A5100706798- Pharmacy and Medical Practices
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Pancreatic function and diabetes
- Traditional Chinese Medicine Studies
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmaceutical studies and practices
- Botulinum Toxin and Related Neurological Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Diabetic Foot Ulcer Assessment and Management
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Mycobacterium research and diagnosis
- Diabetes and associated disorders
- Acute Lymphoblastic Leukemia research
- Mesenchymal stem cell research
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Pain Mechanisms and Treatments
Capital Medical University
2007-2025
Beijing Tian Tan Hospital
2007-2025
Hebei Medical University
2024
Henan Provincial People's Hospital
2011-2023
Zhengzhou University
2015-2023
Tianjin Medical University Cancer Institute and Hospital
2023
Renmin University of China
2016
Zhengzhou People's Hospital
2008-2013
Because of the rapid change in lifestyle China, there is concern that diabetes may become epidemic. We conducted a national study from June 2007 through May 2008 to estimate prevalence among Chinese adults.
Background We updated the prevalence of obesity and evaluated clinical utility separate combined waist circumference (WC) or body mass index (BMI) category increments in identifying cardiometabolic disorder (CMD) cardiovascular disease (CVD) risk Chinese adults. Methods Findings 46,024 participants aged ≥20 years, a nationally representative sample surveyed 2007–2008, were included this analysis. Taking cutoffs recommended by Joint Committee for Developing Guidelines (JCDCG) Working Group on...
Aim To investigate the association between different family history risk categories and prevalence of diabetes in Chinese population. Methods The was obtained from each subject, an oral glucose tolerance test performed for measuring fasting postload insulin levels based on a national representative cross-sectional survey 46,239 individuals (age ≥ 20 years) 2007–2008 China National Diabetes Metabolism Disorders Study. were high, moderate, average (FH2 FH1: at least two generations one...
This study aims to investigate the pharmacokinetics of methotrexate (MTX) in Chinese patients with intracranial germ cell tumors (iGCTs) and develop a robust population pharmacokinetic (PPK) model. A two-compartment model an exponential inter-individual variability proportional residual was established using nonlinear mixed-effects modeling. The based on 5,470 plasma concentration data points from 505 iGCT patients, including 370 children. impact covariates parameters evaluated forward...
To investigate the prevalence and associated risk factors of microalbuminuria, to explore relationship between albuminuria cardiovascular disease (CVD). A nationally representative sample 38,203 Chinese participants was categorized by different levels urinary albumin-to-creatinine ratio (ACR; 0 -10 mg/g, 10 -20 20 -30 30 -300 mg/g). The compared using a single ACR cut-off point sex-specific points. Factors with presence albuminuria, CVD were analyzed logistic regression. Prevalence as...
Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim this study to determine prevalence CVDs and risk factors Chinese impaired glucose regulation subjects.We used a multistage, stratified sampling method select subjects from general population aged 20 years older. Subjects underwent an oral tolerance test identify normal (NGT) including isolated fasting (i-IFG), (i-IGT), combined IFG/IGT diabetic mellitus (DM). A logistic regression analysis was...
Different studies have produced conflicting results regarding the association between smoking and diabetes mellitus, detailed analysis of this issue in Chinese males based on nationwide samples is lacking. We explored cigarette newly-diagnosed mellitus (NDM) using a population-based case-control analysis; 16,286 male participants without previously diagnosed were included. Prediabetes NDM oral glucose tolerance test. The cohort included 6,913 non-smokers (42.4%), 1,479 ex-smokers (9.1%)...
Background: Perampanel is a promising epilepsy treatment with an innovative mechanism of action. This study was performed to investigate the factors affecting perampanel clearance in population pharmacokinetic (PPK) model Chinese pediatric and adult patients epilepsy. Methods: A total 135 plasma concentrations from 125 were analyzed using PPK nonlinear mixed-effects modeling. One-compartment proportional residual models best described pharmacokinetics perampanel. Covariate effects on...
To investigate the prevalence of adult-onset autoimmune diabetes (ADM) and predisposition to diseases by quantifying serum organ-specific autoantibodies in people with phenotype type 2 (T2D).We included a nationally representative sample 46 239 adults aged ≥20 years from 14 provinces, whom 4671 had diabetes, plus 1000 control subjects normal glucose tolerance (NGT). Participants were screened centrally for glutamic acid decarboxylase (GAD), islet antigen (IA2) zinc transporter isoform-8...
Background and Aims Obesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified number of genetic loci associated with obesity. The aim this study to examine the contribution obesity-related genomic diabetes in Chinese population. Methods We successfully genotyped 18 single nucleotide polymorphisms among 5338 diabetic patients 4663 controls. Both individual joint effects these on quantitative glycemic traits (assessing β-cell function insulin...
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with normal islets. dysfunctional pathways, transcription factor, microRNA analyzed by bioinformatics methods. Moreover, a group bioactive small molecules identified based on connectivity map database. pathways Eicosanoid Synthesis, TGF-beta signaling pathway,...
Abstract Selective peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) agonist affects the functions of endothelial progenitor cells (EPCs). This study explores effect selective PPAR‐γ agonist, pioglitazone, on EPC apoptosis. The were cultured and identified via double staining method in a medium containing different concentrations pioglitazone. apoptosis was detected by flow cytometry. On Day 7, EPCs engulfed DiL‐ac‐LDL FITC‐UEA‐1, showed yellow fluorescence laser‐scanning confocal...
Thyroid function is associated with the etiology and pathogenesis of type 2 diabetes (T2D) potentially contributes to development complications T2D. The association thyroid hormones atherosclerosis in euthyroid T2D patients not clear.To investigate hormone levels risk developing Central China.This cross-sectional study recruited 910 from Henan Provincial People's Hospital, China. Association among hemoglobin A1c (HbA1c), hormones, prevalence was assessed by multivariable Cox models after...
Background Though multiple single nucleotide polymorphisms (SNPs) associated with type 2 diabetes have been identified, the genetic bases of isolated fasting hyperglycaemia (IFH) and postprandial (IPH) were still unclear. In present study, we aimed to investigate association genome-wide study-validated variants IFH or IPH in Han Chinese. Methods/Principal Findings We genotyped 27 validated SNPs 6,663 unrelated individuals comprising 341 IFH, 865 IPH, 1,203 combined hyperglycaemia, 4,254...
To investigate the prevalence of microalbuminuria (MAU) among Chinese individuals without diabetes and relationship between MAU metabolic factors, individual socioeconomic status (SES), regional economic development level.Cross-sectional study MAU.152 urban street districts 112 rural villages from northeast, north, east, south central, northwest southwest China.46 239 participants were recruited using a multistage stratified sampling design 2007 to 2008. A total 41 290 determined by oral...
This study aimed to investigate whether single nucleotide polymorphisms (SNPs) located near the gene of ABO blood group play an important role in genetic aetiology menstrual disorders (MDs). Polymerase chain reaction-ligase detection reaction technology was used detect eight SNPs location on chromosomes 250 cases MD and normal menstruation. The differences distribution each genotype, as well allele frequency control groups, were analysed using Pearson's χ2 test search for disease-associated...
We reported a case of 60-year-old male with fever, cough, expectoration, and chest distress after right lung transplanted. Blood examination showed elevated C-reaction protein (CRP), white blood cell (WBC), ammonia. Computed tomography (CT) revealed patchy high-density shadows few pleural effusions in the transplanted lung. Bronchoscopy illustrated anastomotic fistula, pseudomembrane mucus plugs around main bronchial anastomosis. Carbapenem-resistant Klebsiella pneumoniae, Ureaplasma...