A5025436392- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Porphyrin and Phthalocyanine Chemistry
- Photochromic and Fluorescence Chemistry
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
- Antioxidant Activity and Oxidative Stress
- Nerve injury and regeneration
- Physiological and biochemical adaptations
- Cancer, Hypoxia, and Metabolism
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- bioluminescence and chemiluminescence research
- Circadian rhythm and melatonin
- Lipid Membrane Structure and Behavior
- Skin Protection and Aging
- Photoacoustic and Ultrasonic Imaging
- Retinoids in leukemia and cellular processes
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Spaceflight effects on biology
- Bioactive Compounds and Antitumor Agents
Southern Federal University
2012-2021
Norwegian Cancer Society
2002-2007
Institute of Physiologically Active Compounds
1997
Photodynamic therapy (PDT), in which stained cells are damaged by light the presence of oxygen, is now widely used for tumor destruction. Photogenerated singlet oxygen and reactive species cause oxidative stress cell death. The potential ROS sensors following intracellular processes leading to death considered. mode (necrosis or apoptosis) shown be controlled not only PDT parameters (irradiation intensity, photosensitizer localization its concentration) but also signal transduction...
Epigenetic processes play a critical role in melanoma development. However, little is known about proteins responsible for epigenetic transformations cells. The the peritumoral skin within excision margin are almost unstudied. We studied changes expression of 112 involved regulation gene human cutaneous and its zone using "The Proteomic Antibody Microarrays" (GRAA2, Sigma-Aldrich). Dimethylated histone H3 at lysines 4 9 as well transcription (histone deacetylases HDAC-1 HDAC-11, DNA...
Abstract To investigate the mechanisms of oxidative injury neurons and glia, we studied photodynamic effect on isolated stretch receptor that consists only two sensory enwrapped by satellite glial cells. Photodynamic therapy (PDT), a potent inducer stress, is prospective method for destruction brain tumors. PDT induced functional inactivation necrosis neurons, necrosis, apoptosis, proliferation The roles calmodulin, calmodulin‐dependent kinase II, phospholipase C, protein kinases A...
Hypericin is a promising photosensitizer for photodynamic therapy (PDT) characterized by high yield of singlet oxygen. Photobleaching hypericin has been studied means absorption and fluorescence spectroscopy in different biological systems: human serum albumin solution, cultured adenocarcinoma WiDr cells the skin nude mice. Prolonged exposure to light (up 95 min, 100 mW/cm2) wavelength around 596 nm induced fluence-dependent photobleaching all systems. The was not oxygen dependent, probably...
To study the mechanism of photodynamic nerve cell killing, isolated crayfish mechanoreceptor neurons were photosensitized by sulfonated aluminum ophthalocyanine Photosens. Neuron activity was continuously recorded until irreversible abolition. Intense (10−5M Photosens) or weak (10−7M photosensitization induced different bioelectric neuron responses: firing activation followed depolarization block gradual inhibition abolition, respectively. These responses accompanied biochemical and...
Abstract Neuroglial interactions are most profound during development or damage of nerve tissue. We studied the responses crayfish stretch receptor neurons (SRN) and satellite glial cells to photosensitization with sulfonated aluminum phthalocyanine Photosens. Although Photosens was localized mainly in envelope, were very sensitive photodynamic treatment. Photosensitization gradually inhibited then abolished neuron activity. Neuronal nuclei shrank. Some lost integrity plasma membrane died...