A5026921814- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Phagocytosis and Immune Regulation
- Acute Kidney Injury Research
- Melanoma and MAPK Pathways
- Influenza Virus Research Studies
- Neonatal and fetal brain pathology
- Protein Tyrosine Phosphatases
- Peptidase Inhibition and Analysis
- Neonatal and Maternal Infections
- Trauma and Emergency Care Studies
- Bacterial Infections and Vaccines
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Liaoning Cancer Hospital & Institute
2024
Qingdao Municipal Hospital
2022-2023
Qingdao University
2022-2023
Dalian Medical University
2021-2022
The Sixth People's Hospital of Zhengzhou
2010
In this study, we aimed to reveal the resistance mechanism of hepatocellular carcinoma (HCC) cells sorafenib by exploring effect FNDC5 on sorafenib-induced ferroptosis in HCC cells. We compared expression level between sorafenib-resistant and sorafenib-sensitive cell lines groups after treatment with sorafenib. knocked down drug-resistant overexpressed it further demonstrate role ferroptosis. Using PI3K inhibitors, revealed specific which functions. addition, verified our findings obtained...
The purpose of this study was to investigate the effect FNDC5 expression levels in hepatocellular carcinoma on phenotypic changes macrophages tumor tissues. In study, we established an vitro co-culture system cells and macrophages. Then performed overexpression or knockdown gene observe level THP-1 And conclusions obtained assay were further validated by a subcutaneous tumorigenic nude mice model. Our findings suggest that elevated lead increased M2 phenotype decreased M1 This may be...
Background: The pseudouridine synthases (PUSs) have been reported to be associated with cancers. However, their involvement in hepatocellular carcinoma (HCC) has not well documented. Here, we assess the roles of PUSs HCC. Methods: RNA sequencing data TCGA-LIHC and LIRI-JP were downloaded from Cancer Genome Atlas (TCGA) International Consortium (ICGC), respectively. GSE36376 gene expression microarray was Gene Expression Omnibus (GEO). Proteomics for an HBV-related HCC cohort obtained CPTAC...
Abstract SUMOylation (SUMO modification) has been confirmed to play an essential role in the progression of various malignancies. As value SUMOylation-related genes (SRGs) prognosis prediction hepatocellular carcinoma (HCC) not explored, we aim construct HCC SRGs signature. RNA sequencing was utilized identify differentially expressed SRGs. The 87 identified were used Univariate Cox regression analysis and Least Absolute Shrinkage Selection Operator (LASSO) build a accuracy model validated...
The homeobox (HOX) gene family has been found to be involved in human cancers. However, its involvement hepatocellular carcinoma (HCC) not well documented. Here, we comprehensively evaluated the role of HOXs HCC.RNA sequencing profile TCGA-LIHC and LIRI-JP were obtained from Cancer Genome Atlas (TCGA) International Consortium (ICGC), respectively. Data methylation downloaded UCSC Xena. Genetic alteration data for TCGA samples was cBioPortal GSCA. diagnostic efficiency assessed using ROC...
High heterogeneity is an essential feature of malignant tumors. This study aims to reveal the drivers hepatocellular carcinoma for prognostic stratification and guide individualized treatment.
Objective To prospectively study the effects of different fluid resuscitation on kidney function in pediatric patients with sepsis. Methods One hundred and eighteen sepsis shock who needed Intensive Care Unit, Zhengzhou Children's Hospital from June 2012 to 2015 were selected, they randomly divided into group A, B C by random number table.The received hydroxyethyl starch, 50 g/L albumin 9 saline.After that, neutrophil gelatinase associated lipocalin (NGAL), α-1 microglobulin, urea...
Abstract SUMOylation (SUMO modification) has been confirmed to play an important role in the progression of various malignancies. As value SUMOylation-related genes (SRGs) prognosis prediction hepatocellular carcinoma (HCC) not explored, we aimed construct a HCC SRGs signature. RNA sequencing was utilized identify differentially expressed SRGs. The 87 identified were used Univariate Cox regression analysis and Least Absolute Shrinkage Selection Operator (LASSO) build signature prognostic...