A5091236317- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Cervical Cancer and HPV Research
- Biotin and Related Studies
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- Molecular Biology Techniques and Applications
Ministry of Health of the Russian Federation
2019-2024
Ministry of Health
2024
Tomsk National Research Medical Center
2022
Russian Cancer Research Center NN Blokhin
2021
EVs are involved in local and distant intercellular communication play a vital role cancer development. Since have been found almost all body fluids, there currently active attempts for their application liquid diagnostics. Blood is the most commonly used source of screening markers, although percentage tumor-derived blood extremely low. In contrast, GJ, as biofluid, expected to be enriched with GC-associated EVs. However, from GJ never applied underinvestigated overall. Here we show that...
Introduction. The identification of markers for liquid diagnostics ovarian cancer is one the most urgent tasks gynecologic oncology. Currently, extracellular vesicles (EVs) are great interest as a source oncomarkers, including miRNA markers. We have previously shown that levels miR-125a-5p, -27a-5p, -193a-5p and 135b-5p significantly elevated miR-451a, -495-3p -136-5p decreased in EVs from uterine aspirates patients. Aim. Analysis -193a-5p, 135b-5p, 451a, 495-3p cell cultures secreted EVs....
Introduction . Human papillomavirus (HPV) infection with high-risk HPVs is an etiological factor in the development of cervical cancer, HPV type 16 (HPV16) being most common. The mechanisms leading to disruption viral oncogene expression and initiation epithelial cell transformation are poorly understood. Epigenetic regulatory factors, including cellular miRNAs, may play important role HPV-induced carcinogenesis, aberrantly expressed miRNAs be promising markers for diagnosis HPV-associated...
Background. Cervical cancer (CC) is the fourth leading cause of cancer-related morbidity and mortality among women. Despite established etiologic factor cervical cancer, especially high-risk human papillomavirus (HPV, papillomavirus) available vaccine prophylaxis, issue persists both in understanding mechanism HPV-associated carcinogenesis developing new approaches for diagnosis treatment cancer. Epigenetic regulation gene expression by means microRNAs plays an important role pathogenesis...
Introduction. High carcinogenic-risk human papillomaviruses (hrHPVs) are recognized as etiological agents of cervical cancer. Constant expression the viral oncoproteins, E6 and E7, is required for maintenance malignant phenotype tumor cells. The exact mechanism regulation oncogenes in cells not fully elucidated.
 purpose: identification noncoding RNAs (ncRNAs) HPV16-positve cancer.
 Materials methods. reverse transcription polymerase chain reactions were used to detect ncRNAs...
Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare epithelial tumors that arise from cells with neuroendocrine phenotype. NENs found in the gastrointestinal tract and pancreas – 60 % all localities. The incidence gastric is about 9 0.3 stomach tumors. Stomach (NETs) classified into three clinico-pathological types, based on etiology, pathogenesis morphology. There also separate cancers: small- large-cell. prognosis approach to treatment various types differs significantly....
Resistance of tumor cells to retinoic acid (RA), a promising therapeutic agent, is the major factor limiting use RA in clinical practice. The mechanisms resistance are still poorly understood. Cellular Retinoic Acid Binding Proteins, CRABP1 and CRABP2, essential mediators signaling, but role two CRABP homologs regulating cellular sensitivity has not been well studied. In addition, effects CRABP2 on cell proliferation have compared. Here, using broad panel breast cancer lines with different...