A5013692816- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Probiotics and Fermented Foods
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Ion-surface interactions and analysis
- Bacillus and Francisella bacterial research
- Antimicrobial Peptides and Activities
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Immune Response and Inflammation
- Biocrusts and Microbial Ecology
- Cystic Fibrosis Research Advances
- Microbial Metabolism and Applications
- Microbial Metabolites in Food Biotechnology
- Streptococcal Infections and Treatments
- Microbial Natural Products and Biosynthesis
- Mitochondrial Function and Pathology
- Biochemical and Structural Characterization
- Bacteriophages and microbial interactions
- Erythropoietin and Anemia Treatment
- Tracheal and airway disorders
- Neonatal and Maternal Infections
- Monoclonal and Polyclonal Antibodies Research
Gamalei Institute of Epidemiology and Microbiology
2017-2024
V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry
2017-2024
Russian Academy of Sciences
2004-2024
Ministry of Health of the Russian Federation
2017-2024
Institute of Bioorganic Chemistry
2003-2010
Northwestern University
2005
NS Kurnakova Institute of General and Inorganic Chemistry
2004
Lomonosov Moscow State University
2002
Significance Post-traumatic sterile inflammation is the first necessary step of wound healing. In addition, underlies pathogenesis a multitude common diseases, such as allergies and autoimmune diseases. The molecular mechanisms underlying are still not fully understood. Here, we show that receptor Mincle (Clec4e), expression which highly induced in skin response to damage, recognizes cholesterol sulfate, molecule abundant epidermal layer skin, subsequently inducing pro-inflammatory response....
The increasing prevalence of antibiotic-resistant strains pathogenic bacteria is a major healthcare problem. Antibacterial lysins are enzymes that cleave the peptidoglycan bacterial cell wall. These proteins hold potential as supplement or an alternative to traditional antibiotics since they active against antibiotic resistant strains. However, antibacterial rapidly eliminated from systemic circulation, which limits their application. Dimerization anti-pneumococcal lysin Cpl-1 has been...
Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers immunity. One the effective strategies improve vaccine efficacy incorporation adjuvant molecules that enhance polarize adaptive reactions. Effects Syk-coupled lectin receptor agonists as adjuvants induce reactions parenteral immunization not fully studied. We now report...
Staphylococcus aureus is a Gram-positive bacterium that causes severe illnesses in the human population. The capacity of S. strains to form biofilms on biotic and abiotic surfaces creates serious problems for treatment hospital infections has stimulated efforts develop new means specific protection or immunotherapy.We found rabbit serum raised against crude concentrated liquid culture significantly decreased development staphylococcal biofilm vitro. To discover corresponding antigen, we used...
Antibacterial lysins are promising proteins that active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial is their fast elimination from systemic circulation. PEGylation increases the plasma half-life but renders them inactive. Here we report construction fusion protein lysostaphin, potent anti-staphylococcal lysin, an albumin-binding domain streptococcal G. The resulting was less than parent enzyme it still retained...
The process of stone formation in the human body remains incompletely understood, which requires clinical and laboratory studies formulation a new endogenous, nanotechnological concept mechanism origin crystallization centers. Previously, sialolithiasis was considered congenital disease associated with pathology ducts structure glands themselves. To date, such morphological changes nature can be from position intrauterine endogenous bacterial infections complicated by migration antigenic...
MALDI-TOF MS represents a rapid and cost-effective method for identifying proteins microorganisms. When obtaining recombinant protein producers, differences in expression levels among transformants necessitate the conduction of small-scale screening levels. This study proposes fast easy clones producing using MS. Various proteins, expressed E. coli, were employed to test proposed method.
Primary ciliary dyskinesia (PCD) is a rare hereditary disease belonging to the group of ciliopathies. PCD caused by defect in ultrastructure cilia respiratory epithelium and similar structures (sperm flagella, fallopian tube villi, ventricular ependyma) with prevalence 1:10,000 1:30,000 people. One main problems associated this condition frequent recurrent bacterial infections, which lead decreased lung function development bronchiectasis. The aim was study microbial landscape tract patients...
The main cause of death in patients with cystic fibrosis (CF) is infectious process the lungs, particular, chronic lung infections caused by various pathogens, most often a combination bacteria, fungi, or viruses. Data on mixed bacterial and viral-bacterial from domestic foreign sources are fragmentary sparse. dominant associations viral pathogens have not been studied properly, data their epidemiological significance lacking. aim this study was to assess prevalence substantiate need for...