Gene therapy appears to be promising strategy treating cancer. The present study aimed investigate anti-tumor effect combined gene therapy, using Survivin downregulation by RNAi and fusion suicide yCDglyTK system. A triple-gene vector expressing Survivin-targeted small hairpin RNA...