A5058123271- Cervical Cancer and HPV Research
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Glycosylation and Glycoproteins Research
- Endometrial and Cervical Cancer Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Electrolyte and hormonal disorders
- Chronic Lymphocytic Leukemia Research
- Sepsis Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Neonatal Health and Biochemistry
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Multiple and Secondary Primary Cancers
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
Rostov Research Institute of Oncology
2017-2022
Ministry of Health of the Russian Federation
2021
e17505 Background: The purpose of the study was to determine VEGF-A expression in patients with cervical cancer assess its prognostic value. Methods: included 82 (23-70 years, median age 50.5±1.3 years) who underwent surgery for (T1aNоMo – 23 patients, T1bNоMo 42, T2aNоMo 17). VEGF-А determined blood serum before and after (Elisa, Chem Well, USA). results were compared clinical morphological data. control group 18 healthy women similar distribution. Results: Levels controls did not exceed...
Purpose of the study . Analysis possibility using presepsin in early diagnosis sepsis cancer patients after extensive surgical interventions for tumors thoraco-abdominal localization. Materials and methods The included 27 people: 10 healthy individuals (control) 17 who received treatment at National Medical Research Center Oncology malignant neoplasms In blood all patients, studies markers were performed: (P-SEP), highly sensitive CRP (hsCRP) (PATHFAST, Japan), procalcitonin (PCT),...
Cancer is one of the leading causes death and disability worldwide. Timely diagnosis introduction new effective treatments, including intensive radiation chemotherapy regimens, have significantly improved survival forecasts in recent years. At same time, use these types treatment increases risk complications, which includes chemotoxic cardiopathies. In this regard, timely detection complications from cardiovascular system patients receiving courses combination with surgical methods...
e17018 Background: The purpose of the study was to analyze effect HPV/Chlamydia trachomatis co-infection on hormonal status tumor and visually unchanged cervical tissues in cancer patients. Methods: We studied levels estrone (E1), estradiol (E2), free estriol (E3), (fT) total (T) testosterone, progesterone (P4) prolactin (PRL) by ELISA tumors 49 patients with T1b-2aN0M0 endophytic (25 patients) exophytic (24 patterns growth. 13 12 ones were infected HPV Сhlamydia (Ch.tr.). infection...
e17019 Background: The purpose of the study was to analyze hormonal disorders in tissues histologically unchanged ovaries patients with cervical cancer infected HPV/Chlamydia trachomatis. Methods: We studied levels estrone (E1), estradiol (E2), free estriol (E3), (fT) and total (T) testosterone, progesterone (P4), steroid-binding globulin (SBG) prolactin (PRL) by ELISA intact 25 aged 53.4±3.2 years T1b-2aN0M0. HPV presence determined Е7 protein expression, Chlamydia trachomatis (Ch. tr.) –...
e17020 Background: The role of Chlamydia trachomatis (Ch. tr.) in development cervical neoplasia is widely discussed. However, molecular mechanisms Ch. tr. contribution to carcinogenesis are poorly studied. purpose the study was analyze degrees DNA damage blood leucocytes patients with cancer infection and non-infected healthy women. Methods: assessed by comet assay, alkaline single-cell gel electrophoresis (20 min, 300 mA, 20 V, 2 V/cm, 4°C) allowing detection base modifications leading...
e22007 Background: The purpose of the study was to analyze phenotypic characteristics red blood cells by AVBO, Rh and Kell systems in children with cancer. Methods: ABO groups were determined erythrocyte antigens (D, С, с, С w , Е, е, К, k) typed (AutoVue Innova, USA) samples 114 solid tumors. Results: distribution as follows: A(II) > O(I) B(III) AB(IV) prevalence. Rh(D)-positive phenotype observed 82 (71.9%) patients 114: 47 (57.3%) boys 35 (42.6%) girls. 32 (28.1%) Rh(D)-negative: 15...
e19510 Background: The purpose of the study was to analyze changes in reticulocytic indices and their role assessing effectiveness erythropoiesis patients with multiple myeloma. Methods: Thestudy included 10 primary myeloma (MM) 16 recurrent MM, stage II-III. Parameters peripheral blood were studied: Hb, RBC, MCV, MCH, RBC-He (red cell hemoglobin content), RET (number percentage), IRF (immature reticulocyte fraction), high (HFR), median (MFR) low (LFR) fluorescence reticulocytes, RET-He...
e19511 Background: Our purpose was to analyze levels and types of paraprotein in polychemotherapy combined with selective plasma exchange patients multiple myeloma. Methods: Blood (PP) were studied by capillary electrophoresis (Helena Bioscience V8), content cells determined the bone marrow 16 (main group) myeloma (MM) during (PCT) plus (SPE). 14 receiving standard PCT controls. Results: MM both groups characterized presence PP blood serum M-peak gamma-globulin zone. Only heavy IgG chains...
e17579 Background: Our purpose was to evaluate changes in blood parameters patients with laryngeal squamous cell carcinoma (LSCC) during polychemotherapy (PCT) cetuximab. Methods: Levels of white cells (WBC), immature granulocytes (IG) and neutrophils (Ne), as well levels C-reactive protein (CRP), lactate dehydrogenase (LDH) creatinine were studied the 20 stage I-III LSCC before therapy cetuximab/cisplatin+5-fluorouracil on days 2, 9 16 therapy. The control group (21 patients) received...
e14508 Background: We monitored the level of methotrexate and some laboratory parameters in patients with osteosarcoma to evaluate toxicity high-dosage EURAMOS chemotherapy. Methods: The study included 5 aged 10-17 years receiving chemotherapy high-dose (12 g/m2) (MTX). Plasma levels MTX were determined (VIVA E, Netherlands) before administration 4, 24, 36, 42, 48, 54, 60, 66 72 hours. Were investigated C-reactive protein velocity (CRPv), α1-antitrypsin (AAT), urea, creatinine, N-terminal...
e24327 Background: The purpose of the study was to analyze phenotypic profile erythrocytes in Rhesus and Kell systems patients with malignant benign tumors. Methods: Phenotyping by D, C, c, Cw, E, e, K, k с antigens performed gel technology (Auto Vue Innova system, USA) 147 patients: acute lymphoblastic leukemia (ALL) – 26 (17.6%) patients, cancer - 39 (26.5%), lymphoma 18 (12.2%), sarcoma 25 (17%), neuroblastoma 15 (10.2%), tumors 24 (16.3%). Results: Rh (D) positive phenotype found 106...
e19554 Background: The purpose of this study was to assess NT-proBNP as a marker renal dysfunction in patients with diffuse large B-cell lymphoma receiving immune polychemotherapy. Methods: involved 24 aged 23-69 years (median 57 years) primary diagnosis (DLBCL). status assessed by the blood serum levels creatinine, urea, (Vitros 5600, USA), sodium (Cobas b221, Switzerland) calculation glomerular filtration rate (GFR) according CKD-EPI formula, well urine albumin Integra 400 plus,...
e19520 Background: The purpose of this study was to compare morphological and immunophenotypic characteristics the tumor population B-lymphocytes with varying restrictions immunoglobulin light chains in patients chronic lymphocytic leukemia (CLL). Methods: We examined 30 CLL (median age 64.9±8.6 years). All underwent CBC+DIFF blood tests (Sysmex XE 2100, Japan), examinations (BioVision; Micros, Austria), immunophenotyping (IPT) by multicolor flow cytometry (Navios 10/3, Beckman Coulter, USA)...
Cancer is one of the leading causes death and disability worldwide. Timely diagnosis introduction new effective treatments, including intensive radiation chemotherapy regimens, have significantly improved survival forecasts in recent years. At same time, use these types treatment increases risk complications, which includes chemotoxic cardiopathies. In this regard, timely detection complications from cardiovascular system patients receiving courses combination with surgical methods...