A5044508950- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Synthesis of Organic Compounds
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Synthesis and biological activity
- Circular RNAs in diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Renal and related cancers
Rostov Research Institute of Oncology
2018-2022
Ministry of Health of the Russian Federation
2019-2021
Purpose of the study. To study local immunity and cytokine levels in colon cancer patients with subcompensated intestinal obstruction. Patients methods. In 60 locally advanced left-side carcinoma (30 30 without bowel obstruction) during surgery samples tumor, peritumoral area resection line tissue were obtained. After disintegration Т-, В-, NK-lymphocytes` subsets (CD3+, CD4+, CD8+, CD4+CD25+CD127dim, CD19+, CD16+CD56+) studied by flow cytometry inflammatory cytokines` content (TNF-α, IL-1α,...
Today, colorectal cancer (CRC) is the third most common and therefore an urgent problem of oncology. Despite all modern diagnostic capabilities, rates advanced cases are growing steadily. CRC was proven to be a result phased dysplastic change in colon mucosa, molecular genetic changes that determine biology tumor, its properties, morphology, disease prognosis response therapy. The following mechanisms tumor progression distinguished: chromosomal instability, microsatellite "methylator"...
Background. Currently, little is known about the specific microRNAs involved in development of cervical intraepithelial neoplasia (CIN1, 2, 3) and transition to cancer situ (CIS). Our meta-analysis allowed us isolate 8 (hsa-miR-1246, hsa-miR- 145-5p, hsa-miR-196b-5p, hsa-miR-34a-5p, hsa-miR-20a-5p, hsa-miR-21-5p, hsa-miR-375-5p, hsa-miR-96-5p) with potential significance progression precancerous diseases cancer. Objective: analyze expression features hsa-miR-1246, hsa-miR-145-5p,...
УДК 616-006.66ОСОБЕННОСТИ ЛОКАЛЬНОГО КЛЕТОЧНОГО ИММУНИТЕТА ПРИ РАКЕ ОБОДОЧНОЙ КИШКИ В ЗАВИСИМОСТИ ОТ ЛОКАЛИЗАЦИИ ОПУХОЛЕВОГО ПРОЦЕССА Кит О.И. 1 , Дженкова Е.А. Мирзоян Э.А. Сагакянц А
Purpose of the study. Evaluation expression immunohistochemical tumor markers Ki-67, b-catenin, Bcl-2, P53, connexin 32 and 43 when using 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in mice with xenographs squamous cell lung cancer. Materials methods . Subcutaneous PDX models human cancer were created immunodeficient BALB/c Nude mice. A fragment patient’s (3 × 3 mm) was implanted subcutaneously right thigh a previously anesthetized mouse. 200 μl administered...
Purpose of the study . To evaluate prognostic significance biological factors VEGF-A, sVEGF-R1, VEGF-D, FGF, EGF, EGFR, IGF-1, IGF-2, IGFBP-1, IGFBP-2, somatotropin-releasing factor (GHRH) in kidney tissues (tumour tissue, tissue perifocal zone and conditionally intact tissue) local generalized clear cell renal cancer using ROC analysis. Materials methods Two groups patients were included study. Group 1 comprised 50 with (T1–3N0M0), while group 2 metastatic (T1–4N0M1). 10% cytosolic...
УДК 616.34-006.6МИКРОРНК КАК МАРКЕРЫ ПРОГРЕССИРОВАНИЯ ПРЕДРАКОВЫХ ЗАБОЛЕВАНИЙ В РАК ШЕЙКИ МАТКИ Димитриади Т.А. 1 , Бурцев Д.В. Дженкова Е.А. 2 Кутилин Д
Purpose of the study . Assessment level certain cytokines in saliva patients with primary locally advanced cancer oral mucosa addition to surgical treatment intraoperative PDT (IPDT). Patients and methods. T3-4aN0-2M0 were divided into 2 groups: main group (30 patients) underwent radical tumor removal supplemented IPDT control without addition. was performed using Latus-T (farah) a chlorin E6 photosensitizer. Cytokine levels determined unstimulated whole day before, on 3rd 7th after...
ДИНАМИКА ЦИТОКИНОВОГО ПРОФИЛЯ КРОВИ БОЛЬНЫХ С МЕТАСТАТИЧЕСКИМ КОЛОРЕКТАЛЬНЫМ РАКОМ ПРИ ПРОВЕДЕНИИ анти-EGFR ТЕРАПИИКит О.И., Владимирова Л.Ю
Epidemiological data indicate high rates of morbidity and mortality oral mucosal cancer worldwide. At the same time, even visual accessibility does not allow detecting in early stages. The purpose study . Assessment involvement cytokines development progression cancer. Materials methods search for publications was carried out databases RSCI, PubMed, Scopus 2019-2023 years following queries: mucosa; potentially malignant diseases cavity; precancerous cavity, inflammation cancer, cytokines,...
Background . Among all the new methods and approaches, virotherapy with oncolytic viruses, both in combination immunotherapy without it, shows high efficiency various phases of clinical trials good tolerance by patients. Aim To study sensitivity some immortalized cancer cell lines to R-92 strain human reovirus characteristics at ultrastructural level. Materials The was carried out on HeLa, A549, U87MG. Cells were planted an amount 15 thousand per well a 96-well plate after adhesion, virus...
The last decade is characterized by significant progress in the treatment of rectal cancer (reduction number relapses to 5–6 % with use prolonged radiation therapy) before surgery. greatest success has been achieved lower ampulla rectum, when it possible develop a complete clinical response tumor chemoradiotherapy. Nevertheless, requirement issues improve results upper and middle ampullar rectum an increase survival patients remain. Which makes relevant new methods, that effectiveness...
Colorectal cancer remains in the leading positions structures of morbidity and mortality among both sexes. A large number studies are aimed to reveal new biomarkers targeted at early diagnosis improving effectiveness drug therapy. carcinoma (CC) is heterogeneous its morphological, molecular immunological aspects a disease. The existing genetic classifications capable predicting therapy aren’t optimal enough. New prognostic markers would make it possible identify subgroup patients with high...
Введение. Корректная оценка стадии и прогноза является основой успешного лечения любой опухоли. Цель — оценить роль ряда иммунологических параметров локального иммунитета при раке ободочной кишки (РОК) в зависимости от распространенности процесса на основании полученных данных разработать комплексную модель для определения вероятности лимфогенного метастазирования Материалы методы. В работу включено 50 пациентов РОК: c поражением лимфатических узлов (N+) 27 (54 %), без поражения (N0) 23...
Objective: to evaluate the eff ectiveness of regional cervical cancer screening program by liquid-based cytology. Materials and Methods: geography includes 54 medical units Rostov region, where patients are taken swabs from cervix. HPV positive with abnormal PAP smears invited Regional pathology center for diagnosis treatment. Methods. cytology, test RealTime PCR, colposcopy video recording, biopsy cervix method loop excision or electroradiographic conization. Results: From 2014 2017, 188...
ПОЛОВЫЕ РАЗЛИЧИЯ В СОДЕРЖАНИИ КОМПОНЕНТОВ ИНСУЛИНОПОДОБНОГО СИГНАЛЬНОГО ПУТИ ТКАНЯХ ПОЧКИ ПРИ ЛОКАЛЬНОМ И ГЕНЕРАЛИЗОВАННОМ СВЕТЛОКЛЕТОЧНОМ РАКЕ ПОЧКИБреус А
Purpose of the study . To evaluate number cells with CD45 +/- phenotype expressing Toll-like receptors (TLRs) in tissues tumor, peritumoral area and resection line colon cancer (CC) various tumor locations. Materials methods The included 50 patients CC. All underwent surgery as primary treatment, tissue material was collected from patients. Expression TLRs (2, 3, 4, 8, 9) on + , - cell populations determined by flow cytometry suspensions obtained (1–3 cm tumor) (~10 further calculation...
Purpose of the study . To determine quantitative parameters molecular markers Ki‑67 and p16/INK4a at CIN 1–3 to establish possibility using them improve quality diagnosis by histological samples. Patients methods. Biopsy material cervix was studied in 71 patients who were carriers HPV infection. Immunohistochemical method (IHC) biopsy specimens determined expression markers. Results According results a standard examination, distribution patientsinto groups occurred as follows: 1–18, 2–39,...
Background . Gastric cancer is the second leading cause of cancer-related death due to advanced disease. A special role in pathogenesis and metastasis tumor assigned stem cells (TSC ), responsible for resistance chemotherapy radiotherapy causing progression. Objective : determine CD 44 133 markers TSC tissues non-metastatic metastatic gastric using immunohistochemical method. Material Methods prospective study tumors patients with was conducted: Group 1 – 20 people T3–4aN0–3M0G2 tumor,...
The aim is to conduct a cardiometric assessment of formation acute and late toxic disorders in experimental animals with Guerin's carcinoma during carboplatin chemotherapy against the background L-carnitine medication
Risk factors, p53, bcl-2, Topo2α, E-cadgerin, androgen receptor's expression, estrodiol, estron, testosterone, progesterone, prolactin, estrogen methabolitis, sex-steroid connecting globulin, growth factors: VEGF, EGF, TGFß1, IGF1, IGF2, plasmin, plasminogen, u-PA, t-PA, PAI-1 levels in the tumor and perifocal tissue, population subpopulation structure of lymphocytes peripheral blood, ploidy cell cycle estimating among 850 patients with different biologic breast cancer subtypes were tested....
Aim. To study the clinical morphological and molecular genetic characteristics of clinically hereditary breast cancer with without verified mutation BRCA1, BRCA2 compared to sporadic cancer.
 Methods. The included 191 female patients stage I-IIA signs cancer. In order identify mutations in genes ВRCA1/2 analysis deoxyribonucleic acid from peripheral blood leukocytes was performed.
 Results. total frequency BRCA1 ВRCA2 amounted 14.1% number examined patients. most common among...
Introduction: The purpose of the study was to compare activity urokinase (uPA) and tissue (tPA) plasminogen activators content their proenzyme forms (pro-uPA, pro-tPA) in adenocarcinoma esophagus (EA), stomach (SA), pancreatic head (PHA), sigmoid colon (SCA) rectum (RA). Methods: Tissues tumors, perifocal area resection line tissues were studied by ELISA 143 patients (38-74 years) with EA (n=12, G2, T2-3N0-1M0), SA (n=28, PHA (n=46, T2-4N0M0), SCA (n=31, T2-3N0-1M0) RA (n=26, T2-3N0-1M0)....
e15534 Background: A metastatic niche indicates a particular location with specific cell type, epidermal-mesenchymal transition proteins and diffuse signals that are necessary for the growth of metastases. The purpose study was to determine levels VEGFs, their receptors TGFβ1 in tissues gastric cancer (GC) its niches: peritoneum omentum. Methods: main group included 21 patients GC T 3-4 а N 0-3 M 1 ; comparison – 17 non-cancer patients. Levels VEGFA, VEGFC, sVEGFR1, sVEGFR3 were determined...