A5028259145- Cancer Cells and Metastasis
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Celiac Disease Research and Management
- Organ Transplantation Techniques and Outcomes
- Kruppel-like factors research
- Signaling Pathways in Disease
- Mesenchymal stem cell research
- Anatomy and Medical Technology
- Esophageal Cancer Research and Treatment
- Enhanced Recovery After Surgery
- Inflammatory Biomarkers in Disease Prognosis
Shanghai Jiao Tong University
2024
Hua Medicine (China)
2023
Chongqing Medical University
2012-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012-2022
Second Affiliated Hospital of Nanchang University
2015-2021
Nanchang University
2015-2021
Shenzhen Children's Hospital
2021
St. Jude Children's Research Hospital
2017
Anhui Provincial Hospital
2013
Anhui Medical University
2012-2013
The aim of this study was to determine a role microRNA-21 (miR-21) in colorectal cancer (CRC) and elucidate the regulation phosphatase tensin homologue (PTEN) gene by miR-21. MiR-21 expression investigated 30 CRC samples five cell lines. In study, we show that miR-21 overexpressed compared with adenomas normal tissues. Patients poor differentiation, lymph node metastasis advanced TNM stage showed significantly high Inhibition HCT116 line reduced cellular proliferation, migration invasion,...
// Ren Zhao 1, * , Zhen Cai 2, Sheng Li 3, Yong Cheng 4 Hua Gao 5 Fang Liu 6 Shiyang Wu Suyan Yan Dong Lei Zheng 2 Wenbin Zhang 7 Xiaojun 8 Xueqing Yao 3 1 Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School Medicine, Shanghai, China Laboratory Sino-UK Circulating Biomarkers' Exploration and Detection Center, Nanfang Southern Medical University, Guangzhou, 3Department surgery, Guangdong Hospital & Academy Sciences, Gastrointestinal First Affiliated Chongqing...
Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone influence viability and poor prognosis neuroblastoma cells, where MYC is often overexpressed. We also identified approved small-molecule antifungal agent ciclopirox as a novel pan-histone demethylase inhibitor. Ciclopirox targeted several demethylases, KDM4B implicated in function. Accordingly, inhibited Myc signaling parallel with mitochondrial...
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) was identified as the stem cell marker of colon cancer cells (CSCs), which were considered main criminal initiation and reinitiation cancer.We intended to demonstrate further explain relationship between LGR5 in mice model patients.In our research, we used transcriptional methods immunohistochemistry investigate gene protein expression, examined proliferating nuclear antigen (PCNA) Ki67 classic markers for proliferation...
Purpose: Epithelial-mesenchymal transition (EMT) is crucial for tumor progression and metastasis. Snail family members, including Snail, Slug Smuc, are the transcription factors that repress E-cadherin expression induce epithelial-mesenchymal in some tissues. In this study, of snail proteins cervical squamous cancers was evaluated. Methods: A series 144 samples, comprising 28 cases normal tissues 116 cell carcinoma (SCC), were used analysis. The Slug, vimentin assessed by...
Circulating tumor DNA (ctDNA) enables genomic profiling of colorectal cancer. We investigated therapeutic targets by performing ctDNA panel-captured sequencing 152 blood samples from advanced stage patients, which somatic mutations and potentially actionable were evaluated. An additional 11 matched tissue retrospectively obtained to verify target validity. The mutation frequencies 1,127 collective genetic variants identified in our study strongly correlated with those multiple public...
The poor prognosis and fewer treatment option is a current clinical challenge for patients with lung adenosquamous carcinoma (ASC). previous studies reported that tumor mutational burden (TMB, numbers of mutation per Megabase) predictor response in trials multiple cancer types, while assessed the relationship between TMB level features outcomes ASC. Herein, present study enrolled Chinese DNA was extracted from formalin-fixed paraffin-embedded samples subjected to next generation sequencing...
BACKGROUND Numerous studies have shown that esophageal cancer (ESCA) contains areas of intertumoral hypoxia. It is widely accepted the association hypoxia with stemness in tumor microenvironment ESCA profound clinical significance. However, reliable prognostic signatures based on and are still lacking ESCA. MATERIAL AND METHODS The t-SNE algorithm was used to estimate status transcriptome profiles discovery cohort TCGA database. Median values index were group identify stemness-associated...
The purpose of the current study was to analyze influence radiological "disappearing liver metastasis" (DLM) on efficacy and prognosis patients with colorectal metastases (CRLM) undergoing conversion therapy.Patients CRLM by multidisciplinary team (MDT) First Affiliated Hospital Chongqing Medical University were retrospectively enrolled from January 2014 2021. relationship between occurrence recurrence DLM different clinical factors analyzed.Thirty-five 113 (31.0%) initially unresectable...
Abstract Co-targeting PD-1/PD-L1 and TIGIT/CD226 is being pursued to broaden the efficacy of current immunotherapy. Here we demonstrate that a bispecific antibody (BsAb) targeting PD-L1 TIGIT, HB0036, shows major advantages over combination two parental monoclonal Abs (mAbs). We demonstrated HB0036 co-engages + tumour cells TIGIT T cells, thereby upregulates CD226 on induces greater T-cell proliferative response compared antibodies in vitro . In vivo , recruits amounts tumours but not -...
F ar upstream sequence element (FUSE) binding proteins (FBPs) represent a novel group of factors that induce proliferation and migration in HCC cells. FBP-1 is multifunctional factor has been ascribed to various mRNA processing functions such as transcription, splicing, stabilization, transcript degradation. However, the underlying molecular mechanisms FBP-1-dependent effects human carcinogenesis are largely unknown. In an attempt identify relevant downstream effectors overexpression cells,...