A5077820275- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diabetes Management and Research
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Education
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Peroxisome Proliferator-Activated Receptors
- Firm Innovation and Growth
- Cardiovascular Health and Risk Factors
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Chronic Kidney Disease and Diabetes
- Chronic Disease Management Strategies
- Cancer-related molecular mechanisms research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- RNA modifications and cancer
- Blood Pressure and Hypertension Studies
Tsinghua University
2018-2025
Beijing Tsinghua Chang Gung Hospital
2018-2025
Ningde Normal University
2021-2023
China-Japan Friendship Hospital
2002-2019
Lishui University
2013-2017
Sichuan University
2015
Peking University People's Hospital
2012-2013
Peking University
2012-2013
Sun Yat-sen University
2012
Chinese PLA General Hospital
2012
Because of the rapid change in lifestyle China, there is concern that diabetes may become epidemic. We conducted a national study from June 2007 through May 2008 to estimate prevalence among Chinese adults.
Aims The present study aimed to assess the prevalence of hypertension among Chinese adults. Methods Data were obtained from sphygmomanometer measurements and a questionnaire administered 46239 adults ≥20 years age who participated in 2007–2008 China National Diabetes Metabolic Disorders Study. Hypertension was defined as blood pressure ≥140/90 mm Hg or use antihypertensive medication. Results A total 26.6% had hypertension, significantly greater number men hypertensive than women (29.2% vs...
Because of rapid change in lifestyle risk factors, cardiovascular disease has become the leading cause death China. We sought to estimate national levels serum lipids and lipoproteins among Chinese adult population.We conducted a cross-sectional study nationally representative sample 46 239 adults aged ≥20 years. Fasting total, high-density lipoprotein, low-density lipoprotein cholesterol triglycerides were measured by standard methods. The age-standardized estimates 4.72 (95% confidence...
To develop a New Chinese Diabetes Risk Score for screening undiagnosed type 2 diabetes in China.Data from the China National and Metabolic Disorders Study conducted June 2007 to May 2008 comprising 16,525 men 25,284 women aged 20-74 years were analyzed. Undiagnosed was detected based on fasting plasma glucose ≥7.0 mmol/L or 2-h ≥11.1 people without prior history of diabetes. β-Coefficients derived multiple logistic regression model predicting presence used calculate Score. The performance...
Background The Diabetes Impact Study followed up a large national population-based screening study to estimate the use of and expenditures for medical care caused by diabetes in China ascertain cost essential basic medicines care. Methods In 2009–10, team interviewed 1482 adults with 1553 glucose tolerance normal range from random samples at 12 sites China. response rate was 67%. Findings After adjusting age, sex, urban/rural location, people received 1.93 times more days inpatient...
Background and Aims Ghrelin, a neuropeptide containing 28 amino acids, shows reciprocal diurnal plasma fluctuation to that of insulin. The aim this study is clarify the doseand glucose-dependency ghrelin on insulin secretion compare its effect with other neuropeptides—GLP-1, CART (55-102), (55-76), (62-76), MCH, orexin A, B. Materials Methods Rat islets were incubated 1 pmol/l–1 μmol/l ghrelin, fragments, A or B, GLP-1 (n = 16–32) in presence 16.7 mmol/l glucose. Ghrelin (10 nmol/l) was...
Purpose This study investigates the incidence, predictors, and preventive strategies for microvascular complications in type 2 diabetes patients community settings. Methods Data were collected from 3,008 enrolled across 31 clinics Beijing Hebei. Prevalence incidence of diabetic kidney disease (DKD), retinopathy (DR), peripheral neuropathy (DPN) assessed. Predictors identified using XGBoost Cox regression, impact lifestyle multifactorial interventions (MFI) was analyzed. Results The...
Aim To investigate the association between different family history risk categories and prevalence of diabetes in Chinese population. Methods The was obtained from each subject, an oral glucose tolerance test performed for measuring fasting postload insulin levels based on a national representative cross-sectional survey 46,239 individuals (age ≥ 20 years) 2007–2008 China National Diabetes Metabolism Disorders Study. were high, moderate, average (FH2 FH1: at least two generations one...
To compare the efficacy and safety of iGlarLixi with insulin glargine 100 units/mL (iGlar) lixisenatide (Lixi), in Asian Pacific people suboptimally controlled type 2 diabetes (T2D) on metformin or without a second oral antihyperglycaemic drug (OAD).LixiLan-O-AP (NCT03798054) was 24-week multicentre study adults (n = 878, mean age 56.0 years, body mass index 26.0 kg/m2 ) glycated haemoglobin (HbA1c) levels ≥53 mmol/mol (7%) ≤97 (11%) OAD(s), randomized (2:2:1) to open-label once-daily...
To investigate the prevalence and associated risk factors of microalbuminuria, to explore relationship between albuminuria cardiovascular disease (CVD). A nationally representative sample 38,203 Chinese participants was categorized by different levels urinary albumin-to-creatinine ratio (ACR; 0 -10 mg/g, 10 -20 20 -30 30 -300 mg/g). The compared using a single ACR cut-off point sex-specific points. Factors with presence albuminuria, CVD were analyzed logistic regression. Prevalence as...
Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim this study to determine prevalence CVDs and risk factors Chinese impaired glucose regulation subjects.We used a multistage, stratified sampling method select subjects from general population aged 20 years older. Subjects underwent an oral tolerance test identify normal (NGT) including isolated fasting (i-IFG), (i-IGT), combined IFG/IGT diabetic mellitus (DM). A logistic regression analysis was...
Fatty acids affect insulin secretion of pancreatic beta-cells. Investigating gene expression profiles may help to characterize the underlying mechanism. INS-1 cells were cultured with palmitate (0, 50, and 200 microM) for up 44 d. Insulin expressions 8740 genes studied. We found that basal increased in exposed palmitate. The response glucose stimulation declined on d at microM In 50 exposure, was changed 11 99 2 134 159 44, respectively. Genes involved fatty acid oxidation up-regulated,...
The adherence of 44 clinical isolates Enterococcus faecalis, a common cause endocarditis, and 13 faecium to substrates six extracellular matrix (ECM) proteins was examined using 35S-labeled bacteria. One E. faecalis strain, isolated from patient with adhered collagen types I IV another strain laminin IV. However, most showed little ( < 5% added cells adhered) when grown at 37 degrees C regardless their source (endocarditis, urine or fecal sample). When 46 (but not in CO2 nutrient limited...
Whether insulin secretion and sensitivity in older Chinese differ from younger persons without diabetes has not been examined is unknown to us. Oral glucose tolerance test was performed a total of 32,245 history. Insulin estimated by Matsuda's index (Matsuda ISI), measured the insulinogenic index. The were compared among three age groups: 20–39 (the young), 40–59 middle), greater than or equal 60 years older). A higher proportion postchallenge hyperglycemia (PH), both prediabetes stage,...
Background and Aims Obesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified number of genetic loci associated with obesity. The aim this study to examine the contribution obesity-related genomic diabetes in Chinese population. Methods We successfully genotyped 18 single nucleotide polymorphisms among 5338 diabetic patients 4663 controls. Both individual joint effects these on quantitative glycemic traits (assessing β-cell function insulin...
Increased expression of pituitary tumor-transforming gene 1 (PTTG1) is expressed in many tumors and regulates tumor growth progression. However, the precise function PTTG1 tumorigenesis lung adenocarcinoma (LAC) not defined yet. Here, we examined human LAC tissues by immunohistochemical assay using a tissue microarray procedure. A loss-of-function experiment was carried out to investigate effects lentiviral vector-mediated shRNA (shPTTG1) on cell invasive potential lines (A549 LETPα-2),...
Pre-eclampsia is characterized by endothelial activation, which triggered placental factor(s). One such factor may be trophoblastic debris that shed into the maternal blood to become trapped against pulmonary endothelium. Phagocytosis of necrotic (NTD) induces cell activation with increased secretion interleukin-6 (IL-6) and transforming growth β1 (TGFβ1), induce systemic activation. In addition its effects on vascular smooth muscle, evidence suggests nifedipine also affect endothelium,...