A5056056811- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Wheat and Barley Genetics and Pathology
- Phytase and its Applications
- Plant Gene Expression Analysis
- Neurogenesis and neuroplasticity mechanisms
- Prion Diseases and Protein Misfolding
- Neuroscience and Neuropharmacology Research
- Genetic Mapping and Diversity in Plants and Animals
- Plant Genetic and Mutation Studies
- Plant Molecular Biology Research
- Fermentation and Sensory Analysis
- Microbial Metabolism and Applications
- Phytochemicals and Antioxidant Activities
- Axon Guidance and Neuronal Signaling
- Optical Imaging and Spectroscopy Techniques
- Proteins in Food Systems
- Legume Nitrogen Fixing Symbiosis
- Plant tissue culture and regeneration
- Helicobacter pylori-related gastroenterology studies
- Biochemical effects in animals
- Gastrointestinal motility and disorders
- Fungal and yeast genetics research
- Glioma Diagnosis and Treatment
St Petersburg University
2014-2025
Julius Kühn-Institut
2021
Vavilov Institute of General Genetics
2021
Czech Academy of Sciences, Institute of Physiology
2003-2004
Significance Post-traumatic sterile inflammation is the first necessary step of wound healing. In addition, underlies pathogenesis a multitude common diseases, such as allergies and autoimmune diseases. The molecular mechanisms underlying are still not fully understood. Here, we show that receptor Mincle (Clec4e), expression which highly induced in skin response to damage, recognizes cholesterol sulfate, molecule abundant epidermal layer skin, subsequently inducing pro-inflammatory response....
Amyloids are protein aggregates with a highly ordered spatial structure giving them unique physicochemical properties. Different amyloids not only participate in the development of numerous incurable diseases but control vital functions archaea, bacteria and eukarya. Plants poorly studied systematic group field amyloid biology. Amyloid properties have yet been demonstrated for plant proteins under native conditions vivo. Here we show that seeds garden pea Pisum sativum L. contain...
The color of grain in cereals is determined mainly by anthocyanin pigments. A large level genetic diversity for content and composition the different species was observed. In rye, recessive mutations six genes (vi1...vi6) lead to absence anthocyanins all parts plant. Moreover, dominant synthesis aleurone (gene C) pericarp Vs) also affect grain. Reverse phase high-performance liquid chromatography mass spectrometry were used study 24 rye samples. lack lines with yellow brown determined....
The formation of self-perpetuating protein aggregates such as amyloids is associated with various diseases and provides a basis for transmissible (infectious or heritable) isoforms (prions). Many human proteins involved in the regulation transcription contain potentially amyloidogenic regions. Here, it shown that short N-terminal PHC3, component chromatin-modifying complex PRC1 (Polycomb repressive 1), can form prion-like yeast assays, exhibit amyloid properties E. coli-based C-DAG assay,...
Amyloids represent protein fibrils with a highly ordered spatial structure, which not only cause dozens of incurable human and animal diseases but also play vital biological roles in Archaea, Bacteria, Eukarya. Despite the fact that association bacterial amyloids microbial pathogenesis infectious is well known, there lack information concerning symbiotic bacteria. In this study, using previously developed proteomic method for screening identification (PSIA), we identified amyloidogenic...
Despite a long history of research cortical marginal zone (MZ) organization and development, number issues remain unresolved. One particular issue is the problem Cajal-Retzius cells (C‑R) identification. It currently based on morphology Reelin expression. The aim this to investigate MZ cytoarchitectonics Reelin-producing morphotypes in superior temporal, pre- postcentral cortex at GW24-26. We used (Reln) as marker for microtubule-associated protein 2 (MAP2) neurofilament heavy chain (N200)...
With the wide use of magnetic resonance imaging (MRI) in clinical practice, more attention is paid to corpus callosum hypoplasia children with various central nervous system diseases, including cerebral palsy. We compared areas segments on mid-sagittal MR images palsy and a control group; full-term infants preterm infants. During postnatal development, overall area naturally increases, but single change differently both absolute relative values. In group, splenium grew insignificantly,...
Flavonoids are a large group of secondary metabolites, which responsible for pigmentation, signaling, protection from unfavorable environmental conditions, and other important functions, as well providing numerous benefits human health. Various stages flavonoid biosynthesis subject to complex regulation by three groups transcription regulators – MYC-like bHLH, R2R3-MYB WDR form the MBW regulatory complex. We attempt cover main aspects this intriguing system in plants, summarize information...
BACKGROUND: Short stemness is an important trait for rye; most varieties of winter rye carry the dominant short gene Ddw1. A simple way to assess diversity chromosome region in which Ddw1 localized use REMS1218 microsatellite marker. AIM: The aim work study polymorphism marker six short-stemmed accessions from Peterhof genetic collection and plants Grafinya varietal population. MATERIALS AND METHODS: Six homozygous alleles several genes stemness/dwarfism a medium-tall population were...
In rye, there is a considerable variety of grain color which determined by the diversity compounds localized in different parts (caryopsis) - pericarp, testa, and aleurone. The localization anthocyanins proanthocyanidins was analyzed 26 rye samples with identified anthocyanin genes, along analysis CIE coordinates. Grain Scan program [1] used to analyze images individual grains. studied on longitudinal cross sections grains using light microscopy MALDI-imaging. violet-grained contain...
H. pylori infection changes the composition of gastric microbiota, but data in children are scared.Probiotics can improve results eradication therapy, as long adjuvant therapy.The aim our study to assess effectiveness monotherapy and therapy probiotic L. reuteri DSMZ17648 (Lr) (+) children. Material methods:In 103 patients 9 17 years, a double-blind, randomized, placebocontrolled was performed both (omeprazole + amoxicillin metronidazole bismuth-OAMB for 10days), Lr course subgroup A lasted...