A5059251487- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Medical and Biological Sciences
- SARS-CoV-2 and COVID-19 Research
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Mesenchymal stem cell research
- Erythropoietin and Anemia Treatment
- Animal Virus Infections Studies
- Graphene and Nanomaterials Applications
- Collagen: Extraction and Characterization
- Spine and Intervertebral Disc Pathology
- Electrospun Nanofibers in Biomedical Applications
- Bone and Dental Protein Studies
- biodegradable polymer synthesis and properties
- Protein purification and stability
- Viral Infectious Diseases and Gene Expression in Insects
- Vector-borne infectious diseases
- T-cell and Retrovirus Studies
- Bacteriophages and microbial interactions
- Silk-based biomaterials and applications
Ministry of Health of the Russian Federation
2014-2023
Gamalei Institute of Epidemiology and Microbiology
2016-2023
All-Russian Scientific Research Institute of Food Biotechnology
2020-2023
Russian Academy of Sciences
2014-2022
National University of Science and Technology
2022
Center for Disease Control
2020-2021
Center for Strategic Research
2021
Academy of Medical Sciences
2014
Applied Nanotech (United States)
2013
Freie Universität Berlin
1992
E protein of tick-borne encephalitis virus (TBEV) and other flaviviruses is located on the surface viral particle. Domain III this seems to be a promising component subunit vaccines for prophylaxis TBE kits diagnostics TBEV.Three variants recombinant TBEV domain European, Siberian Far Eastern subtypes fused with dextran-binding Leuconostoc citreum KM20 were expressed in E. coli purified. The native structure was confirmed by ELISA antibody kit sera patients encephalitis. Immunogenic...
High efficiency of hybrid implants based on calcium-magnesium silicate ceramic, diopside, as a carrier recombinant BMP-2 and xenogenic demineralized bone matrix (DBM) scaffold for tissue regeneration was demonstrated previously using the model critical size cranial defects in mice. In order to investigate possibility these growing autologous vivo bioreactor principle patient's own body, effectiveness ectopic osteogenesis induced by them intramuscular implantation mice studied. At dose 7 μg...
A new platform for creating anti-coronavirus epitope vaccines has been developed. Two loop-like epitopes with lengths of 22 and 42 amino acid residues were selected from the receptor-binding motif Spike protein SARS-CoV-2 virus that participate in a large number protein-protein interactions complexes ACE2 neutralizing antibodies. types hybrid proteins, including one two epitopes, constructed. To fix conformation an approach using scaffolds was used. The homologue Rop Escherichia coli ColE1...
Based on the previously developed approach, hybrid recombinant proteins containing short conformational epitopes (a.a. 144-153, 337-346, 414-425, 496-507) of receptor-binding domain (RBD) SARS-CoV-2 Spike protein (S protein) were synthesized in Escherichia coli cells as potential components epitope vaccines. Selected are involved protein-protein interactions S complexes with neutralizing antibodies and ACE2 (angiotensin-converting enzyme 2). The used for immunization mice (three doses 2-week...