A5057319470- Zebrafish Biomedical Research Applications
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Veterinary Orthopedics and Neurology
- Neurogenesis and neuroplasticity mechanisms
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Retinal Development and Disorders
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Muscle activation and electromyography studies
- Axon Guidance and Neuronal Signaling
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Neonatal and fetal brain pathology
- Cell Image Analysis Techniques
- Pain Management and Treatment
- Robotic Locomotion and Control
- Urinary Bladder and Prostate Research
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Motor Control and Adaptation
- Circadian rhythm and melatonin
- Advanced Scientific Research Methods
Pavlov Institute of Physiology of the Russian Academy of Sciences
2012-2025
University of Antwerp
2023
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Hudson Institute
2023
St Petersburg University
2016-2021
Russian Scientific Center of Radiology and Surgical Technologies
2018-2021
Ministry of Health of the Russian Federation
2018-2021
Yandex (Russia)
2019
Trace amine-associated receptors (TAARs) are a class of G protein-coupled found in mammals. While TAAR1 is expressed several brain regions, all the other TAARs have been described mainly olfactory epithelium and glomerular layer bulb believed to serve as new sensing innate odors. However, there evidence that TAAR5 could play role also central nervous system. In this study, we characterized mouse line lacking (TAAR5 knockout, TAAR5-KO) expressing beta-galactosidase mapping expression. We not...
Trace amines are a group of biogenic that structurally and functionally close to classical monoamine neurotransmitters. amine-associated receptors (TAARs) emerging as promising targets for treating neuropsychiatric disorders. It has been documented all TAARs, apart from TAAR1, function olfactory involved in sensing innate odors encoded by volatile amines. However, recently, brain expression TAAR5 were also demonstrated. In this study, we assessed the behavior, neurochemistry,...
ABSTRACT The “oblique effect” refers to the reduced visual performance for stimuli presented at oblique orientations compared those cardinal orientations. In cortex, neurons that respond specific are organized into orientation columns. This raises question: Are signals in iso‐orientation columns associated with same as orientations, and is this signal influenced by experience? To explore this, area 18 were examined using optical imaging techniques. Kittens raised under either standard or...
Higher vertebrates, including humans, are capable not only of forward (FW) locomotion but also walking in other directions relative to the body axis [backward (BW), sideways, etc.]. Although neural mechanisms responsible for controlling FW have been studied considerable detail, steps mostly unknown. The aim present study was investigate distribution spinal neuronal networks and BW locomotion. First, we applied electrical epidural stimulation (ES) different segments cord from L2 S2 reveal...
ABSTRACT Detailed knowledge of the topographic organization and precise access to spinal cord segments is crucial for neurosurgical manipulations as well in vivo neurophysiological investigations networks involved sensorimotor visceral functions. Because high individual variability, accurate identification particular portion lumbosacral enlargement normally possible only during postmortem dissection. Yet, it often necessary determine location prior investigation, targeting manipulations,...
The distribution of vitamin D-dependent calcium-binding protein (28 kDa calbindin) was investigated in cat lumbar and sacral spinal cord segments (L1-S3). We observed specific multi-dimensional distributions over the for small immunopositive cells Rexed laminae II-III medium-to-large varying morphology lamina I V-VIII. neurons were clustered into columns along dorsal horn curvature. grouped four assemblages that located (1) most lateral region VII at L1-L4 level, (2) IV-V boundary L5-L7 (3)...
The spinal cord is a complex heterogeneous structure, which provides multiple vital functions. precise surgical access to the regions of interest requires schemes for structure and spatial relation between vertebrae. One way obtain such information combined anatomical morphological atlas. widely used models investigation functions cat. We create single cell-resolution atlas cat using variety neurochemical markers [antibodies NeuN, choline acetyltransferase, calbindin 28 kDa, calretinin,...
Key points Epidural electrical stimulation (ES) of the spinal cord restores/improves locomotion in patients. ES‐evoked locomotor movements differ to some extent from normal ones. Operation network during ES is unknown. We compared activity individual neurons initiated by signals brainstem and ES. demonstrated that generating under each two conditions formed same neurons. A part this operates similarly conditions, suggesting it essential for generation both conditions. Another differently...
Abstract Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role trace amines and their receptors in function remains unexplored. Using amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localization, we observed TAAR5 expression Purkinje cells cerebellum medial vestibular nucleus, suggesting might be involved motor control. Accordingly, various behavioral tests, TAAR5-KO mice demonstrated lower...
Impairments of the lower urinary tract function including urine storage and voiding are widely spread among patients with spinal cord injuries. The management such includes bladder catheterization, surgical pharmacological approaches, which reduce morbidity from tract-related complications. However, to date, there is no effective treatment neurogenic restoration function. In present study, we examined neuromodulation detrusor (Detr) external urethral sphincter by epidural electrical...
Abstract We show that epidural spinal cord stimulation can elicit stable bidirectional locomotion of decerebrate cats on a split-belt treadmill. The stepping pattern one limb was similar to unidirectional forward walking and, the other—was backward walking. This confirms and brainstem circuitry are sufficient control such complex extraordinary motor tasks driven by somatosensory input. Interlimb coordination during preserved in 2 out 4 animals ‘extreme’ conditions when treadmill belts...
Acomys cahirinus is a unique Rodentia species with several distinctive physiological traits, such as precocial development and remarkable regenerative abilities. These characteristics render A. increasingly valuable for developmental physiology studies. Despite this, the structure postnatal of central nervous system in have been inadequately explored, only sporadic data available. This study first series papers addressing these gaps. Our objective was to characterize main visual thalamic...
Acomys cahirinus is a unique Rodentia species with several distinctive physiological traits, such as precocial development and remarkable regenerative abilities. These characteristics render A. increasingly valuable for developmental physiology studies. Despite this, the structure postnatal of central nervous system in have been inadequately explored, only sporadic data available. This study first series papers addressing these gaps. Our objective was to characterize main visual thalamic...
Accumulation of the heavy-chain neurofilaments reflects maturation status neuronal structures. The spatial distribution and postnatal developmental dynamic neurons expressing nonphosphorylated (labeled by SMI-32 antibody) were analyzed in dorsal lateral geniculate nucleus (LGNd) cat. Both interlaminar intralaminar differences staining observed. following results obtained: (a) Ascending dorsoventral gradient density immunopositive (SMI-32(+)) (the greatest layer Cm, minor top sublayer A)....
Abstract The thalamic reticular nucleus receives axons from the sensory nuclei and cerebral cortex. visual part of this in carnivores is perigeniculate located dorsal to lateral geniculate nucleus. participates modulation processing transition synchronized slow rhythmicity during sleep into desynchronized high‐frequency activity arousal consists inhibitory neurons. main neurochemical markers for neurons are glutamic acid decarboxylase Ca 2+ ‐binding protein parvalbumin. Previous studies...
A biophysically detailed description of the mechanisms primary vision is still being developed. We have incorporated a simplified, filter-based retino-thalamic visual signal processing into detailed, conductance-based refractory density neuronal population activity cortex. compared four direction selectivity (DS), three them based on asymmetrical projections different types thalamic neurons to cortex, distinguishing between (i) lagged and nonlagged, (ii) transient sustained, (iii) On Off...