A5052597523- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Collagen: Extraction and Characterization
- Corneal Surgery and Treatments
- Periodontal Regeneration and Treatments
- Ocular Surface and Contact Lens
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Corneal surgery and disorders
- Cellular Mechanics and Interactions
- Orthopaedic implants and arthroplasty
- Engineering Technology and Methodologies
- Anatomy and Medical Technology
- Angiogenesis and VEGF in Cancer
- Developmental Biology and Gene Regulation
- Ocular Disorders and Treatments
- Craniofacial Disorders and Treatments
- Planetary Science and Exploration
- Mesenchymal stem cell research
- Spaceflight effects on biology
- Viral Infectious Diseases and Gene Expression in Insects
- Magnetic and Electromagnetic Effects
- Connective tissue disorders research
- Biomarkers in Disease Mechanisms
Imtek (Russia)
2015-2024
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2023-2024
Koltzov Institute of Developmental Biology
2021-2023
Gamalei Institute of Epidemiology and Microbiology
2014-2021
Ministry of Health of the Russian Federation
2014-2021
Russian Academy of Sciences
2014
Academy of Medical Sciences
2014
Magnetic levitational bioassembly of three-dimensional (3D) tissue constructs represents a rapidly emerging scaffold- and label-free approach alternative conceptual advance in engineering. The magnetic bioassembler has been designed, developed, certified for life space research. To the best our knowledge, 3D have biofabricated first time under microgravity from spheroids consisting human chondrocytes. Bioassembly sequential spheroid fusion presented good agreement with developed predictive...
During biofabrication, a tissue scaffold may require temporary support. The aim of this study was to develop an approach human thyroid cartilage temporal support formation. 3D-model based on DICOM images. XY plane projections were used form supporting part. To verify the technique, collagen hydrogel chosen as main component. Gelatin applied for test applicability approach, model with printed. corresponded given model, although some discrepancy in geometry observed during verification by...
The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for de novo cartilage formation. Extrusion-based bioprinting used biofabrication. printing parameters were tuned to obtain stable material flow. In vivo data proved ability tested form within five six weeks after subcutaneous scaffold implantation. Certain areas formation detected as early in one week. resulting tissue had distinctive structure with groups isogenic cells well high content...
In situ bioprinting is one of the most clinically relevant techniques in emerging technology because it could be performed directly on human body operating room and does not require bioreactors for post-printing tissue maturation. However, commercial bioprinters are still available market. this study, we demonstrated benefit originally developed first articulated collaborative bioprinter treatment full-thickness wounds rat porcine models. We used an robotic arm from company KUKA original...
The aim of this study was to verify the applicability high-concentration collagen-based bioink with MSC (ADSC) and decellularized ECM granules for formation cartilage tissue de novo after subcutaneous implantation scaffolds in rats. printability (4% collagen, 2.5% granules, derived via 280 μm sieve) shown. Three compositions were studied: (1) ECM; (2) MSC; (3) MSC. It has been established that are able stimulate chondrogenesis both cell-free MSC-laden scaffolds. Undesirable effects have...
With the development of regenerative medicine in ophthalmology, identification cells with high proliferative potential limbal area has attracted attention ophthalmologists and offered a new option for treatment clinical practice. Limbal stem cell deficiency (LSCD) is an identified eye disease difficult negative outcome, which traditional keratoplasty. This study sought to evaluate efficacy matrix-assisted transplantation consisting vitro-cultured autologous (LSCs) type I collagen LSCD...
Purpose: The aim of this study was to evaluate Viscoll collagen membrane (VCM) for lamellar keratoplasty. Methods: A 54-year-old man with grade 4 recurrent pterygium underwent keratoplasty using VCM as the graft material. Standard postoperative treatments, including topical antibiotic-corticosteroid and artificial tears, were administered. Results: Complete epithelialization achieved after days surgery. Follow-up at 9 months showed no recurrence well good integration into surrounding tissues...
In dentistry, maxillofacial surgery, traumatology, and orthopedics, there is a need to use osteoplastic materials that have not only osteoinductive osteoconductive properties but are also convenient for use. the study, compositions based on collagen hydrogel were developed. Polylactide granules (PLA) or traditional bone graft, mixture of hydroxyapatite β-tricalcium phosphate (HAP/β-TCP), used gel filling improve mechanical compositions. The tests showed hydrogels filled with 12 wt% highly...
Restoring the anatomical and functional characteristics of cornea using various biomaterials is especially relevant in context a global shortage donor tissue. Such must be biocompatible, strong, transparent. Here, we report Viscoll collagen membrane with mechanical optical properties suitable for replacing damaged stromal After removing portion stroma, was implanted into corneas rabbits. 6 months, active migration host cells membranes noted, preservation corneal transparency all experimental...
High-strength composite hydrogels based on collagen or chitosan–genipin were obtained via mixing using highly porous polylactide (PLA) microparticles with diameters of 50–75 µm and porosity values over 98%. The elastic modulus depended the filler concentration. increased from 80 kPa to 400–600 at a concentration particles 12–15 wt.% up 1.8 MPa filling 20–25 for hydrogels. hydrogel increases 75 900 fraction 20 wt.%. These cover range strength properties connective tissue cartilage tissue. It...
In the review, structure and biological properties of collagen, variants its production from natural sources purification are considered. Methods for modifying physico-mechanical collagen to create a curable, highly purified hydrogel described. The advantages cured as basis osteoplastic material means delivery growth factors indicated. registered materials based on curable described, their comparative analysis is carried out. On obtained data, conclusion was made about prospects using...