A5005360946- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Multiple and Secondary Primary Cancers
- Circular RNAs in diseases
- Metastasis and carcinoma case studies
- Cancer Mechanisms and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Biliary and Gastrointestinal Fistulas
- Medical and Biological Sciences
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Liver Diseases and Immunity
- Glutathione Transferases and Polymorphisms
- Diverticular Disease and Complications
- Nutrition, Genetics, and Disease
- Heart Failure Treatment and Management
- Immune cells in cancer
Ministry of Health of the Russian Federation
2020-2023
Rostov Research Institute of Oncology
2014-2023
Russian Academy of Sciences
2022
Organic synthesis is a valuable source of promising antitumour drugs. The purpose this paper was to study the cytotoxic effect new tropolone derivative 2-(1,1-dimethyl-1H-benzo[e]indolin-2-yl)-5,6, 7-trichloro-1,3-tropolone (JO-122) on SW620 colon cancer cell line, compared with standard chemotherapy drug 5-fluorouracil. Materials and methods. research conducted permanent adenocarcinoma line SW620. Cytotoxic activity JO-122 determined in an experiment construction dose–response curve; number...
УДК 616-006.66ОСОБЕННОСТИ ЛОКАЛЬНОГО КЛЕТОЧНОГО ИММУНИТЕТА ПРИ РАКЕ ОБОДОЧНОЙ КИШКИ В ЗАВИСИМОСТИ ОТ ЛОКАЛИЗАЦИИ ОПУХОЛЕВОГО ПРОЦЕССА Кит О.И. 1 , Дженкова Е.А. Мирзоян Э.А. Сагакянц А
The WHO Classification of Digestive System Tumors (WHO, 5th Edition, 2019) presents new provisions on the morphological, molecular genetic, and therapeutic aspects hepatocellular carcinoma (HCC). This classification versus 2010 edition underwent substantial changes. Undifferentiated (ICD-0: 8020/3) was excluded. TNM staging system introduces additional gradations. Based evidence, HCC types subtypes (scirrhous, clear cell, steatohepatic, others) were identified depending gene mutations...
The modern concept of general carcinogenesis is built on the basic knowledge exogenous and endogenous factors. They change body–organ–cell homeostatic tissue basis lead to genetic molecular alterations followed by uncontrolled abnormal cell growth. We studied hepatocellular carcinoma (HCC) as an example malignant neoplasm carcinogenesis. article presents some major resulting in HCC well their association with immune microenvironment that mostly determines onset further tumor development....
СОДЕРЖАНИЕ ДОФАМИНА, НОРАДРЕНАЛИНА, СЕРОТОНИНА И 5-ОКСИИНДОЛУКСУСНОЙ КИСЛОТЫ В МОЧЕ БОЛЬНЫХ РАКОМ МОЧЕВОГО ПУЗЫРЯ ЗАВИСИМОСТИ ОТ НАЛИЧИЯ САХАРНОГО ДИАБЕТАГорошинская И.А
Purpose of the study. Was to investigate possibility applying method spheroid formation in culture for assessment endometrial cancer (EC) tumor stem cells (TSC) content complex samples containing various and microenvironment. Materials methods . Primary cultures were obtained from fragments tumors removed during surgery as a first stage treatment at Department Gynecological Oncology, National Medical Research Center Oncology. After enzymatic disaggregation tissue, cell suspension was...
Purpose of the study . To evaluate number cells with CD45 +/- phenotype expressing Toll-like receptors (TLRs) in tissues tumor, peritumoral area and resection line colon cancer (CC) various tumor locations. Materials methods The included 50 patients CC. All underwent surgery as primary treatment, tissue material was collected from patients. Expression TLRs (2, 3, 4, 8, 9) on + , - cell populations determined by flow cytometry suspensions obtained (1–3 cm tumor) (~10 further calculation...
Background . Gastric cancer is the second leading cause of cancer-related death due to advanced disease. A special role in pathogenesis and metastasis tumor assigned stem cells (TSC ), responsible for resistance chemotherapy radiotherapy causing progression. Objective : determine CD 44 133 markers TSC tissues non-metastatic metastatic gastric using immunohistochemical method. Material Methods prospective study tumors patients with was conducted: Group 1 – 20 people T3–4aN0–3M0G2 tumor,...
Purpose of the study: to analyze available data on combination radiation therapy with antiangiogenic drugs in treatment patients brain metastases. Material and methods. The search for relevant sources was carried out using Medline, Cochrane Library, Elibrary, PubMed databases concerning publications describing role results. To date, there are various options drugs. results obtained indicate that radiotherapy combined is more efficient metastases than used alone. Conclusion. Treatment remains...
Aim . To investigate the content of insulin-like growth factor (IGF)-1, IGF-2, and their transporter proteins IGFBP-1 IGFBP in liver rats with experimental diabetes, Guerin’s carcinoma, combination. Materials methods. The experiment was carried out on 64 white outbred both sexes, which were divided into 4 groups 8 animals each: group 1 – intact animals, 2 3 subcutaneously inoculated diabetes carcinoma. In study, biochemical statistical analyses enzyme immunoassays performed. Results rats,...
the purpose of study was to analyze facts and mechanisms development second malignancies after radiodiagnostic radiotherapy procedures as well different medicamental treatments. search for relevant articles published over last 6 years carried out using medline, elibrary, pubmed databases, 34 publications were included in this review. risk from ct scans radiation therapy is increased by 1.5–3 times cancer patients. some drugs treatment chronic non-oncology diseases many chemotherapeutic...
Taking into account cancer and diabetes comorbidity, the role of free radicals in these conditions dependence pathological processes on gender animals, aim study was to examine lipid peroxidation (LPO) intensity activity key antioxidant enzyme superoxide dismutase (SOD) heart, kidneys, liver, tumors male female rats with mellitus (DM), Guerin's carcinoma (GC) or both diseases. Materials Methods. The included 80 white nonlinear (180–220 g). animals were divided 4 groups, each group 10 (either...
Purpose of the study. Was to reveal characteristics immunocompetent cells in colon cancer (CC) according disease stage, and identify prognostic factors development. Materials methods . The study included 50 patients with CC: stage I – 4 (8 %), II 25 (50 III 21 (42 %). All underwent standard surgical intervention at initial obtained material was used for subsequent studies: a cell suspension from tumor tissue, peritumoral zone (1–3 cm tumor), which treated an antibody panel (Becton Dickinson,...
Purpose of the study. Was to reveal characteristics immunocompetent cells in colon cancer (CC) according disease stage, and identify prognostic factors development. Materials methods . The study included 50 patients with CC: stage I – 4 (8 %), II 25 (50 III 21 (42 %). All underwent standard surgical intervention at initial obtained material was used for subsequent studies: a cell suspension from tumor tissue, peritumoral zone (1–3 cm tumor), which treated an antibody panel (Becton Dickinson,...
Introduction. Colorectal cancer is a frequently diagnosed disease being in the third place among oncological diseases both incidence and mortality. Currently, researchers focus on development of more accessible reliable biomarkers colorectal to overcome problems diagnosis progression prognosis this pathology. Aim. To investigate characteristics microRNA expression circulating tumor cells (CTC) patients with cancer. Materials methods. The study included blood samples from 299 colon cancer,...