A5059138572- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Peatlands and Wetlands Ecology
- Head and Neck Surgical Oncology
- Pelvic and Acetabular Injuries
- Body Contouring and Surgery
- Breast Cancer Treatment Studies
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- Hip and Femur Fractures
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Botany and Plant Ecology Studies
- Constructed Wetlands for Wastewater Treatment
Temple University
2018-2022
Philadelphia University
2018-2022
Fox Chase Cancer Center
2022
National Institutes of Health
2022
American College of Surgeons
2022
Abstract Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset non-small tumors upon progression, and drives NSCLC metastasis. We evaluated mechanism MSI2 action to gain therapeutically useful insights. Reverse phase array (RPPA) analysis MSI2-depleted versus control Kras LA1/+ ; Trp53 R172HΔG/+ lines identified EGFR as MSI2-regulated protein. expression activity an line panel was studied using...
Head and neck free flaps remain associated with considerable rates of take-back prolonged hospital length stay. However, there have been no studies on a national level benchmarking the timeline predictors head flap take-back.Patients undergoing reconstruction from American College Surgeons National Surgical Quality Improvement Program 2012-2019 database were analyzed to determine take-back. Timing unplanned take-backs stratified by tissue type postoperative day (POD) over first month....
Abstract Musashi-2 (MSI2) is an RNA-binding protein that regulates mRNA translation. We recently established MSI2 elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression and drives NSCLC metastasis, part based on activity supporting TGF-beta/SMAD3/claudin signaling cascade. Here, reverse phase array (RPPA) analysis MSI2-depleted versus control KrasLA1/+;P53R172HΔG/+ murine lines identified significant ~2.7-fold upregulation HER3 (ERBB3) depletion. Negative...
Background Abdominoplasty complication rates are among the highest for cosmetic surgery. We sought to create a validated scoring system predict likelihood of wound complications after abdominoplasty using national multi-institutional database. Methods Patients who underwent in American College Surgeons National Surgical Quality Improvement Program 2007–2019 database were analyzed surgical site complications, composite outcome disruption, and infections. The cohort was randomly divided into...