A5073691705- Differential Equations and Numerical Methods
- Advanced Mathematical Modeling in Engineering
- Advanced Numerical Methods in Computational Mathematics
- Cancer Treatment and Pharmacology
- Blood groups and transfusion
- Material Science and Thermodynamics
- Differential Equations and Boundary Problems
- Erythrocyte Function and Pathophysiology
- Cervical Cancer and HPV Research
- Monoclonal and Polyclonal Antibodies Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Numerical methods for differential equations
- Lymphoma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Bone health and treatments
- Glycosylation and Glycoproteins Research
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Electrolyte and hormonal disorders
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Cancer-related molecular mechanisms research
Rostov Research Institute of Oncology
2016-2022
Ural Branch of the Russian Academy of Sciences
2001-2021
N.N. Krasovskii Institute of Mathematics and Mechanics of the Ural Branch of the Russian Academy of Sciences
1999-2021
e17505 Background: The purpose of the study was to determine VEGF-A expression in patients with cervical cancer assess its prognostic value. Methods: included 82 (23-70 years, median age 50.5±1.3 years) who underwent surgery for (T1aNоMo – 23 patients, T1bNоMo 42, T2aNоMo 17). VEGF-А determined blood serum before and after (Elisa, Chem Well, USA). results were compared clinical morphological data. control group 18 healthy women similar distribution. Results: Levels controls did not exceed...
e19500 Background: The purpose of the study was to assess clinical significance level and type secreted paraprotein in blood serum patients with multiple myeloma. Methods: Concentration (PP) were studied by capillary electrophoresis (Helena Bioscience V8, UK) 25 aged 47-76 years myeloma (MM) before during polychemotherapy (PCT). Results: Monoclonal PP detected 22 (88%), while secretion absent 3 patients, along noted decrease gamma globulin levels presence plasma cells aberrant...
e17018 Background: The purpose of the study was to analyze effect HPV/Chlamydia trachomatis co-infection on hormonal status tumor and visually unchanged cervical tissues in cancer patients. Methods: We studied levels estrone (E1), estradiol (E2), free estriol (E3), (fT) total (T) testosterone, progesterone (P4) prolactin (PRL) by ELISA tumors 49 patients with T1b-2aN0M0 endophytic (25 patients) exophytic (24 patterns growth. 13 12 ones were infected HPV Сhlamydia (Ch.tr.). infection...
e17019 Background: The purpose of the study was to analyze hormonal disorders in tissues histologically unchanged ovaries patients with cervical cancer infected HPV/Chlamydia trachomatis. Methods: We studied levels estrone (E1), estradiol (E2), free estriol (E3), (fT) and total (T) testosterone, progesterone (P4), steroid-binding globulin (SBG) prolactin (PRL) by ELISA intact 25 aged 53.4±3.2 years T1b-2aN0M0. HPV presence determined Е7 protein expression, Chlamydia trachomatis (Ch. tr.) –...
e17020 Background: The role of Chlamydia trachomatis (Ch. tr.) in development cervical neoplasia is widely discussed. However, molecular mechanisms Ch. tr. contribution to carcinogenesis are poorly studied. purpose the study was analyze degrees DNA damage blood leucocytes patients with cancer infection and non-infected healthy women. Methods: assessed by comet assay, alkaline single-cell gel electrophoresis (20 min, 300 mA, 20 V, 2 V/cm, 4°C) allowing detection base modifications leading...
e22007 Background: The purpose of the study was to analyze phenotypic characteristics red blood cells by AVBO, Rh and Kell systems in children with cancer. Methods: ABO groups were determined erythrocyte antigens (D, С, с, С w , Е, е, К, k) typed (AutoVue Innova, USA) samples 114 solid tumors. Results: distribution as follows: A(II) > O(I) B(III) AB(IV) prevalence. Rh(D)-positive phenotype observed 82 (71.9%) patients 114: 47 (57.3%) boys 35 (42.6%) girls. 32 (28.1%) Rh(D)-negative: 15...
e19510 Background: The purpose of the study was to analyze changes in reticulocytic indices and their role assessing effectiveness erythropoiesis patients with multiple myeloma. Methods: Thestudy included 10 primary myeloma (MM) 16 recurrent MM, stage II-III. Parameters peripheral blood were studied: Hb, RBC, MCV, MCH, RBC-He (red cell hemoglobin content), RET (number percentage), IRF (immature reticulocyte fraction), high (HFR), median (MFR) low (LFR) fluorescence reticulocytes, RET-He...
e19511 Background: Our purpose was to analyze levels and types of paraprotein in polychemotherapy combined with selective plasma exchange patients multiple myeloma. Methods: Blood (PP) were studied by capillary electrophoresis (Helena Bioscience V8), content cells determined the bone marrow 16 (main group) myeloma (MM) during (PCT) plus (SPE). 14 receiving standard PCT controls. Results: MM both groups characterized presence PP blood serum M-peak gamma-globulin zone. Only heavy IgG chains...
e17579 Background: Our purpose was to evaluate changes in blood parameters patients with laryngeal squamous cell carcinoma (LSCC) during polychemotherapy (PCT) cetuximab. Methods: Levels of white cells (WBC), immature granulocytes (IG) and neutrophils (Ne), as well levels C-reactive protein (CRP), lactate dehydrogenase (LDH) creatinine were studied the 20 stage I-III LSCC before therapy cetuximab/cisplatin+5-fluorouracil on days 2, 9 16 therapy. The control group (21 patients) received...
e14508 Background: We monitored the level of methotrexate and some laboratory parameters in patients with osteosarcoma to evaluate toxicity high-dosage EURAMOS chemotherapy. Methods: The study included 5 aged 10-17 years receiving chemotherapy high-dose (12 g/m2) (MTX). Plasma levels MTX were determined (VIVA E, Netherlands) before administration 4, 24, 36, 42, 48, 54, 60, 66 72 hours. Were investigated C-reactive protein velocity (CRPv), α1-antitrypsin (AAT), urea, creatinine, N-terminal...
e24327 Background: The purpose of the study was to analyze phenotypic profile erythrocytes in Rhesus and Kell systems patients with malignant benign tumors. Methods: Phenotyping by D, C, c, Cw, E, e, K, k с antigens performed gel technology (Auto Vue Innova system, USA) 147 patients: acute lymphoblastic leukemia (ALL) – 26 (17.6%) patients, cancer - 39 (26.5%), lymphoma 18 (12.2%), sarcoma 25 (17%), neuroblastoma 15 (10.2%), tumors 24 (16.3%). Results: Rh (D) positive phenotype found 106...
e14505 Background: We monitored some biochemical parameters to assess hepatotoxicity of anthracycline chemotherapy in patients with breast cancer. Methods: The study included 30 (32-72 years, median age 52.0±12.8 years) st. II-III cancer receiving 4 cycles (AC) (CT). Serum levels total protein, albumin, bilirubin and its fractions, alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase, C-reactive protein (CRP), alpha-1 antitrypsin (A1AT) (Vitros 5600, USA) lactate...
e14506 Background: The purpose of the study was to assess changes in biochemical markers cardiotoxicity anthracycline chemotherapy for breast cancer. Methods: included 30 pts (32-72 years, 50%<50 years) with stage II-III cancer (BC) receiving 4 cycles (AC) (CT). N-terminal pro-brain natriuretic peptide (NT-proBNP), troponin I (TI), creatine kinase (CK), creatinine and urea were determined (Vitros 5600, USA) blood serum before AC administration on days 2 5 after it. results compared...
e13510 Background: The high rates of mortality from venous thromboembolism (VTE) in neurooncological patients determine the relevance topic. risk VTE with glioma reaches 36% during treatment period, 16.1% first 6 months and increases by 3 times after tumor biopsy. aim this study was to evaluate efficacy safety fondaparinux surgical interventions for brain tumors. Methods: included 32 cancer aged 27 76 years (mean 56.5 years) acute period VTE, month craniotomy. Creatinine clearance below 30...
e23513 Background: The purpose of the study was to reveal levels biochemical parameters for assessing intensity bone metabolism in patients with primary and metastatic tumors. Methods: included 29 aged 55.9±12.17 years (group 1, n = 12) 2, 17) Group 2 breast cancer (2a, 10) renal (2b, 7) a history pathological fractures. Serum turnover marker osteocalcin, TSH, resorption β-Cross Laps (C-terminal telopeptide) (Cobas e411, Japan) calcium (Vitros 5600, USA) were measured before after (day 14)...
e20086 Background: The purpose of the study was to analyze changes in erythron peripheral component during chemotherapy for malignant lymphomas patients infected with parvovirus B19 (B19V). Methods: included 34 (48.7±4.3 years). B19V infection determined by presence IgM/IgG antibodies blood serum and DNA plasma bone marrow before (CT). Parameters - RBC, HGB, MCW, MCH, MCHC, RDW, PLT, RET (#), IRF, LFR, MFR, HFR (%), myelogram were evaluated after CT (Sysmex XE 2100, Japan). Results: 82.5%...
e19554 Background: The purpose of this study was to assess NT-proBNP as a marker renal dysfunction in patients with diffuse large B-cell lymphoma receiving immune polychemotherapy. Methods: involved 24 aged 23-69 years (median 57 years) primary diagnosis (DLBCL). status assessed by the blood serum levels creatinine, urea, (Vitros 5600, USA), sodium (Cobas b221, Switzerland) calculation glomerular filtration rate (GFR) according CKD-EPI formula, well urine albumin Integra 400 plus,...
e19520 Background: The purpose of this study was to compare morphological and immunophenotypic characteristics the tumor population B-lymphocytes with varying restrictions immunoglobulin light chains in patients chronic lymphocytic leukemia (CLL). Methods: We examined 30 CLL (median age 64.9±8.6 years). All underwent CBC+DIFF blood tests (Sysmex XE 2100, Japan), examinations (BioVision; Micros, Austria), immunophenotyping (IPT) by multicolor flow cytometry (Navios 10/3, Beckman Coulter, USA)...