A5043327750- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Cardiac electrophysiology and arrhythmias
- Ear and Head Tumors
- Ion channel regulation and function
- Sarcoma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Hematological disorders and diagnostics
- Heart Rate Variability and Autonomic Control
Ministry of Health of the Russian Federation
2024
Rostov Research Institute of Oncology
2022
Purpose of the study . To examine influence specific factors on apoptosis process in mitochondria cells located various regions colon, with a focus patients both sexes. Patients and methods The included results obtained from 132 T2–3N0M0 colon cancer, comprising 52 women 80 men. Mitochondria were isolated human intestinal tumor tissue using differential centrifugation. concentration cytochrome C (ng/mg protein), AIF (pg/mg Bcl-2 calcium (mM/mg protein) determined. Results In men, level...
Purpose of the study. Preclinical study in experiment antitumor efficacy a new substance synthesized on basis pyrimidin-4-one derivative. Materials and methods. The sodium salt 4-{2-[2-[2-(4-hydroxy-3-methoxyphenyl)-vinyl]-6-ethyl-4-oxo-5-phenyl-4H-pyrimidin-1-yl}-benzsulfamide, inhibitor internal domain epidermal growth factor receptor (EGFR), was used this All C57BL6 mice both sexes were subcutaneously transplanted with B16/F10 melanoma. Twenty-four hours after tumor transplantation, main...
Experimental and clinical studies demonstrate the possibility of modulating development malignant tumors in thyroid imbalance, particular hyperthyroidism, which negatively affects electrophysiology heart. In an experimental model tumor growth during activation was shown. Aim: To study electrophysiological parameters mouse heart at initial stages transplantable hyperthyroidism. Material Methods. female mice C57BL/6 line (n = 20) created a melanoma B16/F10 induced by daily intraperitoneal...
11556 Background: Tumor necrosis factor alpha (TNFa) and its receptor (TNFa-R) play an important role in tumor genesis. However, their involvement the recurrence of sarcomas is poorly studied. The purpose this study was to analyze levels TNFa TNFa-R blood patients with recurrent soft tissue sarcomas. Methods: included 64 male female patients, mean age 63.4±5.2 years. Main groups G1 G3 T2bN0M0; comparison primary T2bN0M0. 95% tumors were liposarcomas, solitary rhabdamyosarcomas,...