A5101558824- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Amoebic Infections and Treatments
- Assembly Line Balancing Optimization
- Neonatal Health and Biochemistry
- Drug-Induced Hepatotoxicity and Protection
- Iron Metabolism and Disorders
- Viral-associated cancers and disorders
- Antibiotic Resistance in Bacteria
- Infections and bacterial resistance
- Colorectal Cancer Treatments and Studies
- Hepatitis Viruses Studies and Epidemiology
- Orthopaedic implants and arthroplasty
- Inflammatory Myopathies and Dermatomyositis
- Hematopoietic Stem Cell Transplantation
- Liver Diseases and Immunity
- Glycogen Storage Diseases and Myoclonus
- Carbohydrate Chemistry and Synthesis
- Lysosomal Storage Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Impact of Light on Environment and Health
Nanjing Agricultural University
2025
Jilin University
2005-2024
First Hospital of Jilin University
2005-2024
Weatherford College
2019
Objective China’s national hepatitis burden is high. This study aims to provide a detailed national-level description of the reported incidence viral in China during 2004–2016. Design Observational study. Setting Data were obtained from National Notifiable Disease Reporting System, and changing trends estimated by joinpoint regression analysis. Participants In this system, 16 927 233 cases occurring 2004–2016 identified. Primary outcome measure Incidence rates per 100 000 person-years...
GALAD is a statistical model for estimating the likelihood of having hepatocellular carcinoma (HCC) based on gender, age, AFP, AFP-L3, and PIVKA-II. We aimed to assess its performance build new models in China, where hepatitis B virus (HBV) leading etiology HCC. built GALAD-C with same five variables GALAD, GAAP PIVKA-II, using logistic regression 242 patients HCC 283 chronic liver disease (CLD). also collected 50 other malignant tumors (OMTs) healthy controls (HCs). A test dataset (169 139...
Urban waterfront areas, which are essential natural resources and highly perceived public areas in cities, play a crucial role enhancing urban environment. This study integrates deep learning with human perception data sourced from street view images to the relationship between visual landscape features of employing linear regression random forest models predict along coastal roads. Based on aesthetic distinctiveness perception, roads Xiamen were classified into four types different emphasis...
Rationale: Zieve syndrome, a rarely reported disease resulting from alcohol abuse, consists of triad symptoms: hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. It is largely under-recognized under-reported, possibly because unawareness the condition by physicians. Here, we report case syndrome managed at Jilin University First Bethune Hospital. Patient concerns: A 30-year-old Chinese woman presented with 4-month history fatigue, yellowish discoloration eyes, tea-colored...
Benzbromarone is a uricosuric agent that reduces proximal tubular reabsorption of uric acid. Because hepatotoxicity, it has been withdrawn from the market in Europe. Recently, some benefit-risk assessments benzbromarone suggest greater benefits than risks, and application treatment gout hyperuricemia still under debate.A 39-year-old man was admitted to hospital for icterus nausea, he treated with (100 mg/d) 4 mo because hyperuricemia. He had 10-year history beer drinking (alcohol: about 28...
Background: We aimed to discover potential gene biomarkers for gastric cancer (GC) diagnosis.Materials and Methods: Genechips of 10 GC tissues mucosa (GM, para-carcinoma tissue, normal control) were generated using an exon array Affymetrix containing 30,000 genes.The differentially expressed genes (DEGs) between control identified by the Limma package analyzed hierarchical clustering analysis.Gene ontology (GO) pathway enrichment analyses performed investigating functions DEGs.Receiver...
Alcohol-associated liver disease is exhibiting an increasing burden. In terms of pathogenesis, inflammation closely related to alcohol-induced injury. The neutrophil-to-lymphocyte ratio (NLR) a novel inflammatory biomarker. Here, we aim evaluate the role NLR and other biomarkers in predicting short-term mortality alcoholic cirrhotic patients.This was retrospective study that included 459 male cirrhosis patients. Among them, 345 patients completed follow-up. Based on their 30-day information,...
We investigated the pathogenesis of a patient with severe acute pancreatitis by comprehensively analysing rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae (CR-HvKP) strain. conducted virulence and multidrug-resistance phenotypic characterization identified CR-HvKP strain from patient. It was subjected to Pacbio sequencing, subsequent analysis virulence, resistance genes mobile genetic elements. described phenotype genotype an untypeable blaKPC-harboured conjugative...
This study aimed to summarize the clinical and microbiological characteristics of patients with pyogenic liver abscess (PLA) explore features PLA extrahepatic migratory infection (EMI). A retrospective analysis was conducted on data from 1800 at Jilin University First Hospital January 2019 December 2023. Patients were divided into two groups based presence EMI: EMI without EMI. Clinical prognoses compared using rank-sum tests chi-square for continuous categorical data, respectively....
Background: Although several prognostic scores have been reported to correlate with the prognosis of primary biliary cholangitis (PBC) patients, there are limited tools predict PBC compensated cirrhosis. This study aimed evaluate performance albumin-bilirubin (ALBI) score in patients Methods: We conducted a retrospective longitudinal 219 cirrhosis ALBI using Cox regression model, receiver operating characteristic (ROC) curve, and Kaplan-Meier method. Results: During follow-up, total 19...
Abstract Rationale: Hereditary hemochromatosis (HH) is a frequent autosomal recessive disease. The pathogenesis of disease excessive intestinal absorption dietary iron, resulting in pathologically high iron storage tissues and organs. As systemic disease, it has several manifestations including cirrhosis, diabetes mellitus, cardiomyopathy, joint However, proportion patients are asymptomatic. Patient concerns: A 34-year-old man who had abnormal liver function for 9 months without specific...
Objective: The aim was to investigate the genotype distribution of two major epitopes large surface protein (PreS1) hepatitis B in Chinese patients and explore association between genotypes these epitopes, determine whether PreS1 full-length could be revealed according polypeptide sequence key epitopes. Methods: HBV DNA extracted from serum for PCR amplification. 278 samples amplified successfully were sequenced compared with known sequences Genbank (amino acid epitope 21-47 94-117,...
Einleitung Das Risiko eines HCC-Rezidivs nach einer Leberresektion oder -ablation mit kurativer Intention ist hoch, daher bedarf es wirksamer adjuvanter Therapien. Atezolizumab (Atezo)+Bevacizumab (Bev) stellt den Therapiestandard bei nicht resezierbarem HCC dar, da im Vergleich zu Sorafenib statistisch signifikante und klinisch bedeutsame Verbesserungen hinsichtlich des Gesamtüberlebens (OS), progressionsfreien Überlebens der objektiven Ansprechrate zeigte (IMbrave150-Studie).